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• W2000492065 abstract "Ionic conditions were varied during homogenization of adult liv- ers and during incubation of hepatic cytosol with glucocorticoid, and the effects on the detection of differences between inbred strains of mice for receptor levels were studied. When homogenized directly in 0.01 M Tris or homogenized in dis- tilled water and then buffered to either 0.05 M Tris or 0.01 M potassium phos- phate, A/J glucocorticoid receptor levels were greater than those of BIO.A. How- ever, when homogenized directly in 0.05 M Tris or buffered to 0.05 M potassium phosphate after homogenization in distilled water, A/J and BIO.A had similar receptor levels. When buffered to 0.01 M Tris after homogenization in distilled water, A/J receptor levels were greater than those of BIO.A but not significantly so. In Tris buffers, glucocorticoid receptor levels were higher when livers were homogenized directly in buffer than when liver homogenates were buffered after homogenization. This concentration effect is apparently due to the more rapid decay of glucocorticoid receptor in the lower molarity buffer. A reducing agent, thioglycerol, did not appear to affect either the rate of decay of the receptors or the measured level of receptor for BIO.A and A/J. C57BL/6J receptor levels were measured in Tris buffers and had a similar relationship to A/J as did BIO.A. A popular model for studies of cleft palate is glucocorticoid-induced cleft palate in mice (Fraser and Fainstat, '51). Inbred strains of mice differ significantly for susceptibility to glucocorticoid-induced cleft palate, and it has been suggested that genetic variation in amount of glucocorticoid receptor may be a part of the explanation for this variation. However, there has been considerable controversy about the direction and degree of difference among inbred mouse strains for amount of glucocorticoid re- ceptor. Salomon and Pratt presented evidence that cultured, embryonic facial mesenchyme cells from a strain with high susceptibility to glucocorticoid-induced cleft palate, A/J, have about twice as many specific steroid receptors as do such cells from a low susceptibility strain, C57BU6 (Salomon and Pratt, '76). They also found a correlation of sensitivity to steroid- induced cleft palate with amount of steroid- specific receptor in cultured facial mesen- chyme cells among several inbred strains of mice (Salomon and Pratt, '79). Goldman et al. ('77) provided data that this variation in the amount of steroid receptor was associated with H-2 genotype, but this conclusion was con- tested. We demonstrated that a difference be-" @default.
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• W2000492065 date "1983-02-01" @default.
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• W2000492065 title "Ionic effects on strain differences in hepatic cytosolic glucocorticoid receptor levels in mice" @default.
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• W2000492065 doi "https://doi.org/10.1002/tera.1420270107" @default.
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