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• W2000500963 abstract "Alperujo, an antioxidant-rich by-product of olive oil extraction, could protect β-cells against oxidative damage. Our goal was to study the antioxidant effects of an alperujo extract (AE) on MIN6 β-cells challenged with glucose or hydrogen peroxide. MIN6 β-cells were challenged with glucose (100 mM) or H2O2 (0.15 mM), with or without AE (20 μM phenol). Reactive oxygen species, intracellular iron (Fe), insulin, glucose uptake, and mRNA gene expression of Uncoupling Protein-2 (UCP-2), Thioredoxin (TRDX), p47phox, and the ratio Bax/Bcl-2 were measured. ROS increased when the stressors were incubated with AE (p β-cells with AE tended to protect them against apoptosis, thereby enhancing insulin secretion." @default.
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• W2000500963 date "2014-01-01" @default.
• W2000500963 modified "2023-10-02" @default.
• W2000500963 title "Antioxidant Effects of Alperujo Extract (Arbequina and Frantoio Varieties) on MIN6 <i>β</i>-Cells Subjected to Stress with Glucose or H₂O₂" @default.
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• W2000500963 doi "https://doi.org/10.4236/fns.2014.513139" @default.
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