FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000517603> ?p ?o ?g. }

• W2000517603 endingPage "376" @default.
• W2000517603 startingPage "367" @default.
• W2000517603 abstract "Translesion synthesis (TLS), the process by which DNA polymerases replicate through DNA lesions, is the source of most DNA damage-induced mutations. Sometimes TLS is carried out by replicative polymerases that have evolved to synthesize DNA on non-damaged templates. Most of the time, however, TLS is carried out by specialized translesion polymerases that have evolved to synthesize DNA on damaged templates. TLS requires the mono-ubiquitylation of the replication accessory factor proliferating cell nuclear antigen (PCNA). PCNA and ubiquitin-modified PCNA (UbPCNA) stimulate TLS by replicative and translesion polymerases. Two mutant forms of PCNA, one with an E113G substitution and one with a G178S substitution, support normal cell growth but inhibit TLS thereby reducing mutagenesis in yeast. A re-examination of the structures of both mutant PCNA proteins revealed substantial disruptions of the subunit interface that forms the PCNA trimer. Both mutant proteins have reduced trimer stability with the G178S substitution causing a more severe defect. The mutant forms of PCNA and UbPCNA do not stimulate TLS of an abasic site by either replicative Pol δ or translesion Pol η. Normal replication by Pol η was also impacted, but normal replication by Pol δ was much less affected. These findings support a model in which reduced trimer stability causes these mutant PCNA proteins to occasionally undergo conformational changes that compromise their ability to stimulate TLS by both replicative and translesion polymerases." @default.
• W2000517603 created "2016-06-24" @default.
• W2000517603 creator A5069812407 @default.
• W2000517603 creator A5079313612 @default.
• W2000517603 date "2013-05-01" @default.
• W2000517603 modified "2023-09-23" @default.
• W2000517603 title "PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ" @default.
• W2000517603 cites W1515096181 @default.
• W2000517603 cites W1522788044 @default.
• W2000517603 cites W1973245118 @default.
• W2000517603 cites W1973502710 @default.
• W2000517603 cites W1976279799 @default.
• W2000517603 cites W1980745500 @default.
• W2000517603 cites W1982479568 @default.
• W2000517603 cites W1991298183 @default.
• W2000517603 cites W2000558730 @default.
• W2000517603 cites W2000707153 @default.
• W2000517603 cites W2000858063 @default.
• W2000517603 cites W2001209925 @default.
• W2000517603 cites W2003506331 @default.
• W2000517603 cites W2003928652 @default.
• W2000517603 cites W2011338138 @default.
• W2000517603 cites W2013578844 @default.
• W2000517603 cites W2016499597 @default.
• W2000517603 cites W2020866179 @default.
• W2000517603 cites W2021508107 @default.
• W2000517603 cites W2022265644 @default.
• W2000517603 cites W2029981947 @default.
• W2000517603 cites W2035509256 @default.
• W2000517603 cites W2046928699 @default.
• W2000517603 cites W2048855825 @default.
• W2000517603 cites W2053213954 @default.
• W2000517603 cites W2055869110 @default.
• W2000517603 cites W2060262536 @default.
• W2000517603 cites W2063240589 @default.
• W2000517603 cites W2063280340 @default.
• W2000517603 cites W2066480954 @default.
• W2000517603 cites W2067786302 @default.
• W2000517603 cites W2072747624 @default.
• W2000517603 cites W2079691419 @default.
• W2000517603 cites W2088085545 @default.
• W2000517603 cites W2089594949 @default.
• W2000517603 cites W2108641199 @default.
• W2000517603 cites W2114243500 @default.
• W2000517603 cites W2117692326 @default.
• W2000517603 cites W2119301405 @default.
• W2000517603 cites W2124631694 @default.
• W2000517603 cites W2130937328 @default.
• W2000517603 cites W2133800721 @default.
• W2000517603 cites W2139137226 @default.
• W2000517603 cites W2143064529 @default.
• W2000517603 cites W2146128933 @default.
• W2000517603 cites W2167668429 @default.
• W2000517603 cites W2169950973 @default.
• W2000517603 cites W2172128353 @default.
• W2000517603 cites W2188667892 @default.
• W2000517603 doi "https://doi.org/10.1016/j.dnarep.2013.02.007" @default.
• W2000517603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3636165" @default.
• W2000517603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23506842" @default.
• W2000517603 hasPublicationYear "2013" @default.
• W2000517603 type Work @default.
• W2000517603 sameAs 2000517603 @default.
• W2000517603 citedByCount "30" @default.
• W2000517603 countsByYear W20005176032014 @default.
• W2000517603 countsByYear W20005176032015 @default.
• W2000517603 countsByYear W20005176032016 @default.
• W2000517603 countsByYear W20005176032017 @default.
• W2000517603 countsByYear W20005176032018 @default.
• W2000517603 countsByYear W20005176032019 @default.
• W2000517603 countsByYear W20005176032021 @default.
• W2000517603 countsByYear W20005176032022 @default.
• W2000517603 countsByYear W20005176032023 @default.
• W2000517603 crossrefType "journal-article" @default.
• W2000517603 hasAuthorship W2000517603A5069812407 @default.
• W2000517603 hasAuthorship W2000517603A5079313612 @default.
• W2000517603 hasBestOaLocation W20005176032 @default.
• W2000517603 hasConcept C104317684 @default.
• W2000517603 hasConcept C113271649 @default.
• W2000517603 hasConcept C131140672 @default.
• W2000517603 hasConcept C134935766 @default.
• W2000517603 hasConcept C143065580 @default.
• W2000517603 hasConcept C143425029 @default.
• W2000517603 hasConcept C153911025 @default.
• W2000517603 hasConcept C156719811 @default.
• W2000517603 hasConcept C16318435 @default.
• W2000517603 hasConcept C188036394 @default.
• W2000517603 hasConcept C2756471 @default.
• W2000517603 hasConcept C31254050 @default.
• W2000517603 hasConcept C34688535 @default.
• W2000517603 hasConcept C49105822 @default.
• W2000517603 hasConcept C552990157 @default.
• W2000517603 hasConcept C55493867 @default.
• W2000517603 hasConcept C64241487 @default.
• W2000517603 hasConcept C73573662 @default.
• W2000517603 hasConcept C76535049 @default.
• W2000517603 hasConcept C82381507 @default.
• W2000517603 hasConcept C86339819 @default.
• W2000517603 hasConcept C86803240 @default.

• next