Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000502468> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2000502468 endingPage "1104" @default.
- W2000502468 startingPage "1098" @default.
- W2000502468 abstract "Chronic congestive heart failure not controlled by conventional therapy was treated with intravenous amrinone, a new non-glycosidic, non-catecholamine cardiotonic agent. Eight patients with New York Heart Association functional class III-IV symptoms were hemodynamically monitored. At peak effect, cardiac index (CI) increased from 1.84 +/- 0.32 to 2.74 +/- 0.44 l/min/m2 (mean +/- SD) (p less than 0.001) and left ventricular filling pressure (LVFP) decreased from 25.8 +/- 6.2 to 19.5 +/- 6.8 mm Hg (p less than 0.05), while heart rate and mean aortic blood pressure did not change significantly. Mean endocardial circumferential fiber shortening (mean Vcf), determined by echocardiography, increased from 0.61 +/- 0.27 to 0.89 +/- 0.34 cir/sec (p less than 0.05). The duration of action after bolus infusion varied from 60--90 minutes. During continuous infusion of amrinone, sustained increases in CI and reductions in LVFP, similar to those at the time of peak effect after bolus administration, were maintained for 180 minutes. These marked cardiotonic effects of amrinone in patients already taking digitalis for severe heart failure occurred without side effects of arrhythmias or altered arterial pressures. The fact that the drug is orally active makes amrinone a v:ry promising inotropic agent for the treatment of chronic heart failure in man." @default.
- W2000502468 created "2016-06-24" @default.
- W2000502468 creator A5015043399 @default.
- W2000502468 creator A5015969064 @default.
- W2000502468 creator A5027929490 @default.
- W2000502468 creator A5032038326 @default.
- W2000502468 creator A5044741265 @default.
- W2000502468 creator A5065904411 @default.
- W2000502468 creator A5076284049 @default.
- W2000502468 creator A5078392367 @default.
- W2000502468 creator A5084406312 @default.
- W2000502468 date "1979-06-01" @default.
- W2000502468 modified "2023-09-24" @default.
- W2000502468 title "Amrinone: a new non-glycosidic, non-adrenergic cardiotonic agent effective in the treatment of intractable myocardial failure in man." @default.
- W2000502468 cites W1968402093 @default.
- W2000502468 cites W2002231995 @default.
- W2000502468 cites W2008793466 @default.
- W2000502468 cites W2033792280 @default.
- W2000502468 cites W2042814103 @default.
- W2000502468 cites W2044322145 @default.
- W2000502468 doi "https://doi.org/10.1161/01.cir.59.6.1098" @default.
- W2000502468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/436202" @default.
- W2000502468 hasPublicationYear "1979" @default.
- W2000502468 type Work @default.
- W2000502468 sameAs 2000502468 @default.
- W2000502468 citedByCount "209" @default.
- W2000502468 countsByYear W20005024682013 @default.
- W2000502468 countsByYear W20005024682015 @default.
- W2000502468 countsByYear W20005024682018 @default.
- W2000502468 countsByYear W20005024682019 @default.
- W2000502468 countsByYear W20005024682020 @default.
- W2000502468 countsByYear W20005024682021 @default.
- W2000502468 countsByYear W20005024682022 @default.
- W2000502468 crossrefType "journal-article" @default.
- W2000502468 hasAuthorship W2000502468A5015043399 @default.
- W2000502468 hasAuthorship W2000502468A5015969064 @default.
- W2000502468 hasAuthorship W2000502468A5027929490 @default.
- W2000502468 hasAuthorship W2000502468A5032038326 @default.
- W2000502468 hasAuthorship W2000502468A5044741265 @default.
- W2000502468 hasAuthorship W2000502468A5065904411 @default.
- W2000502468 hasAuthorship W2000502468A5076284049 @default.
- W2000502468 hasAuthorship W2000502468A5078392367 @default.
- W2000502468 hasAuthorship W2000502468A5084406312 @default.
- W2000502468 hasBestOaLocation W20005024681 @default.
- W2000502468 hasConcept C126322002 @default.
- W2000502468 hasConcept C155710745 @default.
- W2000502468 hasConcept C164705383 @default.
- W2000502468 hasConcept C2777707475 @default.
- W2000502468 hasConcept C2777953023 @default.
- W2000502468 hasConcept C2778198053 @default.
- W2000502468 hasConcept C2779739782 @default.
- W2000502468 hasConcept C31861589 @default.
- W2000502468 hasConcept C42219234 @default.
- W2000502468 hasConcept C43376680 @default.
- W2000502468 hasConcept C71924100 @default.
- W2000502468 hasConcept C84393581 @default.
- W2000502468 hasConceptScore W2000502468C126322002 @default.
- W2000502468 hasConceptScore W2000502468C155710745 @default.
- W2000502468 hasConceptScore W2000502468C164705383 @default.
- W2000502468 hasConceptScore W2000502468C2777707475 @default.
- W2000502468 hasConceptScore W2000502468C2777953023 @default.
- W2000502468 hasConceptScore W2000502468C2778198053 @default.
- W2000502468 hasConceptScore W2000502468C2779739782 @default.
- W2000502468 hasConceptScore W2000502468C31861589 @default.
- W2000502468 hasConceptScore W2000502468C42219234 @default.
- W2000502468 hasConceptScore W2000502468C43376680 @default.
- W2000502468 hasConceptScore W2000502468C71924100 @default.
- W2000502468 hasConceptScore W2000502468C84393581 @default.
- W2000502468 hasIssue "6" @default.
- W2000502468 hasLocation W20005024681 @default.
- W2000502468 hasLocation W20005024682 @default.
- W2000502468 hasOpenAccess W2000502468 @default.
- W2000502468 hasPrimaryLocation W20005024681 @default.
- W2000502468 hasRelatedWork W1994017807 @default.
- W2000502468 hasRelatedWork W2015945165 @default.
- W2000502468 hasRelatedWork W2019228255 @default.
- W2000502468 hasRelatedWork W2073108341 @default.
- W2000502468 hasRelatedWork W2100628652 @default.
- W2000502468 hasRelatedWork W2110803752 @default.
- W2000502468 hasRelatedWork W2152382117 @default.
- W2000502468 hasRelatedWork W2347339300 @default.
- W2000502468 hasRelatedWork W2740274259 @default.
- W2000502468 hasRelatedWork W4211134326 @default.
- W2000502468 hasVolume "59" @default.
- W2000502468 isParatext "false" @default.
- W2000502468 isRetracted "false" @default.
- W2000502468 magId "2000502468" @default.
- W2000502468 workType "article" @default.