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• W2000500817 abstract "Abstract : In this study we have used the presynaptic‐rich rat cerebrocortical synaptosomal preparation to investigate the proteolytic cleavage of the amyloid precursor protein (AβPP) by the α‐secretase pathway within the βA4 domain to generate a soluble secreted N‐terminal fragment (AβPP s ). AβPP was detected in crude cortical synaptosomal membranes, although at a lower density than that observed in whole‐tissue homogenates. Protein kinase C (PKC) activation induced a translocation of the conventional PKC isoform β1 and novel PKCε from cytosol to membrane fractions, but there was no alteration in the proportion of AβPP associated with the Tritonsoluble and ‐insoluble fractions. AβPP s was constitutively secreted from cortical synaptosomes, with this secretion being enhanced significantly by the direct activation of PKC with phorbol ester. The PKC‐induced secretion of AβPP s was only partially blocked by the PKC inhibitor GF109203X (2.5 μ M ), whereas the phosphorylation of the myristoylated alanine‐rich C kinase substrate (MARCKS) protein was significantly inhibited by GF109203X. The differential sensitivities of the MARCKS phosphorylation and AβPP s secretion to GF109203X may imply that different PKC isoforms are involved in these two events in the synaptosomal system. These findings strongly suggest that the α‐secretase activity leading to the secretion of AβPP s can occur at the level of the presynaptic terminal." @default.
• W2000500817 created "2016-06-24" @default.
• W2000500817 creator A5042299850 @default.
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• W2000500817 date "1999-01-01" @default.
• W2000500817 modified "2023-10-17" @default.
• W2000500817 title "Protein Kinase C Activation Potentiates the Rapid Secretion of the Amyloid Precursor Protein from Rat Cortical Synaptosomes" @default.
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• W2000500817 doi "https://doi.org/10.1046/j.1471-4159.1999.0720273.x" @default.
• W2000500817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9886079" @default.
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