FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000492706> ?p ?o ?g. }

• W2000492706 endingPage "206" @default.
• W2000492706 startingPage "196" @default.
• W2000492706 abstract "The pathophysiology of gait and balance disorders in elderly people with 'higher level gait disorders' (HLGD) is poorly understood. In this study, we aimed to identify the brain networks involved in this disorder. Standardised clinical scores, biomechanical parameters of gait initiation and brain imaging data, including deep white matter lesions (DWML) and brain voxel-based morphometry analyses, were assessed in 20 HLGD patients in comparison to 20 age-matched controls. In comparison to controls, HLGD patients presented a near-normal preparatory phase of gait initiation, but a severe alteration of both locomotor and postural parameters of first-step execution, which was related to 'axial' hypokinetic-rigid signs. HLGD patients showed a significant grey matter reduction in the mesencephalic locomotor region (MLR) and the left primary motor cortex. This midbrain atrophy was related to the severity of clinical and neurophysiologically determined balance deficits. HLGD patients also showed a reduction in speed of gait, related to 'appendicular' hypokinetic-rigid signs and frontal-lobe-like cognitive deficits. These last two symptoms were correlated with the severity of DWML, found in 12/20 HLGD patients. In conclusion, these data suggest that the gait and balance deficits in HLGD mainly result from the lesion or dysfunction of the network linking the primary motor cortex and the MLR, brain regions known to be involved in the control of gait and balance, whereas cognitive and 'appendicular' hypokinetic-rigid signs mainly result from DWML that could be responsible for a dysfunction of the frontal cortico-basal ganglia loops." @default.
• W2000492706 created "2016-06-24" @default.
• W2000492706 creator A5011216618 @default.
• W2000492706 creator A5014732002 @default.
• W2000492706 creator A5023246764 @default.
• W2000492706 creator A5031611475 @default.
• W2000492706 creator A5033034157 @default.
• W2000492706 creator A5036373723 @default.
• W2000492706 creator A5042358690 @default.
• W2000492706 creator A5049855793 @default.
• W2000492706 creator A5055606592 @default.
• W2000492706 creator A5060150839 @default.
• W2000492706 creator A5065401900 @default.
• W2000492706 creator A5013966194 @default.
• W2000492706 date "2013-11-08" @default.
• W2000492706 modified "2023-10-08" @default.
• W2000492706 title "High-level gait and balance disorders in the elderly: a midbrain disease?" @default.
• W2000492706 cites W1487126167 @default.
• W2000492706 cites W1971033359 @default.
• W2000492706 cites W1979487414 @default.
• W2000492706 cites W1985225119 @default.
• W2000492706 cites W1987390005 @default.
• W2000492706 cites W1987528617 @default.
• W2000492706 cites W1991751738 @default.
• W2000492706 cites W1991915240 @default.
• W2000492706 cites W1998545016 @default.
• W2000492706 cites W2004344916 @default.
• W2000492706 cites W2005594265 @default.
• W2000492706 cites W2008445652 @default.
• W2000492706 cites W2008813344 @default.
• W2000492706 cites W2010285555 @default.
• W2000492706 cites W2012994259 @default.
• W2000492706 cites W2014345907 @default.
• W2000492706 cites W2017146961 @default.
• W2000492706 cites W2024835440 @default.
• W2000492706 cites W2036978525 @default.
• W2000492706 cites W2038087459 @default.
• W2000492706 cites W2038805077 @default.
• W2000492706 cites W2041065825 @default.
• W2000492706 cites W2044951073 @default.
• W2000492706 cites W2052762187 @default.
• W2000492706 cites W2058339527 @default.
• W2000492706 cites W2063610808 @default.
• W2000492706 cites W2065363897 @default.
• W2000492706 cites W2067071952 @default.
• W2000492706 cites W2073406198 @default.
• W2000492706 cites W2080205373 @default.
• W2000492706 cites W2084664771 @default.
• W2000492706 cites W2087575813 @default.
• W2000492706 cites W2089141705 @default.
• W2000492706 cites W2095807272 @default.
• W2000492706 cites W2096549249 @default.
• W2000492706 cites W2101044573 @default.
• W2000492706 cites W2106108170 @default.
• W2000492706 cites W2111402708 @default.
• W2000492706 cites W2113034373 @default.
• W2000492706 cites W2123954634 @default.
• W2000492706 cites W2129935451 @default.
• W2000492706 cites W2131760028 @default.
• W2000492706 cites W2136276906 @default.
• W2000492706 cites W2136451283 @default.
• W2000492706 cites W2137310042 @default.
• W2000492706 cites W2139695342 @default.
• W2000492706 cites W2144411504 @default.
• W2000492706 cites W2148903189 @default.
• W2000492706 cites W2150178032 @default.
• W2000492706 cites W2153567575 @default.
• W2000492706 cites W2162798142 @default.
• W2000492706 cites W2164025570 @default.
• W2000492706 cites W2169366712 @default.
• W2000492706 cites W4246513388 @default.
• W2000492706 doi "https://doi.org/10.1007/s00415-013-7174-x" @default.
• W2000492706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3895186" @default.
• W2000492706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24202784" @default.
• W2000492706 hasPublicationYear "2013" @default.
• W2000492706 type Work @default.
• W2000492706 sameAs 2000492706 @default.
• W2000492706 citedByCount "36" @default.
• W2000492706 countsByYear W20004927062014 @default.
• W2000492706 countsByYear W20004927062015 @default.
• W2000492706 countsByYear W20004927062016 @default.
• W2000492706 countsByYear W20004927062017 @default.
• W2000492706 countsByYear W20004927062018 @default.
• W2000492706 countsByYear W20004927062019 @default.
• W2000492706 countsByYear W20004927062020 @default.
• W2000492706 countsByYear W20004927062021 @default.
• W2000492706 countsByYear W20004927062022 @default.
• W2000492706 countsByYear W20004927062023 @default.
• W2000492706 crossrefType "journal-article" @default.
• W2000492706 hasAuthorship W2000492706A5011216618 @default.
• W2000492706 hasAuthorship W2000492706A5013966194 @default.
• W2000492706 hasAuthorship W2000492706A5014732002 @default.
• W2000492706 hasAuthorship W2000492706A5023246764 @default.
• W2000492706 hasAuthorship W2000492706A5031611475 @default.
• W2000492706 hasAuthorship W2000492706A5033034157 @default.
• W2000492706 hasAuthorship W2000492706A5036373723 @default.
• W2000492706 hasAuthorship W2000492706A5042358690 @default.
• W2000492706 hasAuthorship W2000492706A5049855793 @default.

• next