Matches in SemOpenAlex for { <https://semopenalex.org/work/W200049864> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W200049864 endingPage "70" @default.
- W200049864 startingPage "560" @default.
- W200049864 abstract "In a group of adult volunteers, pharmacokinetic profiles of five cephalosporins were correlated with their minimal inhibitory concentrations (MICs90) against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter aerogenes. Subjects received the following intravenous regimens in a randomized, crossover fashion: (1) 0.5 gm, 1 gm, or 2 gm of cefazolin; (2) 2 gm of cephalothin; (3) 1 gm of cephapirin; (4) 1 gm of cefoxitin; or (5) 0.5 gm of cefamandole. The 500-mg dose of cefazolin produced serum concentrations that exceeded those of any of the other cephalosporins at 0.5, 1, 2, 4, and 6 hours after administration. The area under the curve for this dose of cefazolin was at least twice that of any of the other antibiotics. Two hours after a 500-mg dose of cefazolin, serum levels exceeded the MIC90 for all seven groups of pathogens; at six hours, the 500-mg dose of cefazolin continued to achieve serum levels above the MIC90 against the majority of bacterial groups. In contrast, at two hours after administration none of the other cephalosporins maintained serum levels above the MIC90 for all pathogens; at six hours, the levels of cephapirin were adequate to inhibit the two streptococci, but serum levels of all other cephalosporins were inadequate to inhibit any of the pathogens. These data indicate that a 500-mg dose of cefazolin maintains serum levels above the MICs90 longer than any of the other cephalosporins tested and support the use of a 500-mg dose of cefazolin every eight hours for surgical prophylaxis and treatment of most community-acquired infections. Such a comparatively low dosage offers substantial savings to both patient and hospital." @default.
- W200049864 created "2016-06-24" @default.
- W200049864 creator A5006277151 @default.
- W200049864 creator A5009069306 @default.
- W200049864 creator A5022784093 @default.
- W200049864 creator A5038084931 @default.
- W200049864 creator A5039711971 @default.
- W200049864 creator A5039843606 @default.
- W200049864 creator A5042261168 @default.
- W200049864 creator A5065980973 @default.
- W200049864 creator A5071196571 @default.
- W200049864 creator A5076368459 @default.
- W200049864 date "1984-01-01" @default.
- W200049864 modified "2023-09-23" @default.
- W200049864 title "Five cephalosporins: pharmacokinetics and their relation to antibacterial potency." @default.
- W200049864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6467282" @default.
- W200049864 hasPublicationYear "1984" @default.
- W200049864 type Work @default.
- W200049864 sameAs 200049864 @default.
- W200049864 citedByCount "0" @default.
- W200049864 crossrefType "journal-article" @default.
- W200049864 hasAuthorship W200049864A5006277151 @default.
- W200049864 hasAuthorship W200049864A5009069306 @default.
- W200049864 hasAuthorship W200049864A5022784093 @default.
- W200049864 hasAuthorship W200049864A5038084931 @default.
- W200049864 hasAuthorship W200049864A5039711971 @default.
- W200049864 hasAuthorship W200049864A5039843606 @default.
- W200049864 hasAuthorship W200049864A5042261168 @default.
- W200049864 hasAuthorship W200049864A5065980973 @default.
- W200049864 hasAuthorship W200049864A5071196571 @default.
- W200049864 hasAuthorship W200049864A5076368459 @default.
- W200049864 hasConcept C112705442 @default.
- W200049864 hasConcept C2776124114 @default.
- W200049864 hasConcept C2778039505 @default.
- W200049864 hasConcept C2778353156 @default.
- W200049864 hasConcept C2778719061 @default.
- W200049864 hasConcept C2779233340 @default.
- W200049864 hasConcept C2779489039 @default.
- W200049864 hasConcept C2780463255 @default.
- W200049864 hasConcept C2781253189 @default.
- W200049864 hasConcept C501593827 @default.
- W200049864 hasConcept C523546767 @default.
- W200049864 hasConcept C54355233 @default.
- W200049864 hasConcept C64778159 @default.
- W200049864 hasConcept C71924100 @default.
- W200049864 hasConcept C86803240 @default.
- W200049864 hasConcept C89423630 @default.
- W200049864 hasConcept C98274493 @default.
- W200049864 hasConceptScore W200049864C112705442 @default.
- W200049864 hasConceptScore W200049864C2776124114 @default.
- W200049864 hasConceptScore W200049864C2778039505 @default.
- W200049864 hasConceptScore W200049864C2778353156 @default.
- W200049864 hasConceptScore W200049864C2778719061 @default.
- W200049864 hasConceptScore W200049864C2779233340 @default.
- W200049864 hasConceptScore W200049864C2779489039 @default.
- W200049864 hasConceptScore W200049864C2780463255 @default.
- W200049864 hasConceptScore W200049864C2781253189 @default.
- W200049864 hasConceptScore W200049864C501593827 @default.
- W200049864 hasConceptScore W200049864C523546767 @default.
- W200049864 hasConceptScore W200049864C54355233 @default.
- W200049864 hasConceptScore W200049864C64778159 @default.
- W200049864 hasConceptScore W200049864C71924100 @default.
- W200049864 hasConceptScore W200049864C86803240 @default.
- W200049864 hasConceptScore W200049864C89423630 @default.
- W200049864 hasConceptScore W200049864C98274493 @default.
- W200049864 hasIssue "4" @default.
- W200049864 hasLocation W2000498641 @default.
- W200049864 hasOpenAccess W200049864 @default.
- W200049864 hasPrimaryLocation W2000498641 @default.
- W200049864 hasRelatedWork W1983753053 @default.
- W200049864 hasRelatedWork W200049864 @default.
- W200049864 hasRelatedWork W2040687071 @default.
- W200049864 hasRelatedWork W2046323179 @default.
- W200049864 hasRelatedWork W2080505396 @default.
- W200049864 hasRelatedWork W2104746097 @default.
- W200049864 hasRelatedWork W2108080066 @default.
- W200049864 hasRelatedWork W2320576317 @default.
- W200049864 hasRelatedWork W2409865412 @default.
- W200049864 hasRelatedWork W2415000204 @default.
- W200049864 hasVolume "6" @default.
- W200049864 isParatext "false" @default.
- W200049864 isRetracted "false" @default.
- W200049864 magId "200049864" @default.
- W200049864 workType "article" @default.