Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000493004> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2000493004 endingPage "1462" @default.
- W2000493004 startingPage "1458" @default.
- W2000493004 abstract "Reductions in circulating estradiol concentrations could be implicated in the pathogenesis of steroid-induced osteoporosis (SIOP) in men. We assessed serum estradiol and adrenal androgens (dehydroepiandrosterone sulfate [DHEAS] and androstenedione) in 77 men (group A: idiopathic osteoporosis [IOP], n = 38, aged [mean +/- SD] 57.7 +/- 12.1 years; group B: SIOP, n = 39, aged 55.3 +/- 13.1 years). We also studied the relationship between bone mineral density (BMD) and serum estradiol in the group of men with SIOP. In group B, we observed a higher prevalence of low serum testosterone concentrations (<9.0 nmol/L) (P =.0052), which was significantly correlated with steroid dosage (r = -0.42, P =.0089) and estradiol concentrations (r = 0.42, P =.012). There was a significant positive association between BMD at the lumbar spine and serum estradiol (P =.004) in the men with SIOP (group B). A high proportion of subjects had low serum estradiol concentrations (<48 pmol/L) in both groups (group A: 44.7 %, group B: 36 %). Serum adrenal androgens concentrations were also significantly suppressed in group B (serum androstenedione-group A: 4.99 +/- 1.8; Group B: 2.1 +/- 1.6 nmol/L; P =.0001). Serum DHEAS was undetectable in 59% of patients in group B versus 6% in group A (P =.001). Reductions in androstenedione also correlated with steroid dosage (r = -0.35, P =.01). In conclusion, the data show that adrenal androgens synthesis is markedly suppressed in men with SIOP. The clinical relevance of this finding remains to be determined. This study also shows a positive association between serum estradiol and BMD and a high prevalence of low serum estradiol in men with SIOP. Low serum estradiol may contribute to bone loss in men with SIOP." @default.
- W2000493004 created "2016-06-24" @default.
- W2000493004 creator A5000434069 @default.
- W2000493004 creator A5000844351 @default.
- W2000493004 creator A5015520850 @default.
- W2000493004 creator A5032448943 @default.
- W2000493004 creator A5039625365 @default.
- W2000493004 creator A5058187350 @default.
- W2000493004 date "2002-11-01" @default.
- W2000493004 modified "2023-09-27" @default.
- W2000493004 title "Low circulating estradiol and adrenal androgens concentrations in men on glucocorticoids: A potential contributory factor in steroid-induced osteoporosis" @default.
- W2000493004 cites W1541013001 @default.
- W2000493004 cites W1965370016 @default.
- W2000493004 cites W1970025509 @default.
- W2000493004 cites W1973591042 @default.
- W2000493004 cites W1999997178 @default.
- W2000493004 cites W2066371380 @default.
- W2000493004 cites W2098094256 @default.
- W2000493004 cites W2116271944 @default.
- W2000493004 cites W2120122580 @default.
- W2000493004 cites W2137112407 @default.
- W2000493004 cites W2146408916 @default.
- W2000493004 cites W2155622922 @default.
- W2000493004 cites W2157813808 @default.
- W2000493004 cites W2289440745 @default.
- W2000493004 cites W2329973775 @default.
- W2000493004 doi "https://doi.org/10.1053/meta.2002.35583" @default.
- W2000493004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12404198" @default.
- W2000493004 hasPublicationYear "2002" @default.
- W2000493004 type Work @default.
- W2000493004 sameAs 2000493004 @default.
- W2000493004 citedByCount "23" @default.
- W2000493004 countsByYear W20004930042014 @default.
- W2000493004 countsByYear W20004930042017 @default.
- W2000493004 countsByYear W20004930042018 @default.
- W2000493004 countsByYear W20004930042021 @default.
- W2000493004 crossrefType "journal-article" @default.
- W2000493004 hasAuthorship W2000493004A5000434069 @default.
- W2000493004 hasAuthorship W2000493004A5000844351 @default.
- W2000493004 hasAuthorship W2000493004A5015520850 @default.
- W2000493004 hasAuthorship W2000493004A5032448943 @default.
- W2000493004 hasAuthorship W2000493004A5039625365 @default.
- W2000493004 hasAuthorship W2000493004A5058187350 @default.
- W2000493004 hasConcept C126322002 @default.
- W2000493004 hasConcept C134018914 @default.
- W2000493004 hasConcept C2776541429 @default.
- W2000493004 hasConcept C2776683971 @default.
- W2000493004 hasConcept C2776886416 @default.
- W2000493004 hasConcept C2776992908 @default.
- W2000493004 hasConcept C2777785397 @default.
- W2000493004 hasConcept C2777911890 @default.
- W2000493004 hasConcept C2779279991 @default.
- W2000493004 hasConcept C2780657110 @default.
- W2000493004 hasConcept C71315377 @default.
- W2000493004 hasConcept C71924100 @default.
- W2000493004 hasConceptScore W2000493004C126322002 @default.
- W2000493004 hasConceptScore W2000493004C134018914 @default.
- W2000493004 hasConceptScore W2000493004C2776541429 @default.
- W2000493004 hasConceptScore W2000493004C2776683971 @default.
- W2000493004 hasConceptScore W2000493004C2776886416 @default.
- W2000493004 hasConceptScore W2000493004C2776992908 @default.
- W2000493004 hasConceptScore W2000493004C2777785397 @default.
- W2000493004 hasConceptScore W2000493004C2777911890 @default.
- W2000493004 hasConceptScore W2000493004C2779279991 @default.
- W2000493004 hasConceptScore W2000493004C2780657110 @default.
- W2000493004 hasConceptScore W2000493004C71315377 @default.
- W2000493004 hasConceptScore W2000493004C71924100 @default.
- W2000493004 hasIssue "11" @default.
- W2000493004 hasLocation W20004930041 @default.
- W2000493004 hasLocation W20004930042 @default.
- W2000493004 hasOpenAccess W2000493004 @default.
- W2000493004 hasPrimaryLocation W20004930041 @default.
- W2000493004 hasRelatedWork W1976801771 @default.
- W2000493004 hasRelatedWork W1979102595 @default.
- W2000493004 hasRelatedWork W2005723451 @default.
- W2000493004 hasRelatedWork W2056500036 @default.
- W2000493004 hasRelatedWork W2067172377 @default.
- W2000493004 hasRelatedWork W2067765841 @default.
- W2000493004 hasRelatedWork W2074423099 @default.
- W2000493004 hasRelatedWork W2116973468 @default.
- W2000493004 hasRelatedWork W2130662388 @default.
- W2000493004 hasRelatedWork W2144746424 @default.
- W2000493004 hasVolume "51" @default.
- W2000493004 isParatext "false" @default.
- W2000493004 isRetracted "false" @default.
- W2000493004 magId "2000493004" @default.
- W2000493004 workType "article" @default.