FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000509706> ?p ?o ?g. }

• W2000509706 endingPage "1423" @default.
• W2000509706 startingPage "1412" @default.
• W2000509706 abstract "A natural retinoid all-trans retinoic acid (ATRA) regulates a variety of important cellular functions via retinoic acid receptor (RAR). ATRA has therapeutically been used against various malignancies including acute promyelocytic leukemia. Recently ATRA has also been recognized to be beneficial against atherosclerotic vascular disorders. However, its effects on angiogenesis remain controversial. We therefore examined ATRA effects on in vitro angiogenesis in terms of capillary-like tube formation using human umbilical vein endothelial cells (HUVECs)/normal human dermal fibroblast (NHDF) coculture. ATRA as well as RAR agonist Am80 significantly induced capillary-like tube formation. The ATRA-induced tube formation was inhibited by coincubation with RAR antagonist LE540/LE135. HUVEC proliferation, but not its migration, was also induced by ATRA. The ATRA-induced tube formation was completely abolished by coincubation with vascular endothelial growth factor (VEGF) neutralizing antibody or with VEGF receptor (VEGFR)-2 (KDR) neutralizing antibody, but not VEGFR-1 (Flt-1) neutralizing antibody. ATRA and Am80 induced VEGF secretion in the coculture as well as VEGF secretion/mRNA expression in NHDFs. Transcription activity of human VEGF gene promoter in NHDFs was stimulated by ATRA, which was augmented by RAR overexpression. ATRA also induced VDGFR-2/KDR mRNA expression in HUVECs. Moreover, ATRA-induced secretion of hepatocyte growth factor as well as angiopoietin-2 in the coculture. Taken together, ATRA may have induced angiogenesis via RAR mainly by stimulation of HUVEC proliferation and enhancement of endogenous VEGF signaling and in part by induction of hepatocyte growth factor and angiopoietin-2 production. Retinoids may therefore be potential candidates for therapeutic angiogenesis against ischemic vascular disorders." @default.
• W2000509706 created "2016-06-24" @default.
• W2000509706 creator A5013252958 @default.
• W2000509706 creator A5016286590 @default.
• W2000509706 creator A5033725334 @default.
• W2000509706 creator A5050198503 @default.
• W2000509706 creator A5056779739 @default.
• W2000509706 creator A5058165376 @default.
• W2000509706 creator A5060303955 @default.
• W2000509706 creator A5066495888 @default.
• W2000509706 creator A5070055930 @default.
• W2000509706 creator A5076321950 @default.
• W2000509706 creator A5087285678 @default.
• W2000509706 creator A5088430785 @default.
• W2000509706 creator A5090136512 @default.
• W2000509706 date "2007-03-01" @default.
• W2000509706 modified "2023-10-03" @default.
• W2000509706 title "All-trans Retinoic Acid Induces in Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling" @default.
• W2000509706 cites W1516603921 @default.
• W2000509706 cites W1537712767 @default.
• W2000509706 cites W1561178184 @default.
• W2000509706 cites W1600721209 @default.
• W2000509706 cites W1750460473 @default.
• W2000509706 cites W1953640231 @default.
• W2000509706 cites W1964946950 @default.
• W2000509706 cites W1967280193 @default.
• W2000509706 cites W1971367730 @default.
• W2000509706 cites W2004880868 @default.
• W2000509706 cites W2010549888 @default.
• W2000509706 cites W2034066397 @default.
• W2000509706 cites W2040183552 @default.
• W2000509706 cites W2040347441 @default.
• W2000509706 cites W2040468663 @default.
• W2000509706 cites W2053392008 @default.
• W2000509706 cites W2064438145 @default.
• W2000509706 cites W2070509236 @default.
• W2000509706 cites W2073992079 @default.
• W2000509706 cites W2076907503 @default.
• W2000509706 cites W2082297364 @default.
• W2000509706 cites W2082954230 @default.
• W2000509706 cites W2090138331 @default.
• W2000509706 cites W2094406330 @default.
• W2000509706 cites W2100025529 @default.
• W2000509706 cites W2100085513 @default.
• W2000509706 cites W2100542906 @default.
• W2000509706 cites W2101663639 @default.
• W2000509706 cites W2110019725 @default.
• W2000509706 cites W2112726396 @default.
• W2000509706 cites W2112911107 @default.
• W2000509706 cites W2113920157 @default.
• W2000509706 cites W2119214811 @default.
• W2000509706 cites W2120895512 @default.
• W2000509706 cites W2129157951 @default.
• W2000509706 cites W2129441135 @default.
• W2000509706 cites W2132855064 @default.
• W2000509706 cites W2135639857 @default.
• W2000509706 cites W2144026946 @default.
• W2000509706 cites W2152927256 @default.
• W2000509706 cites W2271619363 @default.
• W2000509706 cites W2299538019 @default.
• W2000509706 cites W2318774698 @default.
• W2000509706 cites W2325482262 @default.
• W2000509706 cites W2949789122 @default.
• W2000509706 doi "https://doi.org/10.1210/en.2006-0900" @default.
• W2000509706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17170094" @default.
• W2000509706 hasPublicationYear "2007" @default.
• W2000509706 type Work @default.
• W2000509706 sameAs 2000509706 @default.
• W2000509706 citedByCount "95" @default.
• W2000509706 countsByYear W20005097062012 @default.
• W2000509706 countsByYear W20005097062013 @default.
• W2000509706 countsByYear W20005097062014 @default.
• W2000509706 countsByYear W20005097062015 @default.
• W2000509706 countsByYear W20005097062016 @default.
• W2000509706 countsByYear W20005097062017 @default.
• W2000509706 countsByYear W20005097062018 @default.
• W2000509706 countsByYear W20005097062019 @default.
• W2000509706 countsByYear W20005097062020 @default.
• W2000509706 countsByYear W20005097062021 @default.
• W2000509706 countsByYear W20005097062022 @default.
• W2000509706 countsByYear W20005097062023 @default.
• W2000509706 crossrefType "journal-article" @default.
• W2000509706 hasAuthorship W2000509706A5013252958 @default.
• W2000509706 hasAuthorship W2000509706A5016286590 @default.
• W2000509706 hasAuthorship W2000509706A5033725334 @default.
• W2000509706 hasAuthorship W2000509706A5050198503 @default.
• W2000509706 hasAuthorship W2000509706A5056779739 @default.
• W2000509706 hasAuthorship W2000509706A5058165376 @default.
• W2000509706 hasAuthorship W2000509706A5060303955 @default.
• W2000509706 hasAuthorship W2000509706A5066495888 @default.
• W2000509706 hasAuthorship W2000509706A5070055930 @default.
• W2000509706 hasAuthorship W2000509706A5076321950 @default.
• W2000509706 hasAuthorship W2000509706A5087285678 @default.
• W2000509706 hasAuthorship W2000509706A5088430785 @default.
• W2000509706 hasAuthorship W2000509706A5090136512 @default.
• W2000509706 hasBestOaLocation W20005097061 @default.
• W2000509706 hasConcept C120197328 @default.
• W2000509706 hasConcept C126322002 @default.

• next