FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000492759> ?p ?o ?g. }

• W2000492759 endingPage "e30542" @default.
• W2000492759 startingPage "e30542" @default.
• W2000492759 abstract "Long-term hematopoietic stem cells (LT-HSCs) migrate from the fetal liver (FL) to the fetal bone marrow (FBM) during development. Various adhesion and chemotactic receptor genes have been implicated in the migration of adult LT-HSCs. However, their role in the migration of fetal LT-HSCs is not clearly understood due, in part, to the rare number of these cells in fetal tissues, which preclude classical gene expression analysis. The aim of this study is to characterize the expression of migration related genes in fetal LT-HSC across different anatomical locations during development.We isolated fetal LT-HSC from different developmental stages, as well as different anatomical locations, and performed single-cell multiplex RT-qPCR and flow cytometry analysis of eight molecules involved in adult LT-HSC migration. Our results show that the gene expression of the chemokine receptor Cxcr4 in LT-HSC varies across developmental microenvironments and times, while the cadherin Cdh2 (Ncad) and the calcium receptor Casr show higher gene expression and variability only in FBM at 17.5 days post coitum (dpc). The cadherin Cdh5 (Vecad) maintains high expression variability only during fetal development, while the integrin subunit Itga5 (α5) increases its variability after 14.5 dpc. The integrin subunits Itga4 (α4) and Itgal (Lfa1), as well as the selectin ligand Selplg (Psgl1), did not show differences in their expression in single LT-HSCs irrespective of the developmental times or anatomical microenvironments studied.Our data demonstrate that the expression pattern of phenotypically identical, single LT-HSCs fluctuates as a function of developmental stage and anatomical microenvironment. This is the first exhaustive gene expression comparison of migration-related molecules in fetal tissues across developmental times, enhancing the understanding of LT-HSC migration fate decisions during development." @default.
• W2000492759 created "2016-06-24" @default.
• W2000492759 creator A5005682802 @default.
• W2000492759 creator A5006042983 @default.
• W2000492759 creator A5042111461 @default.
• W2000492759 creator A5043463869 @default.
• W2000492759 creator A5058028007 @default.
• W2000492759 creator A5081849853 @default.
• W2000492759 date "2012-01-20" @default.
• W2000492759 modified "2023-10-11" @default.
• W2000492759 title "Single-Cell Analysis of Murine Long-Term Hematopoietic Stem Cells Reveals Distinct Patterns of Gene Expression during Fetal Migration" @default.
• W2000492759 cites W1966817158 @default.
• W2000492759 cites W1969008892 @default.
• W2000492759 cites W1969073074 @default.
• W2000492759 cites W1975025595 @default.
• W2000492759 cites W1975247371 @default.
• W2000492759 cites W1987327612 @default.
• W2000492759 cites W1993375602 @default.
• W2000492759 cites W2003371248 @default.
• W2000492759 cites W2010612837 @default.
• W2000492759 cites W2011174877 @default.
• W2000492759 cites W2012326387 @default.
• W2000492759 cites W2014680491 @default.
• W2000492759 cites W2017063794 @default.
• W2000492759 cites W2021889129 @default.
• W2000492759 cites W2022644301 @default.
• W2000492759 cites W20228888 @default.
• W2000492759 cites W2025950643 @default.
• W2000492759 cites W2027610354 @default.
• W2000492759 cites W2032494769 @default.
• W2000492759 cites W2033488512 @default.
• W2000492759 cites W2038282968 @default.
• W2000492759 cites W2040664117 @default.
• W2000492759 cites W2041590882 @default.
• W2000492759 cites W2051857023 @default.
• W2000492759 cites W2054322335 @default.
• W2000492759 cites W2076188533 @default.
• W2000492759 cites W2077330278 @default.
• W2000492759 cites W2081408582 @default.
• W2000492759 cites W2081769332 @default.
• W2000492759 cites W2083612980 @default.
• W2000492759 cites W2084156847 @default.
• W2000492759 cites W2085188150 @default.
• W2000492759 cites W2090890518 @default.
• W2000492759 cites W2093818708 @default.
• W2000492759 cites W2095535774 @default.
• W2000492759 cites W2100890363 @default.
• W2000492759 cites W2103740237 @default.
• W2000492759 cites W2108533273 @default.
• W2000492759 cites W2108778569 @default.
• W2000492759 cites W2114342114 @default.
• W2000492759 cites W2118025269 @default.
• W2000492759 cites W2128238959 @default.
• W2000492759 cites W2128964206 @default.
• W2000492759 cites W2135153411 @default.
• W2000492759 cites W2141593635 @default.
• W2000492759 cites W2141688036 @default.
• W2000492759 cites W2143903091 @default.
• W2000492759 cites W2145452684 @default.
• W2000492759 cites W2148463169 @default.
• W2000492759 cites W2167763418 @default.
• W2000492759 cites W2405572490 @default.
• W2000492759 cites W2747900948 @default.
• W2000492759 doi "https://doi.org/10.1371/journal.pone.0030542" @default.
• W2000492759 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3262840" @default.
• W2000492759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22276210" @default.
• W2000492759 hasPublicationYear "2012" @default.
• W2000492759 type Work @default.
• W2000492759 sameAs 2000492759 @default.
• W2000492759 citedByCount "14" @default.
• W2000492759 countsByYear W20004927592012 @default.
• W2000492759 countsByYear W20004927592013 @default.
• W2000492759 countsByYear W20004927592014 @default.
• W2000492759 countsByYear W20004927592015 @default.
• W2000492759 countsByYear W20004927592016 @default.
• W2000492759 countsByYear W20004927592017 @default.
• W2000492759 countsByYear W20004927592018 @default.
• W2000492759 countsByYear W20004927592019 @default.
• W2000492759 countsByYear W20004927592020 @default.
• W2000492759 countsByYear W20004927592023 @default.
• W2000492759 crossrefType "journal-article" @default.
• W2000492759 hasAuthorship W2000492759A5005682802 @default.
• W2000492759 hasAuthorship W2000492759A5006042983 @default.
• W2000492759 hasAuthorship W2000492759A5042111461 @default.
• W2000492759 hasAuthorship W2000492759A5043463869 @default.
• W2000492759 hasAuthorship W2000492759A5058028007 @default.
• W2000492759 hasAuthorship W2000492759A5081849853 @default.
• W2000492759 hasBestOaLocation W20004927591 @default.
• W2000492759 hasConcept C104317684 @default.
• W2000492759 hasConcept C109159458 @default.
• W2000492759 hasConcept C150194340 @default.
• W2000492759 hasConcept C153911025 @default.
• W2000492759 hasConcept C172680121 @default.
• W2000492759 hasConcept C2779234561 @default.
• W2000492759 hasConcept C28328180 @default.
• W2000492759 hasConcept C54355233 @default.
• W2000492759 hasConcept C86803240 @default.
• W2000492759 hasConcept C95444343 @default.

• next