FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000511694> ?p ?o ?g. }

• W2000511694 endingPage "1536" @default.
• W2000511694 startingPage "1529" @default.
• W2000511694 abstract "BACKGROUND Lysophosphatidic acid (LPA) induced a dose-dependent increase of cancer cell invasion by promoting Rho/Rho-associated kinase signaling. Prenylation of Rho is essential for regulating cell growth, motility, and invasion. Geranylgeranylacetone (GGA), an isoprenoid compound, is used clinically as an antiulcer drug. Recent findings suggested that GGA might inhibit the small GTPase activation by suppressing prenylation. The authors hypothesized that the anticancer effects of GGA result from the inhibition of Rho activation. METHODS The authors examined the effect of GGA using an in vitro invasion assay in human ovarian carcinoma cells, and analyzed the mechanism of the GGA effect on Rho activation, stress fiber formation and focal adhesion assembly, which are essential processes for cell invasion. RESULTS The induction of ovarian carcinoma cell invasion by LPA was inhibited by the addition of GGA in a dose-dependent manner. Treatment of cancer cells with GGA resulted in inactivation of Rho, changes in cell morphology, loss of stress fiber formation and focal adhesion assembly, and the suppression of tyrosine phosphorylation of focal adhesion proteins. The effect of GGA on cancer cells was partially prevented by the addition of geranylgeraniol, which is an intermediate of geranylgeranyl pyrophosphate and compensates geranylgeranylation of Rho. CONCLUSIONS The inhibition of LPA-induced invasion by GGA was, at least in part, derived from suppressed Rho activation by preventing geranylgeranylation. Cancer 2005. © 2005 American Cancer Society." @default.
• W2000511694 created "2016-06-24" @default.
• W2000511694 creator A5006897018 @default.
• W2000511694 creator A5008483463 @default.
• W2000511694 creator A5011233448 @default.
• W2000511694 creator A5019463160 @default.
• W2000511694 creator A5022629155 @default.
• W2000511694 creator A5034831994 @default.
• W2000511694 creator A5040789531 @default.
• W2000511694 creator A5046721669 @default.
• W2000511694 date "2005-02-28" @default.
• W2000511694 modified "2023-10-16" @default.
• W2000511694 title "Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro" @default.
• W2000511694 cites W1594278877 @default.
• W2000511694 cites W1978156529 @default.
• W2000511694 cites W1995249229 @default.
• W2000511694 cites W2004118458 @default.
• W2000511694 cites W2011910484 @default.
• W2000511694 cites W2022014446 @default.
• W2000511694 cites W2042717830 @default.
• W2000511694 cites W2043403795 @default.
• W2000511694 cites W2047494612 @default.
• W2000511694 cites W2048202432 @default.
• W2000511694 cites W2066367871 @default.
• W2000511694 cites W2077241256 @default.
• W2000511694 cites W2083982105 @default.
• W2000511694 cites W2108730684 @default.
• W2000511694 cites W2117519868 @default.
• W2000511694 cites W2130172628 @default.
• W2000511694 cites W2143797732 @default.
• W2000511694 cites W2150102283 @default.
• W2000511694 cites W2150757489 @default.
• W2000511694 cites W2150838353 @default.
• W2000511694 cites W2153685046 @default.
• W2000511694 cites W2168727673 @default.
• W2000511694 cites W2169667471 @default.
• W2000511694 cites W2184141090 @default.
• W2000511694 cites W2375169070 @default.
• W2000511694 cites W4242024627 @default.
• W2000511694 doi "https://doi.org/10.1002/cncr.20941" @default.
• W2000511694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15739201" @default.
• W2000511694 hasPublicationYear "2005" @default.
• W2000511694 type Work @default.
• W2000511694 sameAs 2000511694 @default.
• W2000511694 citedByCount "17" @default.
• W2000511694 countsByYear W20005116942013 @default.
• W2000511694 countsByYear W20005116942014 @default.
• W2000511694 countsByYear W20005116942016 @default.
• W2000511694 countsByYear W20005116942017 @default.
• W2000511694 countsByYear W20005116942019 @default.
• W2000511694 countsByYear W20005116942022 @default.
• W2000511694 crossrefType "journal-article" @default.
• W2000511694 hasAuthorship W2000511694A5006897018 @default.
• W2000511694 hasAuthorship W2000511694A5008483463 @default.
• W2000511694 hasAuthorship W2000511694A5011233448 @default.
• W2000511694 hasAuthorship W2000511694A5019463160 @default.
• W2000511694 hasAuthorship W2000511694A5022629155 @default.
• W2000511694 hasAuthorship W2000511694A5034831994 @default.
• W2000511694 hasAuthorship W2000511694A5040789531 @default.
• W2000511694 hasAuthorship W2000511694A5046721669 @default.
• W2000511694 hasBestOaLocation W20005116941 @default.
• W2000511694 hasConcept C121608353 @default.
• W2000511694 hasConcept C126322002 @default.
• W2000511694 hasConcept C1491633281 @default.
• W2000511694 hasConcept C151166631 @default.
• W2000511694 hasConcept C170493617 @default.
• W2000511694 hasConcept C181199279 @default.
• W2000511694 hasConcept C23167141 @default.
• W2000511694 hasConcept C2776661833 @default.
• W2000511694 hasConcept C2778359262 @default.
• W2000511694 hasConcept C2779247237 @default.
• W2000511694 hasConcept C2781099445 @default.
• W2000511694 hasConcept C502942594 @default.
• W2000511694 hasConcept C55493867 @default.
• W2000511694 hasConcept C57790582 @default.
• W2000511694 hasConcept C58207958 @default.
• W2000511694 hasConcept C62478195 @default.
• W2000511694 hasConcept C71924100 @default.
• W2000511694 hasConcept C85789140 @default.
• W2000511694 hasConcept C86803240 @default.
• W2000511694 hasConcept C95444343 @default.
• W2000511694 hasConcept C96232424 @default.
• W2000511694 hasConceptScore W2000511694C121608353 @default.
• W2000511694 hasConceptScore W2000511694C126322002 @default.
• W2000511694 hasConceptScore W2000511694C1491633281 @default.
• W2000511694 hasConceptScore W2000511694C151166631 @default.
• W2000511694 hasConceptScore W2000511694C170493617 @default.
• W2000511694 hasConceptScore W2000511694C181199279 @default.
• W2000511694 hasConceptScore W2000511694C23167141 @default.
• W2000511694 hasConceptScore W2000511694C2776661833 @default.
• W2000511694 hasConceptScore W2000511694C2778359262 @default.
• W2000511694 hasConceptScore W2000511694C2779247237 @default.
• W2000511694 hasConceptScore W2000511694C2781099445 @default.
• W2000511694 hasConceptScore W2000511694C502942594 @default.
• W2000511694 hasConceptScore W2000511694C55493867 @default.
• W2000511694 hasConceptScore W2000511694C57790582 @default.
• W2000511694 hasConceptScore W2000511694C58207958 @default.
• W2000511694 hasConceptScore W2000511694C62478195 @default.

• next