Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000520243> ?p ?o ?g. }
- W2000520243 endingPage "1242" @default.
- W2000520243 startingPage "1238" @default.
- W2000520243 abstract "The adult dentate gyrus generates new granule cells (GCs) that develop over several weeks and integrate into the preexisting network. Although adult hippocampal neurogenesis has been implicated in learning and memory, the specific role of new GCs remains unclear. We examined whether immature adult-born neurons contribute to information encoding. By combining calcium imaging and electrophysiology in acute slices, we found that weak afferent activity recruits few mature GCs while activating a substantial proportion of the immature neurons. These different activation thresholds are dictated by an enhanced excitation/inhibition balance transiently expressed in immature GCs. Immature GCs exhibit low input specificity that switches with time toward a highly specific responsiveness. Therefore, activity patterns entering the dentate gyrus can undergo differential decoding by a heterogeneous population of GCs originated at different times." @default.
- W2000520243 created "2016-06-24" @default.
- W2000520243 creator A5018514790 @default.
- W2000520243 creator A5019837733 @default.
- W2000520243 creator A5034448567 @default.
- W2000520243 creator A5048493956 @default.
- W2000520243 date "2012-03-09" @default.
- W2000520243 modified "2023-10-06" @default.
- W2000520243 title "Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons" @default.
- W2000520243 cites W1590632482 @default.
- W2000520243 cites W1963940970 @default.
- W2000520243 cites W1980576528 @default.
- W2000520243 cites W1983226940 @default.
- W2000520243 cites W1989893274 @default.
- W2000520243 cites W1998632588 @default.
- W2000520243 cites W2001344057 @default.
- W2000520243 cites W2010053974 @default.
- W2000520243 cites W2014460069 @default.
- W2000520243 cites W2018743597 @default.
- W2000520243 cites W2022036472 @default.
- W2000520243 cites W2023147143 @default.
- W2000520243 cites W2050305231 @default.
- W2000520243 cites W2050386667 @default.
- W2000520243 cites W2051173215 @default.
- W2000520243 cites W2053326179 @default.
- W2000520243 cites W2063466545 @default.
- W2000520243 cites W2069785065 @default.
- W2000520243 cites W2074052814 @default.
- W2000520243 cites W2078003702 @default.
- W2000520243 cites W2096131563 @default.
- W2000520243 cites W2105619265 @default.
- W2000520243 cites W2111004700 @default.
- W2000520243 cites W2120485135 @default.
- W2000520243 cites W2120811265 @default.
- W2000520243 cites W2121009504 @default.
- W2000520243 cites W2124909604 @default.
- W2000520243 cites W2128725941 @default.
- W2000520243 cites W2133642086 @default.
- W2000520243 cites W2135046848 @default.
- W2000520243 cites W2140552585 @default.
- W2000520243 cites W2160071886 @default.
- W2000520243 doi "https://doi.org/10.1126/science.1214956" @default.
- W2000520243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3385415" @default.
- W2000520243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22282476" @default.
- W2000520243 hasPublicationYear "2012" @default.
- W2000520243 type Work @default.
- W2000520243 sameAs 2000520243 @default.
- W2000520243 citedByCount "332" @default.
- W2000520243 countsByYear W20005202432012 @default.
- W2000520243 countsByYear W20005202432013 @default.
- W2000520243 countsByYear W20005202432014 @default.
- W2000520243 countsByYear W20005202432015 @default.
- W2000520243 countsByYear W20005202432016 @default.
- W2000520243 countsByYear W20005202432017 @default.
- W2000520243 countsByYear W20005202432018 @default.
- W2000520243 countsByYear W20005202432019 @default.
- W2000520243 countsByYear W20005202432020 @default.
- W2000520243 countsByYear W20005202432021 @default.
- W2000520243 countsByYear W20005202432022 @default.
- W2000520243 countsByYear W20005202432023 @default.
- W2000520243 crossrefType "journal-article" @default.
- W2000520243 hasAuthorship W2000520243A5018514790 @default.
- W2000520243 hasAuthorship W2000520243A5019837733 @default.
- W2000520243 hasAuthorship W2000520243A5034448567 @default.
- W2000520243 hasAuthorship W2000520243A5048493956 @default.
- W2000520243 hasBestOaLocation W20005202432 @default.
- W2000520243 hasConcept C121332964 @default.
- W2000520243 hasConcept C169760540 @default.
- W2000520243 hasConcept C185263204 @default.
- W2000520243 hasConcept C24890656 @default.
- W2000520243 hasConcept C2776464000 @default.
- W2000520243 hasConcept C2781161787 @default.
- W2000520243 hasConcept C2781291010 @default.
- W2000520243 hasConcept C2908647359 @default.
- W2000520243 hasConcept C4746552 @default.
- W2000520243 hasConcept C71924100 @default.
- W2000520243 hasConcept C86803240 @default.
- W2000520243 hasConcept C99454951 @default.
- W2000520243 hasConceptScore W2000520243C121332964 @default.
- W2000520243 hasConceptScore W2000520243C169760540 @default.
- W2000520243 hasConceptScore W2000520243C185263204 @default.
- W2000520243 hasConceptScore W2000520243C24890656 @default.
- W2000520243 hasConceptScore W2000520243C2776464000 @default.
- W2000520243 hasConceptScore W2000520243C2781161787 @default.
- W2000520243 hasConceptScore W2000520243C2781291010 @default.
- W2000520243 hasConceptScore W2000520243C2908647359 @default.
- W2000520243 hasConceptScore W2000520243C4746552 @default.
- W2000520243 hasConceptScore W2000520243C71924100 @default.
- W2000520243 hasConceptScore W2000520243C86803240 @default.
- W2000520243 hasConceptScore W2000520243C99454951 @default.
- W2000520243 hasIssue "6073" @default.
- W2000520243 hasLocation W20005202431 @default.
- W2000520243 hasLocation W20005202432 @default.
- W2000520243 hasLocation W20005202433 @default.
- W2000520243 hasLocation W20005202434 @default.
- W2000520243 hasOpenAccess W2000520243 @default.
- W2000520243 hasPrimaryLocation W20005202431 @default.
- W2000520243 hasRelatedWork W1499468620 @default.