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- W2000514635 abstract "In neonates with single ventricle congenital heart disease, several clinical findings of neonates such as systemic outflow obstruction and ventricular systolic dysfunction are known risk factors for adverse outcomes. The objective of this study was to determine if the antenatal ultrasound findings and cord blood biomarkers for heart failure can predict neonatal mortality in single ventricle congenital heart disease. A total of 44 cases of single ventricle congenital heart disease were enrolled. The presence of antenatal ultrasound findings suggesting systemic outflow obstruction (ascending aorta < 2.5 percentile) or ventricular dysfunction (the presence of cardiomegaly or hydrops) were evaluated, and the total number of abnormal findings was converted to a numeric score, which was named as “cardiac profile score”. In addition, N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and cardiac troponin T (cTnT) was measured in cord blood which was taken at the time of delivery. The rate of neonatal mortality (within 28 days after birth) was 27% (12/44). The antenatal ultrasound findings of systemic outflow obstruction or ventricular dysfunction were detected more frequently and the cord blood concentrations of NT pro-BNP and cTnT were elevated in cases who are destined to neonatal death. The presence of either abnormal ultrasound findings (cardiac profile score ≥ 2) or elevated concentrations of NT pro-BNP or cTnT was associated with the risk of neonatal death (neonatal death risk: 6% in cases without these finding vs. 41% in cases with at least one of these findings, p < 0.05). The antenatal ultrasound findings and cord blood biomarkers for heart failure can predict neonatal death in single ventricle congenital heart disease. OC02.05: Table 1." @default.
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- W2000514635 date "2014-09-01" @default.
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- W2000514635 title "OC02.05: Antenatal prediction of neonatal death in single ventricle congenital heart disease" @default.
- W2000514635 doi "https://doi.org/10.1002/uog.13473" @default.
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