FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000510976> ?p ?o ?g. }

• W2000510976 endingPage "215" @default.
• W2000510976 startingPage "207" @default.
• W2000510976 abstract "Tissue factor pathway Inhibitor-2 (TFPI-2) is associated with extracellular matrices and plays a major role in cell migration and tumor invasion. In this study, a 4.8-kb human TFPI-2 gene 5'-flanking region was isolated, cloned and sequenced. Promoter region analysis revealed a high GC-rich content without canonical TATA and CAAT boxes but three transcription initiation sites were identified. Moreover, several putative binding sites for transcription factors were identified (MyoD, LYF1, NF-Y, GATA, oct-1, AP-1, Sp1, NF1, NF-kappa B and egr-1). To characterize potential regulatory regions, TFPI-2/luciferase promoter constructs were then transfected in human choriocarcinoma JEG-3 cells. We first showed that the minimal TFPI-2 promoter is located between -166 and -111 from the translation start site. Luciferase activity consistently increased after stimulation of JEG-3 cells by phorbol 12-myristate 13-acetate indicating that NF1, NF-kappa B and egr-1/Sp1 binding sites are crucial in inducible TFPI-2 expression. Moreover, negative regulatory regions included AP-1 binding sites were identified. This study demonstrates that the TFPI-2 gene promoter exhibits typical features of a housekeeping gene." @default.
• W2000510976 created "2016-06-24" @default.
• W2000510976 creator A5018171524 @default.
• W2000510976 creator A5024332177 @default.
• W2000510976 creator A5042814519 @default.
• W2000510976 creator A5049091370 @default.
• W2000510976 creator A5068654519 @default.
• W2000510976 date "2003-02-01" @default.
• W2000510976 modified "2023-09-26" @default.
• W2000510976 title "Characterization and functional analysis of TFPI-2 gene promoter in a human choriocarcinoma cell line" @default.
• W2000510976 cites W186373793 @default.
• W2000510976 cites W1902350137 @default.
• W2000510976 cites W1947449479 @default.
• W2000510976 cites W1978198515 @default.
• W2000510976 cites W1984958828 @default.
• W2000510976 cites W1991481331 @default.
• W2000510976 cites W1995866851 @default.
• W2000510976 cites W2001381510 @default.
• W2000510976 cites W2005065484 @default.
• W2000510976 cites W2024562215 @default.
• W2000510976 cites W2025804135 @default.
• W2000510976 cites W2026740600 @default.
• W2000510976 cites W2026906569 @default.
• W2000510976 cites W2030539074 @default.
• W2000510976 cites W2037257561 @default.
• W2000510976 cites W2046195556 @default.
• W2000510976 cites W2048123277 @default.
• W2000510976 cites W2051904215 @default.
• W2000510976 cites W2053110479 @default.
• W2000510976 cites W2076362095 @default.
• W2000510976 cites W2080786556 @default.
• W2000510976 cites W2094070957 @default.
• W2000510976 cites W2104643487 @default.
• W2000510976 cites W2107218017 @default.
• W2000510976 cites W2142890842 @default.
• W2000510976 cites W2328331914 @default.
• W2000510976 cites W70874736 @default.
• W2000510976 doi "https://doi.org/10.1016/s0049-3848(03)00147-6" @default.
• W2000510976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12757776" @default.
• W2000510976 hasPublicationYear "2003" @default.
• W2000510976 type Work @default.
• W2000510976 sameAs 2000510976 @default.
• W2000510976 citedByCount "29" @default.
• W2000510976 countsByYear W20005109762012 @default.
• W2000510976 countsByYear W20005109762013 @default.
• W2000510976 countsByYear W20005109762014 @default.
• W2000510976 countsByYear W20005109762015 @default.
• W2000510976 countsByYear W20005109762017 @default.
• W2000510976 countsByYear W20005109762018 @default.
• W2000510976 countsByYear W20005109762023 @default.
• W2000510976 crossrefType "journal-article" @default.
• W2000510976 hasAuthorship W2000510976A5018171524 @default.
• W2000510976 hasAuthorship W2000510976A5024332177 @default.
• W2000510976 hasAuthorship W2000510976A5042814519 @default.
• W2000510976 hasAuthorship W2000510976A5049091370 @default.
• W2000510976 hasAuthorship W2000510976A5068654519 @default.
• W2000510976 hasBestOaLocation W20005109764 @default.
• W2000510976 hasConcept C101762097 @default.
• W2000510976 hasConcept C104317684 @default.
• W2000510976 hasConcept C107824862 @default.
• W2000510976 hasConcept C111335760 @default.
• W2000510976 hasConcept C150194340 @default.
• W2000510976 hasConcept C153911025 @default.
• W2000510976 hasConcept C161733203 @default.
• W2000510976 hasConcept C165864922 @default.
• W2000510976 hasConcept C183978625 @default.
• W2000510976 hasConcept C186493320 @default.
• W2000510976 hasConcept C54009773 @default.
• W2000510976 hasConcept C54355233 @default.
• W2000510976 hasConcept C86339819 @default.
• W2000510976 hasConcept C86803240 @default.
• W2000510976 hasConceptScore W2000510976C101762097 @default.
• W2000510976 hasConceptScore W2000510976C104317684 @default.
• W2000510976 hasConceptScore W2000510976C107824862 @default.
• W2000510976 hasConceptScore W2000510976C111335760 @default.
• W2000510976 hasConceptScore W2000510976C150194340 @default.
• W2000510976 hasConceptScore W2000510976C153911025 @default.
• W2000510976 hasConceptScore W2000510976C161733203 @default.
• W2000510976 hasConceptScore W2000510976C165864922 @default.
• W2000510976 hasConceptScore W2000510976C183978625 @default.
• W2000510976 hasConceptScore W2000510976C186493320 @default.
• W2000510976 hasConceptScore W2000510976C54009773 @default.
• W2000510976 hasConceptScore W2000510976C54355233 @default.
• W2000510976 hasConceptScore W2000510976C86339819 @default.
• W2000510976 hasConceptScore W2000510976C86803240 @default.
• W2000510976 hasIssue "4" @default.
• W2000510976 hasLocation W20005109761 @default.
• W2000510976 hasLocation W20005109762 @default.
• W2000510976 hasLocation W20005109763 @default.
• W2000510976 hasLocation W20005109764 @default.
• W2000510976 hasLocation W20005109765 @default.
• W2000510976 hasOpenAccess W2000510976 @default.
• W2000510976 hasPrimaryLocation W20005109761 @default.
• W2000510976 hasRelatedWork W1840763667 @default.
• W2000510976 hasRelatedWork W1968603674 @default.
• W2000510976 hasRelatedWork W2045115548 @default.
• W2000510976 hasRelatedWork W2045652250 @default.
• W2000510976 hasRelatedWork W2082926700 @default.

• next