FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000506188> ?p ?o ?g. }

• W2000506188 endingPage "1940" @default.
• W2000506188 startingPage "1935" @default.
• W2000506188 abstract "Dickkopf-1 (DKK1) is a negative regulator of the Wnt/β-catenin signaling pathway, which is expressed in various human cancers. It was hypothesized that DKK1 was oncogenic and involved in invasive growth in non-small cell lung cancer (NSCLC) cells. The present study aimed to investigate whether DKK1 gene expression levels differ among various NSCLC cells. The DKK1 expression pattern was analyzed in various human NSCLC cell lines and tissues. The DKK1 protein and gene expression levels were quantified using immunoblotting, polymerase chain reaction analysis and immunohistochemistry. The majority of the lung cancer cell lines analyzed revealed increased expression levels of DKK1. Furthermore, DKK1 expression was highly transactivated in the majority of these cancer cell lines. Clinical samples were obtained from 98 NSCLC patients for immunohistochemical analysis. Of the 98 samples analyzed, 62 (63.3%) demonstrated positive staining for DKK1, whereas the remaining 36 (37%) exhibited negative staining. However, no immunohistopathological staining was detected in normal tissues. The relative effects of DKK1 were assessed in a high-expression cell line (LTEP-a-2) and a low-expression cell line (95D). The differential expression of genes involved in cell cycle, apoptosis, signaling pathway, invasion and metastasis were evaluated, relative to DKK1 levels. In conclusion, the results of the present study indicated that DKK1 functioned as a key regulator in the progression of NSCLC. The results confirmed the differential expression of DKK1 in NSCLC cells, which may present a potential therapeutic target for cancer prevention." @default.
• W2000506188 created "2016-06-24" @default.
• W2000506188 creator A5021174012 @default.
• W2000506188 creator A5024252338 @default.
• W2000506188 creator A5040765860 @default.
• W2000506188 creator A5090480616 @default.
• W2000506188 date "2015-04-21" @default.
• W2000506188 modified "2023-09-28" @default.
• W2000506188 title "Differential expression of Dickkopf-1 among non-small cell lung cancer cells" @default.
• W2000506188 cites W1522567947 @default.
• W2000506188 cites W1993312546 @default.
• W2000506188 cites W2000159893 @default.
• W2000506188 cites W2001113336 @default.
• W2000506188 cites W2012944782 @default.
• W2000506188 cites W2023407460 @default.
• W2000506188 cites W2030032444 @default.
• W2000506188 cites W2038055986 @default.
• W2000506188 cites W2039758892 @default.
• W2000506188 cites W2053300466 @default.
• W2000506188 cites W2057120263 @default.
• W2000506188 cites W2057199920 @default.
• W2000506188 cites W2060726822 @default.
• W2000506188 cites W2072232539 @default.
• W2000506188 cites W2078979652 @default.
• W2000506188 cites W2087065324 @default.
• W2000506188 cites W2096865440 @default.
• W2000506188 cites W2110577277 @default.
• W2000506188 cites W2119971900 @default.
• W2000506188 cites W2124060121 @default.
• W2000506188 cites W2144715657 @default.
• W2000506188 cites W2320816131 @default.
• W2000506188 cites W2326188967 @default.
• W2000506188 cites W4293247451 @default.
• W2000506188 doi "https://doi.org/10.3892/mmr.2015.3654" @default.
• W2000506188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25901391" @default.
• W2000506188 hasPublicationYear "2015" @default.
• W2000506188 type Work @default.
• W2000506188 sameAs 2000506188 @default.
• W2000506188 citedByCount "13" @default.
• W2000506188 countsByYear W20005061882015 @default.
• W2000506188 countsByYear W20005061882016 @default.
• W2000506188 countsByYear W20005061882017 @default.
• W2000506188 countsByYear W20005061882018 @default.
• W2000506188 countsByYear W20005061882019 @default.
• W2000506188 countsByYear W20005061882020 @default.
• W2000506188 countsByYear W20005061882021 @default.
• W2000506188 crossrefType "journal-article" @default.
• W2000506188 hasAuthorship W2000506188A5021174012 @default.
• W2000506188 hasAuthorship W2000506188A5024252338 @default.
• W2000506188 hasAuthorship W2000506188A5040765860 @default.
• W2000506188 hasAuthorship W2000506188A5090480616 @default.
• W2000506188 hasBestOaLocation W20005061881 @default.
• W2000506188 hasConcept C121608353 @default.
• W2000506188 hasConcept C137620995 @default.
• W2000506188 hasConcept C142724271 @default.
• W2000506188 hasConcept C1491633281 @default.
• W2000506188 hasConcept C190283241 @default.
• W2000506188 hasConcept C203014093 @default.
• W2000506188 hasConcept C204232928 @default.
• W2000506188 hasConcept C2776256026 @default.
• W2000506188 hasConcept C2777491412 @default.
• W2000506188 hasConcept C2779013556 @default.
• W2000506188 hasConcept C2781018059 @default.
• W2000506188 hasConcept C29537977 @default.
• W2000506188 hasConcept C502942594 @default.
• W2000506188 hasConcept C54355233 @default.
• W2000506188 hasConcept C62112901 @default.
• W2000506188 hasConcept C62478195 @default.
• W2000506188 hasConcept C71924100 @default.
• W2000506188 hasConcept C86803240 @default.
• W2000506188 hasConcept C95444343 @default.
• W2000506188 hasConcept C96232424 @default.
• W2000506188 hasConceptScore W2000506188C121608353 @default.
• W2000506188 hasConceptScore W2000506188C137620995 @default.
• W2000506188 hasConceptScore W2000506188C142724271 @default.
• W2000506188 hasConceptScore W2000506188C1491633281 @default.
• W2000506188 hasConceptScore W2000506188C190283241 @default.
• W2000506188 hasConceptScore W2000506188C203014093 @default.
• W2000506188 hasConceptScore W2000506188C204232928 @default.
• W2000506188 hasConceptScore W2000506188C2776256026 @default.
• W2000506188 hasConceptScore W2000506188C2777491412 @default.
• W2000506188 hasConceptScore W2000506188C2779013556 @default.
• W2000506188 hasConceptScore W2000506188C2781018059 @default.
• W2000506188 hasConceptScore W2000506188C29537977 @default.
• W2000506188 hasConceptScore W2000506188C502942594 @default.
• W2000506188 hasConceptScore W2000506188C54355233 @default.
• W2000506188 hasConceptScore W2000506188C62112901 @default.
• W2000506188 hasConceptScore W2000506188C62478195 @default.
• W2000506188 hasConceptScore W2000506188C71924100 @default.
• W2000506188 hasConceptScore W2000506188C86803240 @default.
• W2000506188 hasConceptScore W2000506188C95444343 @default.
• W2000506188 hasConceptScore W2000506188C96232424 @default.
• W2000506188 hasIssue "2" @default.
• W2000506188 hasLocation W20005061881 @default.
• W2000506188 hasLocation W20005061882 @default.
• W2000506188 hasOpenAccess W2000506188 @default.
• W2000506188 hasPrimaryLocation W20005061881 @default.
• W2000506188 hasRelatedWork W2159406762 @default.

• next