Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000511578> ?p ?o ?g. }
- W2000511578 endingPage "e49952" @default.
- W2000511578 startingPage "e49952" @default.
- W2000511578 abstract "Chickens lack the retinoic acid-inducible gene I (RIG-I) and sense avian influenza virus (AIV) infections by means of the melanoma differentiation-associated gene 5 product (chMDA5). Plasmid-driven expression of the N-terminal half of chMDA5 containing the caspase activation and recruitment domains [chMDA5(1-483)] triggers interferon-β responses in chicken cells. We hypothesized that mimicking virus infection by chMDA5(1-483) expression may enhance vaccine-induced adaptive immunity. In order to test this, the potential genetic adjuvant properties of chMDA5(1-483) were evaluated in vivo in combination with a suboptimal quantity of a plasmid DNA vaccine expressing haemagglutinin (HA) of H5N1 AIV. Co-administration of the HA plasmid with plasmid DNA for chMDA5(1-483) expression resulted in approximately 10-fold higher HA-specific antibody responses than injection of the HA plasmid mixed with empty vector DNA as control. Accordingly, compared with HA DNA vaccination alone, the chMDA5(1-483)-adjuvanted HA DNA vaccine mediated enhanced protection against a lethal H5N1 challenge infection in chickens, with reduced clinical signs and cloacal virus shedding. These data demonstrate that innate immune activation by expression of signaling domains of RIG-I-like receptors can be exploited to enhance vaccine efficacy." @default.
- W2000511578 created "2016-06-24" @default.
- W2000511578 creator A5001782263 @default.
- W2000511578 creator A5020620315 @default.
- W2000511578 creator A5074927575 @default.
- W2000511578 date "2012-12-05" @default.
- W2000511578 modified "2023-10-06" @default.
- W2000511578 title "MDA5 Can Be Exploited as Efficacious Genetic Adjuvant for DNA Vaccination against Lethal H5N1 Influenza Virus Infection in Chickens" @default.
- W2000511578 cites W1518989519 @default.
- W2000511578 cites W1573590923 @default.
- W2000511578 cites W1583708762 @default.
- W2000511578 cites W161788270 @default.
- W2000511578 cites W1963790908 @default.
- W2000511578 cites W1974546926 @default.
- W2000511578 cites W1975437350 @default.
- W2000511578 cites W1979838502 @default.
- W2000511578 cites W1990166356 @default.
- W2000511578 cites W1994566041 @default.
- W2000511578 cites W1998206819 @default.
- W2000511578 cites W1999329117 @default.
- W2000511578 cites W2003517691 @default.
- W2000511578 cites W2005530726 @default.
- W2000511578 cites W2008735853 @default.
- W2000511578 cites W2018828712 @default.
- W2000511578 cites W2022180444 @default.
- W2000511578 cites W2031175131 @default.
- W2000511578 cites W2032278339 @default.
- W2000511578 cites W2034219960 @default.
- W2000511578 cites W2035376519 @default.
- W2000511578 cites W2036525828 @default.
- W2000511578 cites W2037502650 @default.
- W2000511578 cites W2037709417 @default.
- W2000511578 cites W2042272397 @default.
- W2000511578 cites W2045465609 @default.
- W2000511578 cites W2053127276 @default.
- W2000511578 cites W2053429123 @default.
- W2000511578 cites W2061327148 @default.
- W2000511578 cites W2082580360 @default.
- W2000511578 cites W2089903482 @default.
- W2000511578 cites W2091660088 @default.
- W2000511578 cites W2092067482 @default.
- W2000511578 cites W2093579074 @default.
- W2000511578 cites W2094175565 @default.
- W2000511578 cites W2094977314 @default.
- W2000511578 cites W2096729904 @default.
- W2000511578 cites W2102554711 @default.
- W2000511578 cites W2107513655 @default.
- W2000511578 cites W2113884542 @default.
- W2000511578 cites W2115735742 @default.
- W2000511578 cites W2117212538 @default.
- W2000511578 cites W2119510581 @default.
- W2000511578 cites W2120483717 @default.
- W2000511578 cites W2124284032 @default.
- W2000511578 cites W2126982616 @default.
- W2000511578 cites W2128025490 @default.
- W2000511578 cites W2137303998 @default.
- W2000511578 cites W2141137217 @default.
- W2000511578 cites W2144331816 @default.
- W2000511578 cites W2144887013 @default.
- W2000511578 cites W2149222043 @default.
- W2000511578 cites W2150324671 @default.
- W2000511578 cites W2150387978 @default.
- W2000511578 cites W2164151960 @default.
- W2000511578 cites W2171475287 @default.
- W2000511578 cites W2313729713 @default.
- W2000511578 cites W2470298560 @default.
- W2000511578 cites W277882519 @default.
- W2000511578 doi "https://doi.org/10.1371/journal.pone.0049952" @default.
- W2000511578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3515599" @default.
- W2000511578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23227156" @default.
- W2000511578 hasPublicationYear "2012" @default.
- W2000511578 type Work @default.
- W2000511578 sameAs 2000511578 @default.
- W2000511578 citedByCount "34" @default.
- W2000511578 countsByYear W20005115782013 @default.
- W2000511578 countsByYear W20005115782014 @default.
- W2000511578 countsByYear W20005115782015 @default.
- W2000511578 countsByYear W20005115782016 @default.
- W2000511578 countsByYear W20005115782017 @default.
- W2000511578 countsByYear W20005115782018 @default.
- W2000511578 countsByYear W20005115782019 @default.
- W2000511578 countsByYear W20005115782020 @default.
- W2000511578 countsByYear W20005115782021 @default.
- W2000511578 countsByYear W20005115782022 @default.
- W2000511578 crossrefType "journal-article" @default.
- W2000511578 hasAuthorship W2000511578A5001782263 @default.
- W2000511578 hasAuthorship W2000511578A5020620315 @default.
- W2000511578 hasAuthorship W2000511578A5074927575 @default.
- W2000511578 hasBestOaLocation W20005115781 @default.
- W2000511578 hasConcept C104317684 @default.
- W2000511578 hasConcept C12914427 @default.
- W2000511578 hasConcept C136449434 @default.
- W2000511578 hasConcept C159047783 @default.
- W2000511578 hasConcept C167508917 @default.
- W2000511578 hasConcept C203014093 @default.
- W2000511578 hasConcept C22070199 @default.
- W2000511578 hasConcept C22744801 @default.
- W2000511578 hasConcept C2522874641 @default.