FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000520368> ?p ?o ?g. }

• W2000520368 endingPage "180" @default.
• W2000520368 startingPage "174" @default.
• W2000520368 abstract "Osteosarcoma is one of the most common malignant bone tumors in children and adolescents. Although extensive efforts have been made in anti-osteosarcoma therapy in recent decades, there are no effective low-toxicity drugs for treating patients with metastatic osteosarcoma. Hence, potent anti-metastatic osteosarcoma drugs are highly desired. In this study, we explored novel small molecular anti-metastatic osteosarcoma agents and found that columbamine (COL), an active component of the herb Coptis chinensis, inhibited the proliferation and neovascularization of metastatic osteosarcoma U2OS cells. COL effectively suppressed U2OS cell proliferation in vitro with an IC(50) of 21.31±0.38μM, with low cytotoxicity. Mechanistic studies revealed that COL induces cell cycle arrest at the G2/M transition, which is associated with attenuating CDK6 gene expression and diminishing STAT3 phosphorylation. COL did not significantly promote U2OS cell apoptosis at any of the dosages tested. Additionally, COL inhibited U2OS cell-mediated neovascularization, which was accompanied by the down-regulation of matrix metalloproteinase (MMP) 2 expression and reduction of cell migration, adhesion, and invasion. Taken together, our data show that COL exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity. These results warrant further investigation of COL as a potential anti-osteosarcoma and anti-cancer drug." @default.
• W2000520368 created "2016-06-24" @default.
• W2000520368 creator A5002879073 @default.
• W2000520368 creator A5007086351 @default.
• W2000520368 creator A5016683563 @default.
• W2000520368 creator A5017652215 @default.
• W2000520368 creator A5027319563 @default.
• W2000520368 creator A5046709483 @default.
• W2000520368 creator A5048333692 @default.
• W2000520368 creator A5052307657 @default.
• W2000520368 creator A5057543608 @default.
• W2000520368 creator A5070169068 @default.
• W2000520368 date "2012-12-01" @default.
• W2000520368 modified "2023-10-18" @default.
• W2000520368 title "Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity" @default.
• W2000520368 cites W107447975 @default.
• W2000520368 cites W161219549 @default.
• W2000520368 cites W1626841779 @default.
• W2000520368 cites W1970719970 @default.
• W2000520368 cites W1972614384 @default.
• W2000520368 cites W1977908579 @default.
• W2000520368 cites W1984265558 @default.
• W2000520368 cites W1986428743 @default.
• W2000520368 cites W1986768402 @default.
• W2000520368 cites W1988325237 @default.
• W2000520368 cites W1991064648 @default.
• W2000520368 cites W1992112921 @default.
• W2000520368 cites W1992642151 @default.
• W2000520368 cites W1994618743 @default.
• W2000520368 cites W1999654023 @default.
• W2000520368 cites W2003478263 @default.
• W2000520368 cites W2009705018 @default.
• W2000520368 cites W2013239147 @default.
• W2000520368 cites W2018707799 @default.
• W2000520368 cites W2021381383 @default.
• W2000520368 cites W2026314724 @default.
• W2000520368 cites W2026659768 @default.
• W2000520368 cites W2029470215 @default.
• W2000520368 cites W2033710224 @default.
• W2000520368 cites W2039190147 @default.
• W2000520368 cites W2044393321 @default.
• W2000520368 cites W2046131550 @default.
• W2000520368 cites W2051131006 @default.
• W2000520368 cites W2057704683 @default.
• W2000520368 cites W2068477388 @default.
• W2000520368 cites W2078888969 @default.
• W2000520368 cites W2086078381 @default.
• W2000520368 cites W2086977969 @default.
• W2000520368 cites W2089528756 @default.
• W2000520368 cites W2110671754 @default.
• W2000520368 cites W2112703519 @default.
• W2000520368 cites W2115972059 @default.
• W2000520368 cites W2116354931 @default.
• W2000520368 cites W2117692326 @default.
• W2000520368 cites W2134614413 @default.
• W2000520368 cites W2135314765 @default.
• W2000520368 cites W2144926865 @default.
• W2000520368 cites W2161708429 @default.
• W2000520368 cites W2169772701 @default.
• W2000520368 cites W2327261833 @default.
• W2000520368 cites W2043094195 @default.
• W2000520368 doi "https://doi.org/10.1016/j.toxlet.2012.10.015" @default.
• W2000520368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23124089" @default.
• W2000520368 hasPublicationYear "2012" @default.
• W2000520368 type Work @default.
• W2000520368 sameAs 2000520368 @default.
• W2000520368 citedByCount "45" @default.
• W2000520368 countsByYear W20005203682013 @default.
• W2000520368 countsByYear W20005203682014 @default.
• W2000520368 countsByYear W20005203682015 @default.
• W2000520368 countsByYear W20005203682016 @default.
• W2000520368 countsByYear W20005203682017 @default.
• W2000520368 countsByYear W20005203682018 @default.
• W2000520368 countsByYear W20005203682019 @default.
• W2000520368 countsByYear W20005203682020 @default.
• W2000520368 countsByYear W20005203682021 @default.
• W2000520368 countsByYear W20005203682022 @default.
• W2000520368 crossrefType "journal-article" @default.
• W2000520368 hasAuthorship W2000520368A5002879073 @default.
• W2000520368 hasAuthorship W2000520368A5007086351 @default.
• W2000520368 hasAuthorship W2000520368A5016683563 @default.
• W2000520368 hasAuthorship W2000520368A5017652215 @default.
• W2000520368 hasAuthorship W2000520368A5027319563 @default.
• W2000520368 hasAuthorship W2000520368A5046709483 @default.
• W2000520368 hasAuthorship W2000520368A5048333692 @default.
• W2000520368 hasAuthorship W2000520368A5052307657 @default.
• W2000520368 hasAuthorship W2000520368A5057543608 @default.
• W2000520368 hasAuthorship W2000520368A5070169068 @default.
• W2000520368 hasConcept C109316439 @default.
• W2000520368 hasConcept C121608353 @default.
• W2000520368 hasConcept C126322002 @default.
• W2000520368 hasConcept C190283241 @default.
• W2000520368 hasConcept C202751555 @default.
• W2000520368 hasConcept C203014093 @default.
• W2000520368 hasConcept C2777760704 @default.
• W2000520368 hasConcept C2778271429 @default.
• W2000520368 hasConcept C2780394083 @default.
• W2000520368 hasConcept C29537977 @default.

• next