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- W2000497143 abstract "No study has ever examined the effect of 5-HT 7 receptor agonists on nociception by using 5-HT 7 receptor knockout mice. Basal sensitivity to noxious heat stimuli and formalin-induced nociception in both phase I and II of the formalin test did not differ in 5-HT 7 receptor knockout mice and paired wild-type controls. Similarly, there was no significant difference in basal body temperature between both genotypes. Subcutaneous administration of 5-HT 7 receptor agonists AS-19 (10 mg/kg), E-57431 (10 mg/kg), and E-55888 (20 mg/kg) significantly reduced formalin-induced licking/biting behavior during the phase II of the test in wild-type but not in 5-HT 7 receptor knockout mice. At these active analgesic doses, none of the three 5-HT 7 receptor agonists modified the basal body temperature neither in wild-type nor in 5-HT 7 receptor knockout mice. However, a significant decrease in body temperature was observed at a higher dose (20 mg/kg) of AS-19 and E-57431 in both genotypes. Our data strongly suggest that the 5-HT 7 receptor agonists AS-19, E-57431, and E-55888 produce antinociception in the formalin test by activating 5-HT 7 receptors. These results also strengthen the idea that the 5-HT 7 receptor plays a role in thermoregulation, but by acting in concert with other receptors." @default.
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- W2000497143 date "2012-01-01" @default.
- W2000497143 modified "2023-09-22" @default.
- W2000497143 title "Assessment of 5-HT<sub>7</sub>Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice" @default.
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- W2000497143 doi "https://doi.org/10.1155/2012/312041" @default.
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