Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000520083> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2000520083 endingPage "63" @default.
- W2000520083 startingPage "57" @default.
- W2000520083 abstract "Lambert-Eaton myasthenic syndrome (LEMS) is a neurological autoimmune disease in which downregulation of voltage-gated calcium channels (VGCCs) leads to reduced acetylcholine release from motoneuron terminals. 70% of cases are paraneoplastic and rapid diagnosis of LEMS can result in early detection of the underlying tumor. Serological assays based on the capacity of autoantibodies to precipitate VGCCs labeled with radioligands provide valuable data. We have established a novel assay using the spider venom peptide 125I-omega-Phonetoxin IIA (125I-omegaPtxIIA). 125I-omegaPtxIIA labeled recombinant Cav2.1 and Cav2.2 channels and endogenous VGCCs in rat brain membranes. Autoantibodies that immunoprecipitate a 125I-omegaPtxIIA/channel complex were detected in 26/31 (84%) LEMS patients. The patients that were seropositive in the 125I-omegaPtxIIA assay corresponded precisely to the population that was positive for Cav2.1 and/or Cav2.2 antibodies detected using two different omega-conotoxins. Thus, the 125I-omegaPtxIIA assay detects a broader spectrum of autoantibody specificities than current omega-conotoxin-based assays." @default.
- W2000520083 created "2016-06-24" @default.
- W2000520083 creator A5023435459 @default.
- W2000520083 creator A5026552975 @default.
- W2000520083 creator A5064534549 @default.
- W2000520083 creator A5067246434 @default.
- W2000520083 creator A5078967543 @default.
- W2000520083 date "2006-04-01" @default.
- W2000520083 modified "2023-10-18" @default.
- W2000520083 title "Phoneutria nigriventer ω-Phonetoxin IIA: A new tool for anti-calcium channel autoantibody assays in Lambert–Eaton myasthenic syndrome" @default.
- W2000520083 cites W1511107734 @default.
- W2000520083 cites W1599859734 @default.
- W2000520083 cites W1964908419 @default.
- W2000520083 cites W1967217889 @default.
- W2000520083 cites W1972401689 @default.
- W2000520083 cites W1973409912 @default.
- W2000520083 cites W1973548741 @default.
- W2000520083 cites W1975882858 @default.
- W2000520083 cites W1979185055 @default.
- W2000520083 cites W1991529895 @default.
- W2000520083 cites W1993518080 @default.
- W2000520083 cites W2036565576 @default.
- W2000520083 cites W2037301093 @default.
- W2000520083 cites W2043271680 @default.
- W2000520083 cites W2045194229 @default.
- W2000520083 cites W2052357592 @default.
- W2000520083 cites W2054835907 @default.
- W2000520083 cites W2056535632 @default.
- W2000520083 cites W2065266717 @default.
- W2000520083 cites W2090157435 @default.
- W2000520083 cites W2112520390 @default.
- W2000520083 cites W2116053362 @default.
- W2000520083 cites W2143130157 @default.
- W2000520083 cites W2143644298 @default.
- W2000520083 cites W2146572660 @default.
- W2000520083 cites W2154166392 @default.
- W2000520083 cites W2170787296 @default.
- W2000520083 cites W2742110424 @default.
- W2000520083 cites W2912991414 @default.
- W2000520083 doi "https://doi.org/10.1016/j.nbd.2005.10.003" @default.
- W2000520083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16289869" @default.
- W2000520083 hasPublicationYear "2006" @default.
- W2000520083 type Work @default.
- W2000520083 sameAs 2000520083 @default.
- W2000520083 citedByCount "15" @default.
- W2000520083 countsByYear W20005200832012 @default.
- W2000520083 countsByYear W20005200832014 @default.
- W2000520083 countsByYear W20005200832018 @default.
- W2000520083 countsByYear W20005200832019 @default.
- W2000520083 countsByYear W20005200832020 @default.
- W2000520083 crossrefType "journal-article" @default.
- W2000520083 hasAuthorship W2000520083A5023435459 @default.
- W2000520083 hasAuthorship W2000520083A5026552975 @default.
- W2000520083 hasAuthorship W2000520083A5064534549 @default.
- W2000520083 hasAuthorship W2000520083A5067246434 @default.
- W2000520083 hasAuthorship W2000520083A5078967543 @default.
- W2000520083 hasConcept C126322002 @default.
- W2000520083 hasConcept C159654299 @default.
- W2000520083 hasConcept C163764329 @default.
- W2000520083 hasConcept C185592680 @default.
- W2000520083 hasConcept C18699975 @default.
- W2000520083 hasConcept C203014093 @default.
- W2000520083 hasConcept C2777764698 @default.
- W2000520083 hasConcept C519063684 @default.
- W2000520083 hasConcept C71924100 @default.
- W2000520083 hasConcept C85520022 @default.
- W2000520083 hasConcept C98274493 @default.
- W2000520083 hasConceptScore W2000520083C126322002 @default.
- W2000520083 hasConceptScore W2000520083C159654299 @default.
- W2000520083 hasConceptScore W2000520083C163764329 @default.
- W2000520083 hasConceptScore W2000520083C185592680 @default.
- W2000520083 hasConceptScore W2000520083C18699975 @default.
- W2000520083 hasConceptScore W2000520083C203014093 @default.
- W2000520083 hasConceptScore W2000520083C2777764698 @default.
- W2000520083 hasConceptScore W2000520083C519063684 @default.
- W2000520083 hasConceptScore W2000520083C71924100 @default.
- W2000520083 hasConceptScore W2000520083C85520022 @default.
- W2000520083 hasConceptScore W2000520083C98274493 @default.
- W2000520083 hasIssue "1" @default.
- W2000520083 hasLocation W20005200831 @default.
- W2000520083 hasLocation W20005200832 @default.
- W2000520083 hasOpenAccess W2000520083 @default.
- W2000520083 hasPrimaryLocation W20005200831 @default.
- W2000520083 hasRelatedWork W1977117749 @default.
- W2000520083 hasRelatedWork W1991529895 @default.
- W2000520083 hasRelatedWork W2000520083 @default.
- W2000520083 hasRelatedWork W2010924679 @default.
- W2000520083 hasRelatedWork W2070485761 @default.
- W2000520083 hasRelatedWork W2101875571 @default.
- W2000520083 hasRelatedWork W2143644298 @default.
- W2000520083 hasRelatedWork W2146572660 @default.
- W2000520083 hasRelatedWork W2148995152 @default.
- W2000520083 hasRelatedWork W2412719698 @default.
- W2000520083 hasVolume "22" @default.
- W2000520083 isParatext "false" @default.
- W2000520083 isRetracted "false" @default.
- W2000520083 magId "2000520083" @default.
- W2000520083 workType "article" @default.