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- W2000490629 abstract "Abstract Chloroquine-induced respiratory depression was studied in anaesthetized dogs and non-anaesthetized decerebrate cats. The pattern of respiration was gradually converted to preapneustic, apneustic, ataxic and finally gasping forms terminating with respiratory arrest. The systemic blood pressure remained steady and only fell during the last two phases. It was inferred that chloroquine depresses respiration in a ponto-medullary direction, thus the more rostral multisynaptic pathways are affected before the oligosynaptic links. It appears that this neuronal depression results from the local anaesthetic properties of chloroquine." @default.
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- W2000490629 date "1973-04-01" @default.
- W2000490629 modified "2023-09-24" @default.
- W2000490629 title "Specific influence of chloroquine on central respiratory mechanisms" @default.
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- W2000490629 doi "https://doi.org/10.1016/0014-2999(73)90187-8" @default.
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