Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000501909> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2000501909 endingPage "269a" @default.
- W2000501909 startingPage "269a" @default.
- W2000501909 abstract "Although the natural tendency of proteins is to acquire soluble native-like functional states, they are able to undertake alternative pathways, such as self-association into ordered insoluble amyloid fibrils. The latter are protein aggregates that share common cross-β sheet structures and give rise to various incurable disorders, such as Alzheimer's and Parkinson's diseases. The abnormal self-assembly of amyloid beta (Aβ), an intrinsically disordered peptide, into neurotoxic oligomers and fibrils is strongly associated with Alzheimer's disease, thus prompting a comprehensive search for small compounds capable of inhibiting its aggregation. Although many compounds have been reported with this effect, the mechanisms by which they act are still largely unclear. In the present study, we use Small-Angle X-Ray Scattering (SAXS) as a high-throughput tool to screen an in-house fragment-based library in an attempt to identify new potential inhibitors targeting Aβ aggregation. We follow the fibrillation process of Aβ in solution over time in order to resolve major co-exisiting species and monitor by SAXS the effect of small compounds on these species. This approach is expected to provide molecular insights into Aβ self-assembly mechanism and lead effectively to much needed new treatment options." @default.
- W2000501909 created "2016-06-24" @default.
- W2000501909 creator A5016114566 @default.
- W2000501909 creator A5038452125 @default.
- W2000501909 creator A5064914100 @default.
- W2000501909 creator A5080178613 @default.
- W2000501909 creator A5083468126 @default.
- W2000501909 date "2014-01-01" @default.
- W2000501909 modified "2023-10-18" @default.
- W2000501909 title "Structural and Mechanistic Analyses of the Effects of Small Compounds on Amyloid Beta Self-Assembly" @default.
- W2000501909 doi "https://doi.org/10.1016/j.bpj.2013.11.1579" @default.
- W2000501909 hasPublicationYear "2014" @default.
- W2000501909 type Work @default.
- W2000501909 sameAs 2000501909 @default.
- W2000501909 citedByCount "0" @default.
- W2000501909 crossrefType "journal-article" @default.
- W2000501909 hasAuthorship W2000501909A5016114566 @default.
- W2000501909 hasAuthorship W2000501909A5038452125 @default.
- W2000501909 hasAuthorship W2000501909A5064914100 @default.
- W2000501909 hasAuthorship W2000501909A5080178613 @default.
- W2000501909 hasAuthorship W2000501909A5083468126 @default.
- W2000501909 hasBestOaLocation W20005019091 @default.
- W2000501909 hasConcept C120665830 @default.
- W2000501909 hasConcept C121332964 @default.
- W2000501909 hasConcept C12554922 @default.
- W2000501909 hasConcept C131888329 @default.
- W2000501909 hasConcept C136238340 @default.
- W2000501909 hasConcept C142724271 @default.
- W2000501909 hasConcept C161624437 @default.
- W2000501909 hasConcept C171250308 @default.
- W2000501909 hasConcept C178790620 @default.
- W2000501909 hasConcept C179104552 @default.
- W2000501909 hasConcept C185592680 @default.
- W2000501909 hasConcept C191486275 @default.
- W2000501909 hasConcept C192562407 @default.
- W2000501909 hasConcept C26856880 @default.
- W2000501909 hasConcept C27523624 @default.
- W2000501909 hasConcept C2776156579 @default.
- W2000501909 hasConcept C2777633098 @default.
- W2000501909 hasConcept C2779134260 @default.
- W2000501909 hasConcept C2779281246 @default.
- W2000501909 hasConcept C2994168385 @default.
- W2000501909 hasConcept C3019447875 @default.
- W2000501909 hasConcept C55493867 @default.
- W2000501909 hasConcept C70721500 @default.
- W2000501909 hasConcept C71924100 @default.
- W2000501909 hasConcept C86803240 @default.
- W2000501909 hasConceptScore W2000501909C120665830 @default.
- W2000501909 hasConceptScore W2000501909C121332964 @default.
- W2000501909 hasConceptScore W2000501909C12554922 @default.
- W2000501909 hasConceptScore W2000501909C131888329 @default.
- W2000501909 hasConceptScore W2000501909C136238340 @default.
- W2000501909 hasConceptScore W2000501909C142724271 @default.
- W2000501909 hasConceptScore W2000501909C161624437 @default.
- W2000501909 hasConceptScore W2000501909C171250308 @default.
- W2000501909 hasConceptScore W2000501909C178790620 @default.
- W2000501909 hasConceptScore W2000501909C179104552 @default.
- W2000501909 hasConceptScore W2000501909C185592680 @default.
- W2000501909 hasConceptScore W2000501909C191486275 @default.
- W2000501909 hasConceptScore W2000501909C192562407 @default.
- W2000501909 hasConceptScore W2000501909C26856880 @default.
- W2000501909 hasConceptScore W2000501909C27523624 @default.
- W2000501909 hasConceptScore W2000501909C2776156579 @default.
- W2000501909 hasConceptScore W2000501909C2777633098 @default.
- W2000501909 hasConceptScore W2000501909C2779134260 @default.
- W2000501909 hasConceptScore W2000501909C2779281246 @default.
- W2000501909 hasConceptScore W2000501909C2994168385 @default.
- W2000501909 hasConceptScore W2000501909C3019447875 @default.
- W2000501909 hasConceptScore W2000501909C55493867 @default.
- W2000501909 hasConceptScore W2000501909C70721500 @default.
- W2000501909 hasConceptScore W2000501909C71924100 @default.
- W2000501909 hasConceptScore W2000501909C86803240 @default.
- W2000501909 hasIssue "2" @default.
- W2000501909 hasLocation W20005019091 @default.
- W2000501909 hasOpenAccess W2000501909 @default.
- W2000501909 hasPrimaryLocation W20005019091 @default.
- W2000501909 hasRelatedWork W1969967781 @default.
- W2000501909 hasRelatedWork W1998269242 @default.
- W2000501909 hasRelatedWork W1999109280 @default.
- W2000501909 hasRelatedWork W2000501909 @default.
- W2000501909 hasRelatedWork W2015927989 @default.
- W2000501909 hasRelatedWork W2078734994 @default.
- W2000501909 hasRelatedWork W2115253234 @default.
- W2000501909 hasRelatedWork W2320739632 @default.
- W2000501909 hasRelatedWork W2954612692 @default.
- W2000501909 hasRelatedWork W2943288632 @default.
- W2000501909 hasVolume "106" @default.
- W2000501909 isParatext "false" @default.
- W2000501909 isRetracted "false" @default.
- W2000501909 magId "2000501909" @default.
- W2000501909 workType "article" @default.