Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000497345> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2000497345 endingPage "233" @default.
- W2000497345 startingPage "229" @default.
- W2000497345 abstract "Systemic lupus erythematosus (SLE) is still regarded as a paradigm for autoimmune diseases, an Everest which if conquered would allow the solution of other unsolved problems in autoimmunity. Thus, interest in this issue is not confined to physicians and medical scientists who deal directly with patients with this disorder. The seach for viral causes of SLE has continued despite many decades of largely fruitless endeavour. Indeed, interest in this possibility has been sustained mainly by the discovery of the many mechanisms in natural infections and model systems by which persistently infective viruses are able to evade elimination by host immune defences and to stimulate autoimmune phenomena or disease. 1,2 Of particular relevance to the immunopathogenesis of SLE are those viral infections which induce the characteristic spectrum of anti-nuclear and related autoantibodies and also lesions related to immune complex deposition and cytokine-induced inflammation resembling those characteristic of human SLE. For example, viral infections reveal cryptic auto-antigens to the immune system, thereby allowing tolerance to these antigens to be broken. 3 The inflammatory reaction accompanying many viral infections generates high local concentrations of pro-inflammatory cytokines with subsequent autoantibody production. 4,5 Such findings mirror the many situations in which transgenic manipulation of constitutive cytokine production is followed by autoimmune disorders. More simplistically, in clinical medicine parvovirus B19 infection is a telling example of a situation in which an ubiquitous agent induces acute clinical features and immunological abnormalities closely resembling SLE, often over a period of many months. 6" @default.
- W2000497345 created "2016-06-24" @default.
- W2000497345 creator A5085104048 @default.
- W2000497345 date "2000-05-01" @default.
- W2000497345 modified "2023-10-16" @default.
- W2000497345 title "Systemic Lupus Erythematosus — is a Viral Aetiology a Credible Hypothesis?" @default.
- W2000497345 cites W1597614503 @default.
- W2000497345 cites W1657438214 @default.
- W2000497345 cites W1676204945 @default.
- W2000497345 cites W1974920235 @default.
- W2000497345 cites W1978009718 @default.
- W2000497345 cites W1996907158 @default.
- W2000497345 cites W2001574120 @default.
- W2000497345 cites W2003707587 @default.
- W2000497345 cites W2006176779 @default.
- W2000497345 cites W2008598223 @default.
- W2000497345 cites W2011396755 @default.
- W2000497345 cites W2014675147 @default.
- W2000497345 cites W2016657054 @default.
- W2000497345 cites W2021953741 @default.
- W2000497345 cites W2023575876 @default.
- W2000497345 cites W2025202479 @default.
- W2000497345 cites W2027962748 @default.
- W2000497345 cites W2028055810 @default.
- W2000497345 cites W2028247424 @default.
- W2000497345 cites W2032726334 @default.
- W2000497345 cites W2032989968 @default.
- W2000497345 cites W2034020663 @default.
- W2000497345 cites W2037650755 @default.
- W2000497345 cites W2039616622 @default.
- W2000497345 cites W2041009078 @default.
- W2000497345 cites W2058400152 @default.
- W2000497345 cites W2068002332 @default.
- W2000497345 cites W2071643016 @default.
- W2000497345 cites W2077171460 @default.
- W2000497345 cites W2078231720 @default.
- W2000497345 cites W2078252602 @default.
- W2000497345 cites W2100841070 @default.
- W2000497345 cites W2113926347 @default.
- W2000497345 cites W2145171404 @default.
- W2000497345 cites W2146203649 @default.
- W2000497345 cites W2325251847 @default.
- W2000497345 cites W2326896496 @default.
- W2000497345 cites W2092337142 @default.
- W2000497345 doi "https://doi.org/10.1053/jinf.2000.0670" @default.
- W2000497345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10908016" @default.
- W2000497345 hasPublicationYear "2000" @default.
- W2000497345 type Work @default.
- W2000497345 sameAs 2000497345 @default.
- W2000497345 citedByCount "30" @default.
- W2000497345 countsByYear W20004973452012 @default.
- W2000497345 countsByYear W20004973452013 @default.
- W2000497345 countsByYear W20004973452015 @default.
- W2000497345 countsByYear W20004973452018 @default.
- W2000497345 crossrefType "journal-article" @default.
- W2000497345 hasAuthorship W2000497345A5085104048 @default.
- W2000497345 hasConcept C126322002 @default.
- W2000497345 hasConcept C137627325 @default.
- W2000497345 hasConcept C159047783 @default.
- W2000497345 hasConcept C159654299 @default.
- W2000497345 hasConcept C203014093 @default.
- W2000497345 hasConcept C2775915377 @default.
- W2000497345 hasConcept C71924100 @default.
- W2000497345 hasConceptScore W2000497345C126322002 @default.
- W2000497345 hasConceptScore W2000497345C137627325 @default.
- W2000497345 hasConceptScore W2000497345C159047783 @default.
- W2000497345 hasConceptScore W2000497345C159654299 @default.
- W2000497345 hasConceptScore W2000497345C203014093 @default.
- W2000497345 hasConceptScore W2000497345C2775915377 @default.
- W2000497345 hasConceptScore W2000497345C71924100 @default.
- W2000497345 hasIssue "3" @default.
- W2000497345 hasLocation W20004973451 @default.
- W2000497345 hasLocation W20004973452 @default.
- W2000497345 hasOpenAccess W2000497345 @default.
- W2000497345 hasPrimaryLocation W20004973451 @default.
- W2000497345 hasRelatedWork W2008908422 @default.
- W2000497345 hasRelatedWork W208399605 @default.
- W2000497345 hasRelatedWork W2377142024 @default.
- W2000497345 hasRelatedWork W2412965123 @default.
- W2000497345 hasRelatedWork W2465854091 @default.
- W2000497345 hasRelatedWork W2902959513 @default.
- W2000497345 hasRelatedWork W3002986063 @default.
- W2000497345 hasRelatedWork W4237982933 @default.
- W2000497345 hasRelatedWork W4322705554 @default.
- W2000497345 hasRelatedWork W4322722809 @default.
- W2000497345 hasVolume "40" @default.
- W2000497345 isParatext "false" @default.
- W2000497345 isRetracted "false" @default.
- W2000497345 magId "2000497345" @default.
- W2000497345 workType "article" @default.