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- W2000516280 abstract "Clones were derived from highly purified human CD4-8- lymphocytes from three different donors and maintained in the presence of interleukin 2 and phytohaemagglutinin. Considerable variation was noted between donors in the phenotype and T-cell receptor (TCR) γ gene rearrangements of CD4-8- -derived clones. In one donor, most clones remained CD4-8- and all were CD3+WT31- and therefore expressed γ/δ heterodimers. TCR γ gene rearrangements almost all involved Cγ1. In contrast, most clones from a second donor were CD3+WT31-, and therefore expressed α/β heterodimers, and many were positive for CD4 or CD8. Most clones from a third donor were CD3+ WT31- with a high proportion of TCRγ gene rearrangements involving Cγ2. The Vγ9JP rearrangement was exclusively confined to CD3+WT31- clones and was present in the majority of clones. Almost all CD3+WT31- clones showed TCR β as well as γ gene rearrangements. Most CD3+WT31- clones with at least one chromosome rearranged to Cγ1 exhibited high non-major histocompatibility complex (MHC)-restricted cytotoxic activity, while most of those with two Cγ2 rearrangements, and therefore expressing a non-disulphide-linked γ/δ heterodimer, had low activity. Preincubation of effector cells with anti-CD3 strongly inhibited the cytotoxicity of CD3+WT31- clones while that of CD3+WT31- clones was enhanced. This implicates the CD3-γ/δ complex in target cell recognition by cytotoxic γ/δ-bearing T-cell clones. The results show that there is heterogeneity between donors in the relative proportions of CD4-8- -derived clones expressing α/β heterodimers and the different forms of the γ/δ heterodimer." @default.
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- W2000516280 date "1989-06-01" @default.
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- W2000516280 title "Human CD4-8- -Derived Clones Phenotypic and Functional Characteristics and Variation between Donors in Patterns of T-Cell Receptor y Gene Rearrangements" @default.
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- W2000516280 doi "https://doi.org/10.1111/j.1365-3083.1989.tb01174.x" @default.
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