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- W2000519830 abstract "Abstract A new class of methyleneamine‐linked bis‐heterocycles that exhibit antimicrobial activity was synthesized. Bromination of 1 followed by condensation with thiourea gave 3 . The reaction of 3 with propargyl bromide in dry toluene under inert atmosphere led to the formation of 4 . Its subsequent reaction with different aromatic azides 5 using CuSO 4 .5H 2 O‐sodiumascorbate system in a 2:1 mixture of water and tert‐butylalcohol yielded the title compounds 6a , 6b , 6c , 6d , 6e , 6f , 6g , 6h , 6i , 6j in good yields. The identities of these compounds were confirmed following elemental analysis, IR, 1 H, 13 C NMR, and mass spectral studies. All the title compounds exhibited pronounced in vitro antibacterial and antifungal activities. J. Heterocyclic Chem., (2011)." @default.
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- W2000519830 date "2011-06-09" @default.
- W2000519830 modified "2023-10-18" @default.
- W2000519830 title "Synthesis and antimicrobial activity of a new class of methyleneamine-linked bis-heterocycles" @default.
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- W2000519830 doi "https://doi.org/10.1002/jhet.638" @default.
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