Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000502273> ?p ?o ?g. }
- W2000502273 endingPage "42" @default.
- W2000502273 startingPage "25" @default.
- W2000502273 abstract "Mycobacterium leprae is an intracellular obligate parasite that causes leprosy in humans, and it leads to the destruction of peripheral nerves and skin deformation. Here, we report an extensive analysis of the hypothetical proteins (HPs) from M. leprae strain Br4923, assigning their functions to better understand the mechanism of pathogenesis and to search for potential therapeutic interventions. The genome of M. leprae encodes 1604 proteins, of which the functions of 632 are not known (HPs). In this paper, we predicted the probable functions of 312 HPs. First, we classified all HPs into families and subfamilies on the basis of sequence similarity, followed by domain assignment, which provides many clues for their possible function. However, the functions of 320 proteins were not predicted because of low sequence similarity with proteins of known function. Annotated HPs were categorized into enzymes, binding proteins, transporters, and proteins involved in cellular processes. We found several novel proteins whose functions were unknown for M. leprae. These proteins have a requisite association with bacterial virulence and pathogenicity. Finally, our sequence-based analysis will be helpful for further validation and the search for potential drug targets while developing effective drugs to cure leprosy." @default.
- W2000502273 created "2016-06-24" @default.
- W2000502273 creator A5021941753 @default.
- W2000502273 creator A5077513922 @default.
- W2000502273 creator A5087775910 @default.
- W2000502273 date "2015-01-01" @default.
- W2000502273 modified "2023-09-26" @default.
- W2000502273 title "Identification of functional candidates amongst hypothetical proteins of Mycobacterium leprae Br4923, a causative agent of leprosy" @default.
- W2000502273 cites W1034605816 @default.
- W2000502273 cites W1483293912 @default.
- W2000502273 cites W1537641994 @default.
- W2000502273 cites W1559249470 @default.
- W2000502273 cites W1600613454 @default.
- W2000502273 cites W172934802 @default.
- W2000502273 cites W1964264557 @default.
- W2000502273 cites W1973253766 @default.
- W2000502273 cites W1977922844 @default.
- W2000502273 cites W1980330013 @default.
- W2000502273 cites W1982298524 @default.
- W2000502273 cites W1984794455 @default.
- W2000502273 cites W1989447327 @default.
- W2000502273 cites W1991845210 @default.
- W2000502273 cites W1995530145 @default.
- W2000502273 cites W1996478322 @default.
- W2000502273 cites W2001626642 @default.
- W2000502273 cites W2002363009 @default.
- W2000502273 cites W2004949116 @default.
- W2000502273 cites W2006025024 @default.
- W2000502273 cites W2007632362 @default.
- W2000502273 cites W2011986160 @default.
- W2000502273 cites W2012164430 @default.
- W2000502273 cites W2013537779 @default.
- W2000502273 cites W2015271663 @default.
- W2000502273 cites W2016554549 @default.
- W2000502273 cites W2017023111 @default.
- W2000502273 cites W2021517037 @default.
- W2000502273 cites W2022472106 @default.
- W2000502273 cites W2024648909 @default.
- W2000502273 cites W2026405416 @default.
- W2000502273 cites W2038536960 @default.
- W2000502273 cites W2042524660 @default.
- W2000502273 cites W2045839655 @default.
- W2000502273 cites W2048243793 @default.
- W2000502273 cites W2048947602 @default.
- W2000502273 cites W2049312907 @default.
- W2000502273 cites W2052002049 @default.
- W2000502273 cites W2055043387 @default.
- W2000502273 cites W2057597326 @default.
- W2000502273 cites W2060238374 @default.
- W2000502273 cites W2063621561 @default.
- W2000502273 cites W2066332369 @default.
- W2000502273 cites W2074570966 @default.
- W2000502273 cites W2075357243 @default.
- W2000502273 cites W2076150683 @default.
- W2000502273 cites W2088587521 @default.
- W2000502273 cites W2090102101 @default.
- W2000502273 cites W2091448229 @default.
- W2000502273 cites W2094201044 @default.
- W2000502273 cites W2094470156 @default.
- W2000502273 cites W2096173332 @default.
- W2000502273 cites W2097870001 @default.
- W2000502273 cites W2098223336 @default.
- W2000502273 cites W2099946731 @default.
- W2000502273 cites W2101335101 @default.
- W2000502273 cites W2101444163 @default.
- W2000502273 cites W2106359526 @default.
- W2000502273 cites W2108649941 @default.
- W2000502273 cites W2114444962 @default.
- W2000502273 cites W2114690275 @default.
- W2000502273 cites W2118432743 @default.
- W2000502273 cites W2135231521 @default.
- W2000502273 cites W2137450588 @default.
- W2000502273 cites W2138247679 @default.
- W2000502273 cites W2141925828 @default.
- W2000502273 cites W2147526198 @default.
- W2000502273 cites W2152378366 @default.
- W2000502273 cites W2156745542 @default.
- W2000502273 cites W2161257366 @default.
- W2000502273 cites W2162792752 @default.
- W2000502273 cites W2164217177 @default.
- W2000502273 cites W2165797737 @default.
- W2000502273 cites W2169420357 @default.
- W2000502273 cites W2171535756 @default.
- W2000502273 cites W2314268098 @default.
- W2000502273 cites W2326462885 @default.
- W2000502273 cites W2332121203 @default.
- W2000502273 cites W2398906310 @default.
- W2000502273 cites W2465186476 @default.
- W2000502273 cites W4211207211 @default.
- W2000502273 cites W4235848672 @default.
- W2000502273 cites W4247896860 @default.
- W2000502273 doi "https://doi.org/10.1139/gen-2014-0178" @default.
- W2000502273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25985983" @default.
- W2000502273 hasPublicationYear "2015" @default.
- W2000502273 type Work @default.
- W2000502273 sameAs 2000502273 @default.
- W2000502273 citedByCount "15" @default.
- W2000502273 countsByYear W20005022732015 @default.