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- W2000507917 abstract "To determine whether alteration of PKCα expression would affect the metastatic potential of human melanoma cells, replicate cultures of C8161 cells were treated in vitro with a phosphorothioate antisense oligodeoxynucleotide (ODN) that specifically inhibits PKCα expression (ISIS-3521). Control C8161 cultures were treated with a scrambled sequence ODN, cationic liposomes or were left untreated. Northern blots demonstrated 70% inhibition of PKCα mRNA in ISIS-3521-treated cells compared to controls. Metastasis was suppressed by 75% when ISIS-3521-treated cells were injected intravenously into athymic mice. These results show that PKCα expression is important in the regulation of human melanoma metastasis." @default.
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- W2000507917 date "1998-06-01" @default.
- W2000507917 modified "2023-10-13" @default.
- W2000507917 title "Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-α" @default.
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- W2000507917 doi "https://doi.org/10.1016/s0304-3835(98)00052-4" @default.
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