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- W2000501612 endingPage "1714" @default.
- W2000501612 startingPage "1691" @default.
- W2000501612 abstract "Mitochondria play a central role in cell survival and cell death. While producing the bulk of intracellular ATP, mitochondrial respiration represents the most prominent source of harmful reactive oxygen species. Mitochondria participate in many anabolic pathways, including cholesterol and nucleotide biosynthesis, yet also control multiple biochemical cascades that contribute to the programmed demise of cells. The tumor suppressor protein p53 is best known for its ability to orchestrate a transcriptional response to stress that can have multiple outcomes, including cell cycle arrest and cell death. p53-mediated tumor suppression, however, also involves transcription-independent mechanisms. Cytoplasmic p53 can physically interact with members of the BCL-2 protein family, thereby promoting mitochondrial membrane permeabilization. Moreover, extranuclear p53 can suppress autophagy, a major prosurvival mechanism that is activated in response to multiple stress conditions. Thirty years have passed since its discovery, and p53 has been ascribed with an ever-increasing number of functions. For instance, p53 has turned out to influence the cell's redox status, by transactivating either anti- or pro-oxidant factors, and to regulate the metabolic switch between glycolysis and aerobic respiration. In this review, we will analyze the mechanisms by which p53 affects the balance between the vital and lethal functions of mitochondria. Antioxid. Redox Signal. 15, 1691–1714." @default.
- W2000501612 created "2016-06-24" @default.
- W2000501612 creator A5053444531 @default.
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- W2000501612 creator A5082814854 @default.
- W2000501612 date "2011-09-15" @default.
- W2000501612 modified "2023-09-26" @default.
- W2000501612 title "Mitochondrial Liaisons of p53" @default.
- W2000501612 cites W1497251274 @default.
- W2000501612 cites W1517681803 @default.
- W2000501612 cites W1544032942 @default.
- W2000501612 cites W1592021885 @default.
- W2000501612 cites W1616121322 @default.
- W2000501612 cites W1644794975 @default.
- W2000501612 cites W1650797637 @default.
- W2000501612 cites W1657827244 @default.
- W2000501612 cites W1680634601 @default.
- W2000501612 cites W1726596043 @default.
- W2000501612 cites W1942214720 @default.
- W2000501612 cites W1964126982 @default.
- W2000501612 cites W1964190328 @default.
- W2000501612 cites W1964483580 @default.
- W2000501612 cites W1964678730 @default.
- W2000501612 cites W1964719993 @default.
- W2000501612 cites W1965611519 @default.
- W2000501612 cites W1965841186 @default.
- W2000501612 cites W1968006317 @default.
- W2000501612 cites W1969370465 @default.
- W2000501612 cites W1970517061 @default.
- W2000501612 cites W1970650626 @default.
- W2000501612 cites W1970667642 @default.
- W2000501612 cites W1971832552 @default.
- W2000501612 cites W1972618720 @default.
- W2000501612 cites W1974064196 @default.
- W2000501612 cites W1975283890 @default.
- W2000501612 cites W1976881265 @default.
- W2000501612 cites W1978310592 @default.
- W2000501612 cites W1979403925 @default.
- W2000501612 cites W1979526109 @default.
- W2000501612 cites W1981079102 @default.
- W2000501612 cites W1981284402 @default.
- W2000501612 cites W1984018823 @default.
- W2000501612 cites W1985191673 @default.
- W2000501612 cites W1986158928 @default.
- W2000501612 cites W1988350032 @default.
- W2000501612 cites W1988463172 @default.
- W2000501612 cites W1989051519 @default.
- W2000501612 cites W1989887575 @default.
- W2000501612 cites W1989936068 @default.
- W2000501612 cites W1990126127 @default.
- W2000501612 cites W1990906920 @default.
- W2000501612 cites W1991075835 @default.
- W2000501612 cites W1991429659 @default.
- W2000501612 cites W1991510903 @default.
- W2000501612 cites W1991622801 @default.
- W2000501612 cites W1991982116 @default.
- W2000501612 cites W1992516982 @default.
- W2000501612 cites W1993079965 @default.
- W2000501612 cites W1993170641 @default.
- W2000501612 cites W1993345208 @default.
- W2000501612 cites W1993702591 @default.
- W2000501612 cites W1994079658 @default.
- W2000501612 cites W1994239968 @default.
- W2000501612 cites W1994411647 @default.
- W2000501612 cites W1995741673 @default.
- W2000501612 cites W1995781927 @default.
- W2000501612 cites W1995856480 @default.
- W2000501612 cites W1995935153 @default.
- W2000501612 cites W1996114270 @default.
- W2000501612 cites W1996177324 @default.
- W2000501612 cites W1996407872 @default.
- W2000501612 cites W1997054509 @default.
- W2000501612 cites W1998643809 @default.
- W2000501612 cites W1998943082 @default.
- W2000501612 cites W1999532278 @default.
- W2000501612 cites W1999653222 @default.
- W2000501612 cites W1999671588 @default.
- W2000501612 cites W2000081372 @default.
- W2000501612 cites W2000834350 @default.
- W2000501612 cites W2001176921 @default.
- W2000501612 cites W2001506328 @default.
- W2000501612 cites W2001824068 @default.
- W2000501612 cites W2002835770 @default.
- W2000501612 cites W2002936090 @default.
- W2000501612 cites W2003167607 @default.
- W2000501612 cites W2003237182 @default.
- W2000501612 cites W2003317927 @default.
- W2000501612 cites W2006099686 @default.
- W2000501612 cites W2007010211 @default.
- W2000501612 cites W2007468662 @default.
- W2000501612 cites W2008715871 @default.
- W2000501612 cites W2008887283 @default.
- W2000501612 cites W2010077871 @default.
- W2000501612 cites W2011727075 @default.
- W2000501612 cites W2011894191 @default.
- W2000501612 cites W2011894210 @default.