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- W2000519902 abstract "Three potential routes to generation of reactive oxygen species (ROS) from α-tocopherolquinone (α-TQ) have been identified. The quinone of the water-soluble vitamin E analogue Trolox C (Trol-Q) is reduced by hydrated electron and isopropanol α-hydroxyalkyl radical, and the resulting semiquinone reacts with molecular oxygen to form superoxide with a second order rate constant of 1.3 × 108 dm3/mol/s, illustrating the potential for redox cycling. Illumination (UV-A, 355 nm) of the quinone of 2,2,5,7,8-pentamethyl-6-hydroxychromanol (PMHC-Q) leads to a reactive short-lived (ca. 10− 6 s) triplet state, able to oxidise tryptophan with a second order rate constant greater than 109 dm3/mol/s. The triplet states of these quinones sensitize singlet oxygen formation with quantum yields of about 0.8. Such potentially damaging reactions of α-TQ may in part account for the recent findings that high levels of dietary vitamin E supplementation lack any beneficial effect and may lead to slightly enhanced levels of overall mortality." @default.
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- W2000519902 date "2007-01-01" @default.
- W2000519902 modified "2023-09-27" @default.
- W2000519902 title "Generation of superoxide and singlet oxygen from α-tocopherolquinone and analogues" @default.
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- W2000519902 doi "https://doi.org/10.1080/10715760701324075" @default.
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