FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000514484> ?p ?o ?g. }

• W2000514484 endingPage "1276" @default.
• W2000514484 startingPage "1267" @default.
• W2000514484 abstract "ABCB1 is a transmembrane transporter that is expressed in excretory organs (kidneys and liver), in intestine mucosa and on the blood-brain barrier. Because of the particular distribution of the protein, the activity of ABCB1 may significantly affect drug pharmacokinetics during absorption and distribution. Of note, several SNPs of ABCB1 are known and many of them affect transporter activity and/or expression. In this view, changes in the pharmacokinetics of drugs that are ABCB1 substrates could be clinically relevant and the evaluation of ABCB1 SNPs should deserve particular attention. Therefore, the aim of the present study was to investigate the possible association between ABCB1 polymorphisms and clozapine plasma levels in psychotic patients.c.1236C>T (exon 12), c.2677G>T (exon 21) and c.3435C>T (exon 26) SNPs of ABCB1 were evaluated by PCR techniques, while plasma levels of clozapine and norclozapine were measured by HPLC in 40 men (aged, 47.6 +/- 16.6 years, median: 42 years) and 20 women (aged 40.7 +/- 11.4 years, median: 38 years) 1 month after the start of clozapine administration.A total of three SNPs were in Hardy-Weinberg equilibrium, with a calculated frequency of the wild-type alleles of 0.54, 0.55 and 0.45 for SNPs on exons 12, 21 and 26, respectively. Patients with c.3435CC or c.2677GG genotypes had significantly lower dose-normalized clozapine levels than those who were heterozygous or TT carriers. More interestingly, c.3435CC patients (15 subjects) needed significantly higher daily doses of clozapine (246 +/- 142 mg/day) compared with the remaining 24 CT and 21 TT patients (140 +/- 90 mg/day) in order to achieve the same clinical benefit.c.3435CC patients require higher clozapine doses to achieve the same plasma concentrations as CT or TT patients, and ABCB1 genotyping should be considered as a novel strategy that should improve drug use." @default.
• W2000514484 created "2016-06-24" @default.
• W2000514484 creator A5000449328 @default.
• W2000514484 creator A5003913815 @default.
• W2000514484 creator A5021319541 @default.
• W2000514484 creator A5041773083 @default.
• W2000514484 creator A5057972536 @default.
• W2000514484 creator A5061195758 @default.
• W2000514484 creator A5077498316 @default.
• W2000514484 creator A5083693387 @default.
• W2000514484 creator A5084400647 @default.
• W2000514484 creator A5086314215 @default.
• W2000514484 date "2009-08-01" @default.
• W2000514484 modified "2023-10-17" @default.
• W2000514484 title "<i>ABCB1</i> polymorphisms are associated with clozapine plasma levels in psychotic patients" @default.
• W2000514484 cites W10300892 @default.
• W2000514484 cites W123422070 @default.
• W2000514484 cites W1974669224 @default.
• W2000514484 cites W1975261946 @default.
• W2000514484 cites W1984170705 @default.
• W2000514484 cites W1988672159 @default.
• W2000514484 cites W1998205876 @default.
• W2000514484 cites W2013970121 @default.
• W2000514484 cites W2019391282 @default.
• W2000514484 cites W2021759214 @default.
• W2000514484 cites W2022470615 @default.
• W2000514484 cites W2023667709 @default.
• W2000514484 cites W2029351291 @default.
• W2000514484 cites W2031082289 @default.
• W2000514484 cites W2037621239 @default.
• W2000514484 cites W2038469872 @default.
• W2000514484 cites W2041397333 @default.
• W2000514484 cites W2043711370 @default.
• W2000514484 cites W2044429819 @default.
• W2000514484 cites W2046948383 @default.
• W2000514484 cites W2054458932 @default.
• W2000514484 cites W2061376955 @default.
• W2000514484 cites W2063288921 @default.
• W2000514484 cites W2066919313 @default.
• W2000514484 cites W2068285828 @default.
• W2000514484 cites W2078671723 @default.
• W2000514484 cites W2080185803 @default.
• W2000514484 cites W2081213990 @default.
• W2000514484 cites W2082515392 @default.
• W2000514484 cites W2085360366 @default.
• W2000514484 cites W2089234769 @default.
• W2000514484 cites W2093203053 @default.
• W2000514484 cites W2096739998 @default.
• W2000514484 cites W2106365121 @default.
• W2000514484 cites W2106764317 @default.
• W2000514484 cites W2108141803 @default.
• W2000514484 cites W2110755408 @default.
• W2000514484 cites W2125748363 @default.
• W2000514484 cites W2156764845 @default.
• W2000514484 cites W2161371959 @default.
• W2000514484 cites W2326963943 @default.
• W2000514484 cites W4235607015 @default.
• W2000514484 doi "https://doi.org/10.2217/pgs.09.51" @default.
• W2000514484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19663671" @default.
• W2000514484 hasPublicationYear "2009" @default.
• W2000514484 type Work @default.
• W2000514484 sameAs 2000514484 @default.
• W2000514484 citedByCount "53" @default.
• W2000514484 countsByYear W20005144842012 @default.
• W2000514484 countsByYear W20005144842013 @default.
• W2000514484 countsByYear W20005144842014 @default.
• W2000514484 countsByYear W20005144842015 @default.
• W2000514484 countsByYear W20005144842016 @default.
• W2000514484 countsByYear W20005144842017 @default.
• W2000514484 countsByYear W20005144842018 @default.
• W2000514484 countsByYear W20005144842019 @default.
• W2000514484 countsByYear W20005144842020 @default.
• W2000514484 countsByYear W20005144842021 @default.
• W2000514484 countsByYear W20005144842022 @default.
• W2000514484 countsByYear W20005144842023 @default.
• W2000514484 crossrefType "journal-article" @default.
• W2000514484 hasAuthorship W2000514484A5000449328 @default.
• W2000514484 hasAuthorship W2000514484A5003913815 @default.
• W2000514484 hasAuthorship W2000514484A5021319541 @default.
• W2000514484 hasAuthorship W2000514484A5041773083 @default.
• W2000514484 hasAuthorship W2000514484A5057972536 @default.
• W2000514484 hasAuthorship W2000514484A5061195758 @default.
• W2000514484 hasAuthorship W2000514484A5077498316 @default.
• W2000514484 hasAuthorship W2000514484A5083693387 @default.
• W2000514484 hasAuthorship W2000514484A5084400647 @default.
• W2000514484 hasAuthorship W2000514484A5086314215 @default.
• W2000514484 hasConcept C104317684 @default.
• W2000514484 hasConcept C112705442 @default.
• W2000514484 hasConcept C118552586 @default.
• W2000514484 hasConcept C126322002 @default.
• W2000514484 hasConcept C135763542 @default.
• W2000514484 hasConcept C153209595 @default.
• W2000514484 hasConcept C180754005 @default.
• W2000514484 hasConcept C2776412080 @default.
• W2000514484 hasConcept C2776598434 @default.
• W2000514484 hasConcept C2780864610 @default.
• W2000514484 hasConcept C36823959 @default.
• W2000514484 hasConcept C54355233 @default.

• next