FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000494074> ?p ?o ?g. }

• W2000494074 endingPage "74" @default.
• W2000494074 startingPage "67" @default.
• W2000494074 abstract "Abstract Smooth muscle cell migration, proliferation, and deposition of extracellular matrix are key events in atherogenesis and restenosis development. To explore the mechanisms that regulate smooth muscle cell function, we have investigated whether perlecan, a basement membrane heparan sulfate proteoglycan, modulates interaction between smooth muscle cells and other matrix components. A combined substrate of fibronectin and perlecan showed a reduced adhesion of rat aortic smooth muscle cells by 70–90% in comparison to fibronectin alone. In contrast, perlecan did not interfere with cell adhesion to laminin. Heparinase treated perlecan lost 60% of its anti‐adhesive effect. Furthermore, heparan sulfate as well as heparin reduced smooth muscle cell adhesion when combined with fibronectin whereas neither hyaluronan nor chondroitin sulfate had any anti‐adhesive effects. Addition of heparin as a second coating to a preformed fibronectin matrix did not affect cell adhesion. Cell adhesion to the 105‐ and 120 kDa cell‐binding fragments of fibronectin, lacking the main heparin‐binding domains, was also inhibited by heparin. In addition, co‐coating of fibronectin and 3 H‐heparin showed that heparin was not even incorporated in the substrate. Morphologically, smooth muscle cells adhering to a substrate prepared by co‐coating of fibronectin and perlecan or heparin were small, rounded, lacked focal contacts, and showed poorly developed stress fibers of actin. The results show that the heparan sulfate chains of perlecan lead to altered interactions between smooth muscle cells and fibronectin, possibly due to conformational changes in the fibronectin molecule. Such interactions may influence smooth muscle cell function in atherogenesis and vascular repair processes. © 2001 Wiley‐Liss, Inc." @default.
• W2000494074 created "2016-06-24" @default.
• W2000494074 creator A5003525208 @default.
• W2000494074 creator A5012025016 @default.
• W2000494074 creator A5035268339 @default.
• W2000494074 creator A5064950593 @default.
• W2000494074 creator A5067847626 @default.
• W2000494074 creator A5082088034 @default.
• W2000494074 date "2001-05-25" @default.
• W2000494074 modified "2023-10-11" @default.
• W2000494074 title "Perlecan inhibits smooth muscle cell adhesion to fibronectin: Role of heparan sulfate" @default.
• W2000494074 cites W1487106955 @default.
• W2000494074 cites W1501588760 @default.
• W2000494074 cites W1968465587 @default.
• W2000494074 cites W1974262404 @default.
• W2000494074 cites W1977798903 @default.
• W2000494074 cites W1980617596 @default.
• W2000494074 cites W1991261634 @default.
• W2000494074 cites W1992615592 @default.
• W2000494074 cites W1997120671 @default.
• W2000494074 cites W2001991657 @default.
• W2000494074 cites W2002256788 @default.
• W2000494074 cites W2005760069 @default.
• W2000494074 cites W2008251866 @default.
• W2000494074 cites W2023105561 @default.
• W2000494074 cites W2034378488 @default.
• W2000494074 cites W2047721737 @default.
• W2000494074 cites W2050978899 @default.
• W2000494074 cites W2054255117 @default.
• W2000494074 cites W2058354015 @default.
• W2000494074 cites W2087027565 @default.
• W2000494074 cites W2100837269 @default.
• W2000494074 cites W2137544603 @default.
• W2000494074 cites W2140969448 @default.
• W2000494074 cites W2144328981 @default.
• W2000494074 cites W2151426663 @default.
• W2000494074 cites W2152264767 @default.
• W2000494074 cites W2153852857 @default.
• W2000494074 cites W2162093697 @default.
• W2000494074 cites W2322832538 @default.
• W2000494074 cites W2410751280 @default.
• W2000494074 cites W297069671 @default.
• W2000494074 cites W34966227 @default.
• W2000494074 cites W4256475235 @default.
• W2000494074 doi "https://doi.org/10.1002/jcp.1094" @default.
• W2000494074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11382923" @default.
• W2000494074 hasPublicationYear "2001" @default.
• W2000494074 type Work @default.
• W2000494074 sameAs 2000494074 @default.
• W2000494074 citedByCount "34" @default.
• W2000494074 countsByYear W20004940742014 @default.
• W2000494074 countsByYear W20004940742015 @default.
• W2000494074 countsByYear W20004940742017 @default.
• W2000494074 countsByYear W20004940742018 @default.
• W2000494074 countsByYear W20004940742019 @default.
• W2000494074 countsByYear W20004940742021 @default.
• W2000494074 countsByYear W20004940742023 @default.
• W2000494074 crossrefType "journal-article" @default.
• W2000494074 hasAuthorship W2000494074A5003525208 @default.
• W2000494074 hasAuthorship W2000494074A5012025016 @default.
• W2000494074 hasAuthorship W2000494074A5035268339 @default.
• W2000494074 hasAuthorship W2000494074A5064950593 @default.
• W2000494074 hasAuthorship W2000494074A5067847626 @default.
• W2000494074 hasAuthorship W2000494074A5082088034 @default.
• W2000494074 hasConcept C1491633281 @default.
• W2000494074 hasConcept C153074725 @default.
• W2000494074 hasConcept C178790620 @default.
• W2000494074 hasConcept C185592680 @default.
• W2000494074 hasConcept C189165786 @default.
• W2000494074 hasConcept C22731427 @default.
• W2000494074 hasConcept C2776193487 @default.
• W2000494074 hasConcept C2777557582 @default.
• W2000494074 hasConcept C2778041096 @default.
• W2000494074 hasConcept C2779553658 @default.
• W2000494074 hasConcept C2779814568 @default.
• W2000494074 hasConcept C55493867 @default.
• W2000494074 hasConcept C84416704 @default.
• W2000494074 hasConcept C85789140 @default.
• W2000494074 hasConcept C86492073 @default.
• W2000494074 hasConcept C86803240 @default.
• W2000494074 hasConcept C95444343 @default.
• W2000494074 hasConceptScore W2000494074C1491633281 @default.
• W2000494074 hasConceptScore W2000494074C153074725 @default.
• W2000494074 hasConceptScore W2000494074C178790620 @default.
• W2000494074 hasConceptScore W2000494074C185592680 @default.
• W2000494074 hasConceptScore W2000494074C189165786 @default.
• W2000494074 hasConceptScore W2000494074C22731427 @default.
• W2000494074 hasConceptScore W2000494074C2776193487 @default.
• W2000494074 hasConceptScore W2000494074C2777557582 @default.
• W2000494074 hasConceptScore W2000494074C2778041096 @default.
• W2000494074 hasConceptScore W2000494074C2779553658 @default.
• W2000494074 hasConceptScore W2000494074C2779814568 @default.
• W2000494074 hasConceptScore W2000494074C55493867 @default.
• W2000494074 hasConceptScore W2000494074C84416704 @default.
• W2000494074 hasConceptScore W2000494074C85789140 @default.
• W2000494074 hasConceptScore W2000494074C86492073 @default.
• W2000494074 hasConceptScore W2000494074C86803240 @default.
• W2000494074 hasConceptScore W2000494074C95444343 @default.

• next