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• W2000513450 abstract "Src homology 3 (SH3) domains are small modules that are thought to fold via a two-state mechanism, without the accumulation of significant populations of intermediate states. Relaxation dispersion NMR studies of the folding of G48V and G48M mutants of the Fyn SH3 domain have established that, at least for these modules, folding proceeds through the formation of a transient on-pathway intermediate with an equilibrium population of 1−2% that can be readily detected [Korzhnev, D. M., et al. (2004) Nature 430, 586−590]. To investigate the generality of this result, we present an 15N relaxation dispersion NMR study of a pair of additional SH3 domains, including a G48V mutant of a stabilized Abp1p SH3 domain that shares 36% sequence identity with the Fyn SH3 module, and a A39V/N53P/V55L mutant Fyn SH3 domain. A transient folding intermediate is detected for both of the proteins studied here, and the dispersion data are well fit to a folding model of the form F ↔ I ↔ U, where F, I, and U correspond to folded, intermediate, and unfolded states, respectively. The temperature dependencies of the folding/unfolding rate constants were obtained so that the thermodynamic properties of each of F, I, and U could be established. The detection of I states in folding pathways of all SH3 domains examined to date via relaxation dispersion NMR spectroscopy indicates that such intermediates may well be a conserved feature in the folding of such domains in general but that their transient nature along with their low population makes detection difficult using more well-established approaches to the study of folding." @default.
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• W2000513450 date "2006-08-01" @default.
• W2000513450 modified "2023-10-14" @default.
• W2000513450 title "Abp1p and Fyn SH3 Domains Fold through Similar Low-Populated Intermediate States" @default.
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• W2000513450 doi "https://doi.org/10.1021/bi0611560" @default.
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