FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000511084> ?p ?o ?g. }

• W2000511084 endingPage "972" @default.
• W2000511084 startingPage "963" @default.
• W2000511084 abstract "Background Microcystic macular oedema (MMO) of the retinal inner nuclear layer (INL) has been identified in patients with multiple sclerosis (MS) by use of optical coherence tomography (OCT). We aimed to determine whether MMO of the INL, and increased thickness of the INL are associated with disease activity or disability progression. Methods This retrospective study was done at the Johns Hopkins Hospital (Baltimore, MD, USA), between September, 2008, and March, 2012. Patients with MS and healthy controls underwent serial OCT scans and clinical assessments including visual function. OCT scanning, including automated intraretinal layer segmentation, yielded thicknesses of the retinal nerve fibre layer, the ganglion cell layer plus inner plexiform layer, the INL plus outer plexiform layer (the combined thickness of these layers was used as a surrogate measure of INL thickness), and the outer nuclear layer. Patients with MS also underwent annual brain MRI scans. Disability scores were compared with the Wilcoxon rank-sum test. Mixed-effects linear regression was used to compare OCT measures and letter-acuity scores. Logistic regression was used to examine the relations of baseline OCT thicknesses with clinical and radiological parameters. Findings 164 patients with MS and 60 healthy controls were assessed. Mean follow-up was 25·8 months (SD 9·1) for patients with MS and 22·4 months (11·4) for healthy controls. Ten (6%) patients with MS had MMO during at least one study visit; MMO was visible at baseline in four of these patients. Healthy controls did not have MMO. Patients with MS and MMO had higher baseline MS severity scores (median 5·93 [range 2·44–8·91]) than those who did not have MMO at any time during the study (151 patients; 3·81 [0·13–9·47]; p=0·032), although expanded disability status scale (EDSS) scores were not significantly different (5·2 [1·0–6·5] for patients with MS and MMO vs 2·5 [0·0–8·0] for those without MMO; p=0·097). The eyes of patients with MS and MMO (12 eyes) versus those without MMO (302 eyes) had lower letter-acuity scores (100% contrast, p=0·017; 2·5% contrast, p=0·031; 1·25% contrast, p=0·014), and increased INL thicknesses (p=0·003) at baseline. Increased baseline INL thickness in patients with MS was associated with the development of contrast-enhancing lesions (p=0·007), new T2 lesions (p=0·015), EDSS progression (p=0·034), and relapses in patients with relapsing-remitting MS (p=0·008) during the study. MMO was not associated with disease activity during follow-up. Interpretation Increased INL thickness on OCT is associated with disease activity in MS. If this finding is confirmed, INL thickness could be a useful predictor of disease progression in patients with MS. Funding National Multiple Sclerosis Society, National Eye Institute, Braxton Debbie Angela Dillon and Skip Donor Advisor Fund." @default.
• W2000511084 created "2016-06-24" @default.
• W2000511084 creator A5008771598 @default.
• W2000511084 creator A5010289666 @default.
• W2000511084 creator A5012449119 @default.
• W2000511084 creator A5013357095 @default.
• W2000511084 creator A5013633706 @default.
• W2000511084 creator A5040364341 @default.
• W2000511084 creator A5052025260 @default.
• W2000511084 creator A5058205908 @default.
• W2000511084 creator A5059547398 @default.
• W2000511084 creator A5061851273 @default.
• W2000511084 creator A5079550958 @default.
• W2000511084 creator A5080257392 @default.
• W2000511084 creator A5083154754 @default.
• W2000511084 creator A5089030792 @default.
• W2000511084 creator A5091022089 @default.
• W2000511084 date "2012-11-01" @default.
• W2000511084 modified "2023-10-16" @default.
• W2000511084 title "Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study" @default.
• W2000511084 cites W1965604616 @default.
• W2000511084 cites W1970626055 @default.
• W2000511084 cites W1972945861 @default.
• W2000511084 cites W1976987174 @default.
• W2000511084 cites W1977145762 @default.
• W2000511084 cites W1982079826 @default.
• W2000511084 cites W1995433786 @default.
• W2000511084 cites W2000975457 @default.
• W2000511084 cites W2006175679 @default.
• W2000511084 cites W2020537414 @default.
• W2000511084 cites W2026956757 @default.
• W2000511084 cites W2037171954 @default.
• W2000511084 cites W2039500987 @default.
• W2000511084 cites W2042243461 @default.
• W2000511084 cites W2049116186 @default.
• W2000511084 cites W2057911576 @default.
• W2000511084 cites W2109448373 @default.
• W2000511084 cites W2113922996 @default.
• W2000511084 cites W2114525905 @default.
• W2000511084 cites W2122237804 @default.
• W2000511084 cites W2122545833 @default.
• W2000511084 cites W2127294620 @default.
• W2000511084 cites W2129008615 @default.
• W2000511084 cites W2138779588 @default.
• W2000511084 cites W2150727535 @default.
• W2000511084 cites W2151340435 @default.
• W2000511084 cites W2151731343 @default.
• W2000511084 cites W2180705783 @default.
• W2000511084 doi "https://doi.org/10.1016/s1474-4422(12)70213-2" @default.
• W2000511084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3533139" @default.
• W2000511084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23041237" @default.
• W2000511084 hasPublicationYear "2012" @default.
• W2000511084 type Work @default.
• W2000511084 sameAs 2000511084 @default.
• W2000511084 citedByCount "250" @default.
• W2000511084 countsByYear W20005110842012 @default.
• W2000511084 countsByYear W20005110842013 @default.
• W2000511084 countsByYear W20005110842014 @default.
• W2000511084 countsByYear W20005110842015 @default.
• W2000511084 countsByYear W20005110842016 @default.
• W2000511084 countsByYear W20005110842017 @default.
• W2000511084 countsByYear W20005110842018 @default.
• W2000511084 countsByYear W20005110842019 @default.
• W2000511084 countsByYear W20005110842020 @default.
• W2000511084 countsByYear W20005110842021 @default.
• W2000511084 countsByYear W20005110842022 @default.
• W2000511084 countsByYear W20005110842023 @default.
• W2000511084 crossrefType "journal-article" @default.
• W2000511084 hasAuthorship W2000511084A5008771598 @default.
• W2000511084 hasAuthorship W2000511084A5010289666 @default.
• W2000511084 hasAuthorship W2000511084A5012449119 @default.
• W2000511084 hasAuthorship W2000511084A5013357095 @default.
• W2000511084 hasAuthorship W2000511084A5013633706 @default.
• W2000511084 hasAuthorship W2000511084A5040364341 @default.
• W2000511084 hasAuthorship W2000511084A5052025260 @default.
• W2000511084 hasAuthorship W2000511084A5058205908 @default.
• W2000511084 hasAuthorship W2000511084A5059547398 @default.
• W2000511084 hasAuthorship W2000511084A5061851273 @default.
• W2000511084 hasAuthorship W2000511084A5079550958 @default.
• W2000511084 hasAuthorship W2000511084A5080257392 @default.
• W2000511084 hasAuthorship W2000511084A5083154754 @default.
• W2000511084 hasAuthorship W2000511084A5089030792 @default.
• W2000511084 hasAuthorship W2000511084A5091022089 @default.
• W2000511084 hasBestOaLocation W20005110842 @default.
• W2000511084 hasConcept C118487528 @default.
• W2000511084 hasConcept C118552586 @default.
• W2000511084 hasConcept C141071460 @default.
• W2000511084 hasConcept C167135981 @default.
• W2000511084 hasConcept C2776572573 @default.
• W2000511084 hasConcept C2777506830 @default.
• W2000511084 hasConcept C2777585161 @default.
• W2000511084 hasConcept C2778231335 @default.
• W2000511084 hasConcept C2778257484 @default.
• W2000511084 hasConcept C2778818243 @default.
• W2000511084 hasConcept C2780188069 @default.
• W2000511084 hasConcept C2780592520 @default.
• W2000511084 hasConcept C2780640218 @default.
• W2000511084 hasConcept C2780827179 @default.

• next