Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000500071> ?p ?o ?g. }
- W2000500071 endingPage "982" @default.
- W2000500071 startingPage "977" @default.
- W2000500071 abstract "Background. Renal dysfunction (RD) is one of the most significant long-term complications of heart transplantation (HT). Although RD is generally attributed to a direct effect of calcineurin inhibitors, it is more probable that multiple factors contribute to its development. The aim of this study was to search for predictor variables of RD at 1 year after HT. Methods. Three hundred sixteen consecutive HT patients were evaluated. The relationship between RD at 1 year (glomerular filtration rate <60 mL/min/1.73 m2), and pretransplant and 1-year follow-up variables was analyzed. Results. At 1 year following HT, 181 patients (57%) had a glomerular filtration rate of <60 mL/min/1.73 m2. On multivariate analysis, pretransplant serum creatinine values (odds ratio [OR] 5.106, 95% confidence interval [CI]: 2.35–11.09, P=0.0001) and cytomegalovirus (CMV) infection (OR 2.04, 95% CI: 1.08–3.83, P=0.027) were significant predictors of RD, and diabetes mellitus was almost significant (OR 1.65, 95% CI: 0.98–2.76, P=0.055). Variables protective against RD were induction therapy with interleukin-2 receptor antagonists versus muromonab-CD3 (OR 0.389, 95% CI: 0.24–0.61, P=0.0001), maintenance treatment with mycophenolate mofetil versus azathioprine (OR 0.42, 95% CI: 0.26–0.68, P=0.0001), and CMV antiviral prophylaxis (OR 0.38, 95% CI: 0.17–0.68, P=0.021). Conclusions. Fifty-seven percent of HT patients had RD at 1 year posttransplant. RD was associated with pretransplant serum creatinine values, CMV infection, and diabetes mellitus. Induction with interleukin-2 receptor antagonists, treatment with mycophenolate mofetil, and antiviral prophylaxis for CMV infection all helped maintain renal function in this cohort of HT patients." @default.
- W2000500071 created "2016-06-24" @default.
- W2000500071 creator A5002733097 @default.
- W2000500071 creator A5007441004 @default.
- W2000500071 creator A5018431810 @default.
- W2000500071 creator A5020134567 @default.
- W2000500071 creator A5021301235 @default.
- W2000500071 creator A5025012765 @default.
- W2000500071 creator A5039955059 @default.
- W2000500071 creator A5046758219 @default.
- W2000500071 creator A5055999164 @default.
- W2000500071 creator A5060917587 @default.
- W2000500071 date "2010-04-27" @default.
- W2000500071 modified "2023-09-26" @default.
- W2000500071 title "Predictors of Renal Dysfunction at 1 Year in Heart Transplant Patients" @default.
- W2000500071 cites W1976157256 @default.
- W2000500071 cites W1985653248 @default.
- W2000500071 cites W1988326229 @default.
- W2000500071 cites W1993745210 @default.
- W2000500071 cites W2012548293 @default.
- W2000500071 cites W2024224095 @default.
- W2000500071 cites W2028101364 @default.
- W2000500071 cites W2036525523 @default.
- W2000500071 cites W2045608993 @default.
- W2000500071 cites W2050583907 @default.
- W2000500071 cites W2066754455 @default.
- W2000500071 cites W2076662121 @default.
- W2000500071 cites W2087154697 @default.
- W2000500071 cites W2091036236 @default.
- W2000500071 cites W2103437603 @default.
- W2000500071 cites W2124752940 @default.
- W2000500071 cites W2134672034 @default.
- W2000500071 cites W2136905810 @default.
- W2000500071 cites W2152078955 @default.
- W2000500071 cites W2153851381 @default.
- W2000500071 cites W2155322359 @default.
- W2000500071 cites W2156162099 @default.
- W2000500071 cites W2158883043 @default.
- W2000500071 cites W2521699365 @default.
- W2000500071 doi "https://doi.org/10.1097/tp.0b013e3181cbe024" @default.
- W2000500071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20405579" @default.
- W2000500071 hasPublicationYear "2010" @default.
- W2000500071 type Work @default.
- W2000500071 sameAs 2000500071 @default.
- W2000500071 citedByCount "23" @default.
- W2000500071 countsByYear W20005000712013 @default.
- W2000500071 countsByYear W20005000712014 @default.
- W2000500071 countsByYear W20005000712015 @default.
- W2000500071 countsByYear W20005000712016 @default.
- W2000500071 countsByYear W20005000712018 @default.
- W2000500071 countsByYear W20005000712020 @default.
- W2000500071 countsByYear W20005000712021 @default.
- W2000500071 countsByYear W20005000712022 @default.
- W2000500071 crossrefType "journal-article" @default.
- W2000500071 hasAuthorship W2000500071A5002733097 @default.
- W2000500071 hasAuthorship W2000500071A5007441004 @default.
- W2000500071 hasAuthorship W2000500071A5018431810 @default.
- W2000500071 hasAuthorship W2000500071A5020134567 @default.
- W2000500071 hasAuthorship W2000500071A5021301235 @default.
- W2000500071 hasAuthorship W2000500071A5025012765 @default.
- W2000500071 hasAuthorship W2000500071A5039955059 @default.
- W2000500071 hasAuthorship W2000500071A5046758219 @default.
- W2000500071 hasAuthorship W2000500071A5055999164 @default.
- W2000500071 hasAuthorship W2000500071A5060917587 @default.
- W2000500071 hasBestOaLocation W20005000711 @default.
- W2000500071 hasConcept C126322002 @default.
- W2000500071 hasConcept C126894567 @default.
- W2000500071 hasConcept C128057223 @default.
- W2000500071 hasConcept C134018914 @default.
- W2000500071 hasConcept C141071460 @default.
- W2000500071 hasConcept C156957248 @default.
- W2000500071 hasConcept C159641895 @default.
- W2000500071 hasConcept C2776760755 @default.
- W2000500071 hasConcept C2778849806 @default.
- W2000500071 hasConcept C2779134260 @default.
- W2000500071 hasConcept C2780306776 @default.
- W2000500071 hasConcept C2911091166 @default.
- W2000500071 hasConcept C44249647 @default.
- W2000500071 hasConcept C555293320 @default.
- W2000500071 hasConcept C71924100 @default.
- W2000500071 hasConcept C90924648 @default.
- W2000500071 hasConceptScore W2000500071C126322002 @default.
- W2000500071 hasConceptScore W2000500071C126894567 @default.
- W2000500071 hasConceptScore W2000500071C128057223 @default.
- W2000500071 hasConceptScore W2000500071C134018914 @default.
- W2000500071 hasConceptScore W2000500071C141071460 @default.
- W2000500071 hasConceptScore W2000500071C156957248 @default.
- W2000500071 hasConceptScore W2000500071C159641895 @default.
- W2000500071 hasConceptScore W2000500071C2776760755 @default.
- W2000500071 hasConceptScore W2000500071C2778849806 @default.
- W2000500071 hasConceptScore W2000500071C2779134260 @default.
- W2000500071 hasConceptScore W2000500071C2780306776 @default.
- W2000500071 hasConceptScore W2000500071C2911091166 @default.
- W2000500071 hasConceptScore W2000500071C44249647 @default.
- W2000500071 hasConceptScore W2000500071C555293320 @default.
- W2000500071 hasConceptScore W2000500071C71924100 @default.
- W2000500071 hasConceptScore W2000500071C90924648 @default.
- W2000500071 hasIssue "8" @default.