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- W2000512310 abstract "The thyroid gland and its hormones have been reported to influence reproduction and metabolism in a positive manner. However, research to date provides strong evidence for a reciprocal relationship between the immune system and hormones of the hypothalamus-pituitary-thyroid axis. The present study has been taken to elucidate the effect of <i>L</i>-thyroxin (T<sub>4</sub>) on immune parameters such as total leukocyte count, percent lymphocyte count, blastogenic response and percent stimulation ratio of thymocytes and splenocytes of a seasonally breeding rodent, <i>Funambulus pennanti,</i> during its reproductively inactive phase when peripheral T<sub>4</sub> is low. Treatment with <i>L</i>-thyroxin at a near-physiological dose of 35 µg/100 g body weight during evening hours showed a significant elevation of all immune parameters. However, combined treatment of <i>L</i>-thyroxin and melatonin (25 µg/100 g body weight) had no additive effect. On the other hand, in vitro supplementation of T<sub>4</sub> (10<sup>–6</sup> <i>M</i>) either alone or in combination with melatonin (0.5 µ<i>M</i>) did not induce any significant change on thymocyte and splenocyte proliferation. Therefore, a trade-off effect of <i>L</i>-thyroxin and melatonin on the immune system (T- and B-cell differentiation) is suggested for this rodent." @default.
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- W2000512310 date "2005-01-01" @default.
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- W2000512310 title "Trade-Off between <i>L</i>-Thyroxin and Melatonin in Immune Regulation of the Indian Palm Squirrel, <i>Funambulus pennanti </i>during the Reproductively Inactive Phase" @default.
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- W2000512310 doi "https://doi.org/10.1159/000091034" @default.
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