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- W2000505750 abstract "1 A gas-chromatographic assay for the anticonvulsant drug ethotoin in plasma has been used to establish a kinetic basis for therapy in eight newly diagnosed epileptic patients. 2 Only a small fraction of ethotoin was excreted unchanged. Elimination curves were only rectilinear below a plasma concentration of 8 mg/l. During constant medication plasma concentrations tended to decrease in the first week. Steady-state plasma levels varied considerably between individuals. For all patients the plasma concentration/dose ratio increased with increasing dose. 3 Most of the results point to dose-dependent elimination kinetics in the therapeutic range and parallel what is known for phenytoin. Control of therapy by measurement of plasma levels of ethotoin is accordingly advocated." @default.
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- W2000505750 date "1975-05-01" @default.
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- W2000505750 title "Dose-dependent kinetics of ethotoin in man" @default.
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- W2000505750 doi "https://doi.org/10.1111/j.1440-1681.1975.tb03024.x" @default.
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