FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000493820> ?p ?o ?g. }

• W2000493820 endingPage "881." @default.
• W2000493820 startingPage "873" @default.
• W2000493820 abstract "Background Alpha(2)-Adrenergic agonists such as clonidine and dexmedetomidine are known to produce sedation and analgesia in humans. The sedative effect of these agents is thought to occur through supraspinal pathways, involving the locus ceruleus (LC) and its projections in rats. While the antinociceptive response to alpha(2) agonists, given intrathecally, is mediated predominantly in the spinal cord, other sites of action have not been systematically studied. The authors examined whether alpha(2)-adrenergic receptors in the LC mediate an antinociceptive effect. Methods For administration of different drugs into the LC, guide cannulas were placed with their tips in the LC in male Sprague-Dawley rats. Dexmedetomidine (3.5 micrograms/0.2 microliter) was microinjected into the LC through the cannula, or given systemically by intraperitoneal injecton (50 micrograms/kg). The antinociceptive effect of dexmedetomidine was measured using the tail-flick latency response. To determine the sites through which dexmedetomidine injection into the LC produces antinociception, the authors examined whether this response could be perturbed by the specific alpha(2)-adrenergic antagonists atipamezole and L659,066 and pertussis toxin administered either into the LC or intrathecally before injection of dexmedetomidine systemically or directly into the LC. To eliminate the possibility that drug administered in one site (LC or intrathecal) could reach the other site, the dispositional characteristics of radiolabeled dexmedetomidine (LC) or atipamezole (intrathecal) were studied. Results Dexmedetomidine placed into the LC produces a dose-dependent increase in the tail-flick latency. This antinociceptive effect was blocked by pertussis toxin and by the alpha(2) antagonists atipamezole and L659,066 placed in the LC. Intrathecal administration of atipamezole and pertussis toxin also blocked the antinociceptive effect of dexmedetomidine placed in the LC. (3)H-dexmedetomidine introduced into the LC did not reach the spinal cord in pharmacologically active concentrations; also, intrathecally administered (3)H-atipamezole did not reach the LC in appreciable amounts. The systemic administration of dexmedetomidine produced an increase in tail-flick latency, and this effect was attenuated by the injection of atipamezole and L659,066 into the LC. Conclusions Part of the mechanism by which dexmedetomidine produces an antinociceptive effect is by an action directly on the LC, demonstrated by these studies in which antinociception produced by injection of this drug into the LC can be blocked by specific alpha(2) antagonists injected into the LC. Furthermore, the action of dexmedetomidine in the LC in turn may result in an increase in activation of alpha(2) adrenoceptors in the spinal cord, because the antinociceptive effect of LC dexmedetomidine injection also can be blocked by intrathecal injection of antipamezole and pertussis toxin." @default.
• W2000493820 created "2016-06-24" @default.
• W2000493820 creator A5048023375 @default.
• W2000493820 creator A5065301160 @default.
• W2000493820 creator A5071434327 @default.
• W2000493820 creator A5087060170 @default.
• W2000493820 date "1996-04-01" @default.
• W2000493820 modified "2023-10-12" @default.
• W2000493820 title "Dexmedetomidine Injection into the Locus Ceruleus Produces Antinociception" @default.
• W2000493820 cites W140592118 @default.
• W2000493820 cites W1908535950 @default.
• W2000493820 cites W1973278698 @default.
• W2000493820 cites W1982324672 @default.
• W2000493820 cites W1985525186 @default.
• W2000493820 cites W1985655670 @default.
• W2000493820 cites W1992744164 @default.
• W2000493820 cites W1997114005 @default.
• W2000493820 cites W1997386700 @default.
• W2000493820 cites W2006741513 @default.
• W2000493820 cites W2008243901 @default.
• W2000493820 cites W2009737351 @default.
• W2000493820 cites W2010306385 @default.
• W2000493820 cites W2012040575 @default.
• W2000493820 cites W2016041892 @default.
• W2000493820 cites W2020184342 @default.
• W2000493820 cites W2023021788 @default.
• W2000493820 cites W2030573522 @default.
• W2000493820 cites W2040163165 @default.
• W2000493820 cites W2048248550 @default.
• W2000493820 cites W2056219178 @default.
• W2000493820 cites W2057614733 @default.
• W2000493820 cites W2063940371 @default.
• W2000493820 cites W2072344109 @default.
• W2000493820 cites W2112973554 @default.
• W2000493820 cites W2159687989 @default.
• W2000493820 cites W2163815564 @default.
• W2000493820 cites W2206143643 @default.
• W2000493820 cites W2207454985 @default.
• W2000493820 cites W2468424440 @default.
• W2000493820 doi "https://doi.org/10.1097/00000542-199604000-00015" @default.
• W2000493820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8638842" @default.
• W2000493820 hasPublicationYear "1996" @default.
• W2000493820 type Work @default.
• W2000493820 sameAs 2000493820 @default.
• W2000493820 citedByCount "290" @default.
• W2000493820 countsByYear W20004938202012 @default.
• W2000493820 countsByYear W20004938202013 @default.
• W2000493820 countsByYear W20004938202014 @default.
• W2000493820 countsByYear W20004938202015 @default.
• W2000493820 countsByYear W20004938202016 @default.
• W2000493820 countsByYear W20004938202017 @default.
• W2000493820 countsByYear W20004938202018 @default.
• W2000493820 countsByYear W20004938202019 @default.
• W2000493820 countsByYear W20004938202020 @default.
• W2000493820 countsByYear W20004938202021 @default.
• W2000493820 countsByYear W20004938202022 @default.
• W2000493820 countsByYear W20004938202023 @default.
• W2000493820 crossrefType "journal-article" @default.
• W2000493820 hasAuthorship W2000493820A5048023375 @default.
• W2000493820 hasAuthorship W2000493820A5065301160 @default.
• W2000493820 hasAuthorship W2000493820A5071434327 @default.
• W2000493820 hasAuthorship W2000493820A5087060170 @default.
• W2000493820 hasBestOaLocation W20004938201 @default.
• W2000493820 hasConcept C126322002 @default.
• W2000493820 hasConcept C13348194 @default.
• W2000493820 hasConcept C134018914 @default.
• W2000493820 hasConcept C137183658 @default.
• W2000493820 hasConcept C15490471 @default.
• W2000493820 hasConcept C170493617 @default.
• W2000493820 hasConcept C2776312488 @default.
• W2000493820 hasConcept C2776814716 @default.
• W2000493820 hasConcept C2776885963 @default.
• W2000493820 hasConcept C2777953023 @default.
• W2000493820 hasConcept C2778399450 @default.
• W2000493820 hasConcept C2778468602 @default.
• W2000493820 hasConcept C2778938600 @default.
• W2000493820 hasConcept C2779520467 @default.
• W2000493820 hasConcept C2780648677 @default.
• W2000493820 hasConcept C2780938664 @default.
• W2000493820 hasConcept C2780939551 @default.
• W2000493820 hasConcept C2781302539 @default.
• W2000493820 hasConcept C2909480419 @default.
• W2000493820 hasConcept C42219234 @default.
• W2000493820 hasConcept C513476851 @default.
• W2000493820 hasConcept C529278444 @default.
• W2000493820 hasConcept C71924100 @default.
• W2000493820 hasConcept C84393581 @default.
• W2000493820 hasConcept C98274493 @default.
• W2000493820 hasConceptScore W2000493820C126322002 @default.
• W2000493820 hasConceptScore W2000493820C13348194 @default.
• W2000493820 hasConceptScore W2000493820C134018914 @default.
• W2000493820 hasConceptScore W2000493820C137183658 @default.
• W2000493820 hasConceptScore W2000493820C15490471 @default.
• W2000493820 hasConceptScore W2000493820C170493617 @default.
• W2000493820 hasConceptScore W2000493820C2776312488 @default.
• W2000493820 hasConceptScore W2000493820C2776814716 @default.
• W2000493820 hasConceptScore W2000493820C2776885963 @default.
• W2000493820 hasConceptScore W2000493820C2777953023 @default.

• next