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- W2000491756 abstract "We studied the vasodilatory effects of fentanyl, remifentanil and sufentanil on the human saphenous vein strips at 37, 32 and 28 °C. Fentanyl produced concentration-dependent relaxation of human saphenous vein strips precontracted with 5-hydroxytryptamine (5-HT) at every temperature studied. Compared with vein strips at 37 °C, relaxant responses to each one concentration of fentanyl were significantly reduced at 32 and 28 °C. Remifentanil relaxed vein strips in a concentration-dependent way and the relaxation for all concentrations were significantly greater at 32 and 28 °C compared with 37 °C. Sufentanil produced concentration-dependent relaxation in saphenous vein strips precontracted with 5-HT. These relaxant responses were similar at 32 °C compared with 37 °C. When bath temperature was lowered from 37 to 28 °C, the relaxant responses to sufentanil were significantly reduced. In summary, the present study suggests that cooling reduces the relaxation caused by fentanyl and sufentanil on human saphenous veins but augments the relaxation with remifentanil. The augmented vasodilatory effect of remifentanil with cooling may be useful on systemic vascular resistance and organ preservation under hypothermic conditions like cardiopulmonary bypass surgery." @default.
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- W2000491756 date "2006-10-01" @default.
- W2000491756 modified "2023-09-27" @default.
- W2000491756 title "Effect of cooling on the responses of human saphenous vein to fentanyl, remifentanil and sufentanil" @default.
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- W2000491756 doi "https://doi.org/10.1111/j.1472-8206.2006.00434.x" @default.
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