Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000503805> ?p ?o ?g. }
- W2000503805 endingPage "2639" @default.
- W2000503805 startingPage "2631" @default.
- W2000503805 abstract "Abstract The mechanisms of bone and blood formation have traditionally been viewed as distinct, unrelated processes, but compelling evidence suggests that they are intertwined. Based on observations that hematopoietic precursors reside close to endosteal surfaces, it was hypothesized that osteoblasts play a central role in hematopoiesis, and it has been shown that osteoblasts produce many factors essential for the survival, renewal, and maturation of hematopoietic stem cells (HSCs). Preceding these observations are studies demonstrating that the disruption or perturbation of normal osteoblastic function has a profound and central role in defining the operational structure of the HSC niche. These observations provide a glimpse of the dimensions and ramifications of HSC-osteoblast interactions. Although more research is required to secure a broader grasp of the molecular mechanisms that govern blood and bone biology, the central role for osteoblasts in hematopoietic stem cell regulation is reviewed herein from the perspectives of (1) historical context; (2) the role of the osteoblast in supporting stem cell survival, proliferation, and maintenance; (3) the participation, if any, of osteoblasts in the creation of a stem cell niche; (4) the molecules that mediate HSC-osteoblast interactions; (5) the role of osteoblasts in stem cell transplantation; and (6) possible future directions for investigation." @default.
- W2000503805 created "2016-06-24" @default.
- W2000503805 creator A5080856310 @default.
- W2000503805 date "2005-04-01" @default.
- W2000503805 modified "2023-10-07" @default.
- W2000503805 title "Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche" @default.
- W2000503805 cites W1501214228 @default.
- W2000503805 cites W151805421 @default.
- W2000503805 cites W1539398892 @default.
- W2000503805 cites W1539758070 @default.
- W2000503805 cites W1544856157 @default.
- W2000503805 cites W1547635899 @default.
- W2000503805 cites W1549257184 @default.
- W2000503805 cites W1561399318 @default.
- W2000503805 cites W1583699618 @default.
- W2000503805 cites W1609235972 @default.
- W2000503805 cites W1674015201 @default.
- W2000503805 cites W1970939239 @default.
- W2000503805 cites W1975025595 @default.
- W2000503805 cites W1979670158 @default.
- W2000503805 cites W1982467518 @default.
- W2000503805 cites W1982721874 @default.
- W2000503805 cites W1983167142 @default.
- W2000503805 cites W1983755448 @default.
- W2000503805 cites W1983974822 @default.
- W2000503805 cites W1986447155 @default.
- W2000503805 cites W1989172510 @default.
- W2000503805 cites W1991766825 @default.
- W2000503805 cites W1991824786 @default.
- W2000503805 cites W1994596418 @default.
- W2000503805 cites W1998336170 @default.
- W2000503805 cites W2004870721 @default.
- W2000503805 cites W2010254035 @default.
- W2000503805 cites W2016490294 @default.
- W2000503805 cites W2016790281 @default.
- W2000503805 cites W2017907565 @default.
- W2000503805 cites W2019913649 @default.
- W2000503805 cites W2024682032 @default.
- W2000503805 cites W2028638661 @default.
- W2000503805 cites W2036287488 @default.
- W2000503805 cites W2037224058 @default.
- W2000503805 cites W2040337853 @default.
- W2000503805 cites W2043029250 @default.
- W2000503805 cites W2044063819 @default.
- W2000503805 cites W2044571094 @default.
- W2000503805 cites W2052739114 @default.
- W2000503805 cites W2053449922 @default.
- W2000503805 cites W2054696286 @default.
- W2000503805 cites W2059704192 @default.
- W2000503805 cites W2060610551 @default.
- W2000503805 cites W2063048904 @default.
- W2000503805 cites W2064252799 @default.
- W2000503805 cites W2070793750 @default.
- W2000503805 cites W2074298033 @default.
- W2000503805 cites W2074494486 @default.
- W2000503805 cites W2074776278 @default.
- W2000503805 cites W2081769332 @default.
- W2000503805 cites W2082620574 @default.
- W2000503805 cites W2084422522 @default.
- W2000503805 cites W2086083531 @default.
- W2000503805 cites W2088236916 @default.
- W2000503805 cites W2099545837 @default.
- W2000503805 cites W2102969047 @default.
- W2000503805 cites W2103365443 @default.
- W2000503805 cites W2106715658 @default.
- W2000503805 cites W2108409970 @default.
- W2000503805 cites W2111234939 @default.
- W2000503805 cites W2114510710 @default.
- W2000503805 cites W2116505368 @default.
- W2000503805 cites W2121627838 @default.
- W2000503805 cites W2127300454 @default.
- W2000503805 cites W2131183827 @default.
- W2000503805 cites W2132274201 @default.
- W2000503805 cites W2134006720 @default.
- W2000503805 cites W2141837666 @default.
- W2000503805 cites W2156505612 @default.
- W2000503805 cites W2159199393 @default.
- W2000503805 cites W2163722698 @default.
- W2000503805 cites W2165521277 @default.
- W2000503805 cites W2200050912 @default.
- W2000503805 cites W2240345672 @default.
- W2000503805 cites W2330136318 @default.
- W2000503805 cites W2402730526 @default.
- W2000503805 cites W2477049901 @default.
- W2000503805 cites W2945232872 @default.
- W2000503805 cites W30927057 @default.
- W2000503805 cites W323623424 @default.
- W2000503805 cites W45150997 @default.
- W2000503805 cites W62788115 @default.
- W2000503805 cites W71612995 @default.
- W2000503805 doi "https://doi.org/10.1182/blood-2004-06-2480" @default.
- W2000503805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15585658" @default.
- W2000503805 hasPublicationYear "2005" @default.
- W2000503805 type Work @default.
- W2000503805 sameAs 2000503805 @default.
- W2000503805 citedByCount "559" @default.
- W2000503805 countsByYear W20005038052012 @default.
- W2000503805 countsByYear W20005038052013 @default.