Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000503562> ?p ?o ?g. }
- W2000503562 endingPage "93" @default.
- W2000503562 startingPage "86" @default.
- W2000503562 abstract "Acrylamide (ACR) is a well-known neurotoxin in mammalian species that causes neuropathy characterized by ataxia and skeletal muscle weakness. Therefore, ACR-mediated axon damage in the central and peripheral nervous systems is considered to be central-peripheral axonopathy. However, the molecular mechanisms underlying ACR's toxicity to neural progenitor cells are unknown. This study investigated the adverse effects of ACR on mouse multipotent neural progenitor cells and adult hippocampal neurogenesis. ACR significantly reduced the proliferation of neural progenitor cells, and high ACR concentrations induced apoptotic and necrotic cell death. We found that elevated intracellular levels of reactive oxygen species were involved in ACR-mediated cytotoxicity. Interestingly, the administration of ACR to young mice resulted in a significant decrease in the number of newly generated cells in the dentate gyrus of the hippocampus, suggesting an impairment of adult neurogenesis. These results suggest that ACR's deleterious effects on the central nervous system are due to the death of neural progenitor cells and impaired adult neurogenesis." @default.
- W2000503562 created "2016-06-24" @default.
- W2000503562 creator A5030253413 @default.
- W2000503562 creator A5033850014 @default.
- W2000503562 creator A5040250492 @default.
- W2000503562 creator A5048899607 @default.
- W2000503562 creator A5050204085 @default.
- W2000503562 creator A5052433739 @default.
- W2000503562 creator A5055854951 @default.
- W2000503562 creator A5067791161 @default.
- W2000503562 creator A5074986000 @default.
- W2000503562 creator A5075088268 @default.
- W2000503562 creator A5084249893 @default.
- W2000503562 date "2010-03-01" @default.
- W2000503562 modified "2023-10-02" @default.
- W2000503562 title "Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis" @default.
- W2000503562 cites W1582955006 @default.
- W2000503562 cites W1592283056 @default.
- W2000503562 cites W1593725384 @default.
- W2000503562 cites W1966492450 @default.
- W2000503562 cites W1968151995 @default.
- W2000503562 cites W1968747244 @default.
- W2000503562 cites W1969966531 @default.
- W2000503562 cites W1973429276 @default.
- W2000503562 cites W1987107175 @default.
- W2000503562 cites W1991917446 @default.
- W2000503562 cites W1995188451 @default.
- W2000503562 cites W1995479790 @default.
- W2000503562 cites W2004900120 @default.
- W2000503562 cites W2027048265 @default.
- W2000503562 cites W2035245129 @default.
- W2000503562 cites W2035692542 @default.
- W2000503562 cites W2053003157 @default.
- W2000503562 cites W2057608998 @default.
- W2000503562 cites W2061169091 @default.
- W2000503562 cites W2063200805 @default.
- W2000503562 cites W2066619250 @default.
- W2000503562 cites W2069546593 @default.
- W2000503562 cites W2073925710 @default.
- W2000503562 cites W2077375481 @default.
- W2000503562 cites W2079156156 @default.
- W2000503562 cites W2079542122 @default.
- W2000503562 cites W2083103441 @default.
- W2000503562 cites W2086366928 @default.
- W2000503562 cites W2124603205 @default.
- W2000503562 cites W2128291722 @default.
- W2000503562 cites W2133381675 @default.
- W2000503562 cites W2145235967 @default.
- W2000503562 cites W2162540316 @default.
- W2000503562 cites W2168893957 @default.
- W2000503562 cites W2171201258 @default.
- W2000503562 doi "https://doi.org/10.1016/j.toxlet.2009.12.015" @default.
- W2000503562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20035847" @default.
- W2000503562 hasPublicationYear "2010" @default.
- W2000503562 type Work @default.
- W2000503562 sameAs 2000503562 @default.
- W2000503562 citedByCount "83" @default.
- W2000503562 countsByYear W20005035622012 @default.
- W2000503562 countsByYear W20005035622013 @default.
- W2000503562 countsByYear W20005035622014 @default.
- W2000503562 countsByYear W20005035622015 @default.
- W2000503562 countsByYear W20005035622016 @default.
- W2000503562 countsByYear W20005035622017 @default.
- W2000503562 countsByYear W20005035622018 @default.
- W2000503562 countsByYear W20005035622019 @default.
- W2000503562 countsByYear W20005035622020 @default.
- W2000503562 countsByYear W20005035622021 @default.
- W2000503562 countsByYear W20005035622022 @default.
- W2000503562 countsByYear W20005035622023 @default.
- W2000503562 crossrefType "journal-article" @default.
- W2000503562 hasAuthorship W2000503562A5030253413 @default.
- W2000503562 hasAuthorship W2000503562A5033850014 @default.
- W2000503562 hasAuthorship W2000503562A5040250492 @default.
- W2000503562 hasAuthorship W2000503562A5048899607 @default.
- W2000503562 hasAuthorship W2000503562A5050204085 @default.
- W2000503562 hasAuthorship W2000503562A5052433739 @default.
- W2000503562 hasAuthorship W2000503562A5055854951 @default.
- W2000503562 hasAuthorship W2000503562A5067791161 @default.
- W2000503562 hasAuthorship W2000503562A5074986000 @default.
- W2000503562 hasAuthorship W2000503562A5075088268 @default.
- W2000503562 hasAuthorship W2000503562A5084249893 @default.
- W2000503562 hasConcept C136834591 @default.
- W2000503562 hasConcept C148762608 @default.
- W2000503562 hasConcept C169760540 @default.
- W2000503562 hasConcept C201750760 @default.
- W2000503562 hasConcept C2776464000 @default.
- W2000503562 hasConcept C28328180 @default.
- W2000503562 hasConcept C4746552 @default.
- W2000503562 hasConcept C86803240 @default.
- W2000503562 hasConcept C95444343 @default.
- W2000503562 hasConceptScore W2000503562C136834591 @default.
- W2000503562 hasConceptScore W2000503562C148762608 @default.
- W2000503562 hasConceptScore W2000503562C169760540 @default.
- W2000503562 hasConceptScore W2000503562C201750760 @default.
- W2000503562 hasConceptScore W2000503562C2776464000 @default.
- W2000503562 hasConceptScore W2000503562C28328180 @default.
- W2000503562 hasConceptScore W2000503562C4746552 @default.
- W2000503562 hasConceptScore W2000503562C86803240 @default.