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- W2000508413 abstract "WE investigated some in vitro pharmacological properties of a novel human dopamine D2-like receptor antagonist, YM-50001 [(R)-5-chloro-4-cyclopropylcar- bonylamino-2-methoxy-N-[l-(3-methoxybenzyl)-3-pyrrolidinyl]benzamide monooxalate]. Receptor binding studies revealed that YM-50001 had a potent affinity for human D4 receptors (Ki = 5.62 nM). YM-50001 displayed weak or negligible affinity for other neurotransmitter receptors including human D2 and D3 receptors. YM-50001 shifted the dopamine response curve on each human D2-like receptor subtype-mediated low-Am GTPase activity to the right. YM-50001 also exhibited good D4 selectivity with respect to D2-like receptor antagonism in the functional assay. These results indicate that YM-50001 is a novel, potent and selective D4 receptor antagonist." @default.
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- W2000508413 date "1996-11-01" @default.
- W2000508413 modified "2023-10-08" @default.
- W2000508413 title "YM-50001" @default.
- W2000508413 doi "https://doi.org/10.1097/00001756-199611040-00028" @default.
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