FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000501611> ?p ?o ?g. }

• W2000501611 endingPage "e12976" @default.
• W2000501611 startingPage "e12976" @default.
• W2000501611 abstract "MicroRNAs play extensive roles in cellular development. Analysis of the microRNA expression pattern during intestinal cell proliferation in early life is likely to unravel molecular mechanisms behind intestinal development and have implications for therapeutic intervention. In this study, we isolated mouse intestinal crypt cells, examined the differences in microRNA expression upon IGF-1 stimulated proliferation and identified miR-103 as a one of the key regulators. Mouse intestinal crypt cells were cultured and treated with IGF-1 for 24 h. MicroRNA microarray showed that multiple microRNAs are regulated by IGF-1, and miR-103 was the most sharply down-regulated. Expression of miR-103 in mouse intestinal crypt cells was confirmed by real-time Q-PCR. Sequence analyses showed that, among the 1040 predicted miR-103 target genes, CCNE1, CDK2, and CREB1 contain complementary sequences to the miR-103 seed region that are conserved between human and mouse. We further demonstrated that miR-103 controls the expression level of these three genes in mouse crypt cells by luciferase assay and immunoblotting assay. Taken together, our data suggest that in mouse intestinal crypt cells, miR-103 is part of the G1/S transition regulatory network, which targets CCNE1, CDK2, and CREB1 during IGF-1 stimulated proliferation." @default.
• W2000501611 created "2016-06-24" @default.
• W2000501611 creator A5071670795 @default.
• W2000501611 creator A5088637450 @default.
• W2000501611 date "2010-09-23" @default.
• W2000501611 modified "2023-10-16" @default.
• W2000501611 title "Global MicroRNA Characterization Reveals That miR-103 Is Involved in IGF-1 Stimulated Mouse Intestinal Cell Proliferation" @default.
• W2000501611 cites W10662613 @default.
• W2000501611 cites W144423133 @default.
• W2000501611 cites W1533335653 @default.
• W2000501611 cites W1546952499 @default.
• W2000501611 cites W177624256 @default.
• W2000501611 cites W1950514687 @default.
• W2000501611 cites W1965157206 @default.
• W2000501611 cites W1966797025 @default.
• W2000501611 cites W1981979731 @default.
• W2000501611 cites W1983183714 @default.
• W2000501611 cites W1985563073 @default.
• W2000501611 cites W1986707765 @default.
• W2000501611 cites W1992525569 @default.
• W2000501611 cites W1994648070 @default.
• W2000501611 cites W1994859327 @default.
• W2000501611 cites W2004101246 @default.
• W2000501611 cites W2005378927 @default.
• W2000501611 cites W2010508270 @default.
• W2000501611 cites W2013444425 @default.
• W2000501611 cites W2036828685 @default.
• W2000501611 cites W2042035919 @default.
• W2000501611 cites W2051353958 @default.
• W2000501611 cites W2065387006 @default.
• W2000501611 cites W2070571588 @default.
• W2000501611 cites W2081098333 @default.
• W2000501611 cites W2090303261 @default.
• W2000501611 cites W2092792683 @default.
• W2000501611 cites W2100668965 @default.
• W2000501611 cites W2108209314 @default.
• W2000501611 cites W2109824367 @default.
• W2000501611 cites W2110065044 @default.
• W2000501611 cites W2112192177 @default.
• W2000501611 cites W2119248051 @default.
• W2000501611 cites W2124498519 @default.
• W2000501611 cites W2128286741 @default.
• W2000501611 cites W2137257434 @default.
• W2000501611 cites W2139449432 @default.
• W2000501611 cites W2152028923 @default.
• W2000501611 cites W2156186883 @default.
• W2000501611 cites W2160697532 @default.
• W2000501611 cites W2166094946 @default.
• W2000501611 cites W2175765352 @default.
• W2000501611 doi "https://doi.org/10.1371/journal.pone.0012976" @default.
• W2000501611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2944884" @default.
• W2000501611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20886090" @default.
• W2000501611 hasPublicationYear "2010" @default.
• W2000501611 type Work @default.
• W2000501611 sameAs 2000501611 @default.
• W2000501611 citedByCount "39" @default.
• W2000501611 countsByYear W20005016112012 @default.
• W2000501611 countsByYear W20005016112013 @default.
• W2000501611 countsByYear W20005016112014 @default.
• W2000501611 countsByYear W20005016112015 @default.
• W2000501611 countsByYear W20005016112016 @default.
• W2000501611 countsByYear W20005016112017 @default.
• W2000501611 countsByYear W20005016112018 @default.
• W2000501611 countsByYear W20005016112019 @default.
• W2000501611 countsByYear W20005016112020 @default.
• W2000501611 countsByYear W20005016112022 @default.
• W2000501611 countsByYear W20005016112023 @default.
• W2000501611 crossrefType "journal-article" @default.
• W2000501611 hasAuthorship W2000501611A5071670795 @default.
• W2000501611 hasAuthorship W2000501611A5088637450 @default.
• W2000501611 hasBestOaLocation W20005016111 @default.
• W2000501611 hasConcept C104317684 @default.
• W2000501611 hasConcept C134018914 @default.
• W2000501611 hasConcept C145059251 @default.
• W2000501611 hasConcept C150194340 @default.
• W2000501611 hasConcept C153911025 @default.
• W2000501611 hasConcept C18431079 @default.
• W2000501611 hasConcept C29537977 @default.
• W2000501611 hasConcept C54355233 @default.
• W2000501611 hasConcept C62112901 @default.
• W2000501611 hasConcept C66090201 @default.
• W2000501611 hasConcept C8415881 @default.
• W2000501611 hasConcept C86803240 @default.
• W2000501611 hasConcept C95444343 @default.
• W2000501611 hasConceptScore W2000501611C104317684 @default.
• W2000501611 hasConceptScore W2000501611C134018914 @default.
• W2000501611 hasConceptScore W2000501611C145059251 @default.
• W2000501611 hasConceptScore W2000501611C150194340 @default.
• W2000501611 hasConceptScore W2000501611C153911025 @default.
• W2000501611 hasConceptScore W2000501611C18431079 @default.
• W2000501611 hasConceptScore W2000501611C29537977 @default.
• W2000501611 hasConceptScore W2000501611C54355233 @default.
• W2000501611 hasConceptScore W2000501611C62112901 @default.
• W2000501611 hasConceptScore W2000501611C66090201 @default.
• W2000501611 hasConceptScore W2000501611C8415881 @default.
• W2000501611 hasConceptScore W2000501611C86803240 @default.
• W2000501611 hasConceptScore W2000501611C95444343 @default.
• W2000501611 hasIssue "9" @default.

• next