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- W2000520598 abstract "Previous comparisons of gene location in the three major groups of mammals (eutherians, marsupials, and monotremes) have suggested that the long arm of the human X represents the ancestral mammalian X chromosome, whereas the short arm represents an autosomal region(s) recently added to the eutherian X chromosome. To identify the fusion point of this ancient X-autosome rearrangement, we have mapped four genes, three of which map near the centromere of the human Xp, in marsupials and in a monotreme. We found that ARAF1, ALAS2, and GATA1 are located on the X chromosome in marsupials, and ALAS2 and GATA1 are also located on the X in the platypus. This implies that the proximal short arm of the human X chromosome, including the centromere, was part of the ancestral mammalian X chromosome. The fusion point between the conserved region and the recently added regions therefore maps to human Xp11.23, although gene order on the human X indicates that there has been some rearrangement of this region." @default.
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- W2000520598 date "1996-07-01" @default.
- W2000520598 modified "2023-09-27" @default.
- W2000520598 title "Comparative Mapping Identifies the Fusion Point of an Ancient Mammalian X-Autosomal Rearrangement" @default.
- W2000520598 doi "https://doi.org/10.1006/geno.1996.0323" @default.
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