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• W2000519887 abstract "Changes in 5-hydroxytryptamine (5-HT) efflux have been studied for the first time using differential pulse amperometry (DPA). In vitro observations show that the oxidation potential of 5-HT at 37°C is 160 mV. The amperometric signal corresponding to 5-HT was measured in the lateral hypothalamus after brief electrical stimulation of the dorsal raphe nucleus (10 s, 25 or 50 Hz, 300 μA) every 5 or 10 min. Pargyline (100 mg/kg ip) and d-norfenfluramine (5 mg/kg ip) increased the signal to 194 and 243%, respectively. Tetrodotoxin (1 μl, 100 mM), injected in the proximity of the working electrode, caused the signal to disappear. 8-OH-DPAT (250μg/kg sc) reduced it to 64% for about 1 h and this effect was completely prevented by the 5HT 1A antagonist WAY 100635 (1 mg/kg sc). l -Tryptophan (100 mg/kg ip) increased the amperometric signal to 136%. No change was detected when the 5-HT precursor was given to rats pretreated with PCPA (150 mg/kg per day p.o. for 3 days). In conclusion, DPA represents a sensitive and selective approach for studying 5-hydroxytryptaminergic function, offering a good temporal and anatomical specificity." @default.
• W2000519887 created "2016-06-24" @default.
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• W2000519887 creator A5023170742 @default.
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• W2000519887 date "1996-09-01" @default.
• W2000519887 modified "2023-09-24" @default.
• W2000519887 title "Electrically evoked 5-hydroxytryptamine efflux in rat hypothalamus studied using in vivo amperometry" @default.
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• W2000519887 doi "https://doi.org/10.1016/0165-0270(96)00075-1" @default.
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• W2000519887 hasPublicationYear "1996" @default.
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