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- W2000521199 abstract "Monocyte exposure to tumor cells induces a transient state in which these cells are refractory to further exposure to cancer. This phenomenon, termed tumor tolerance, is characterized by a decreased production of proinflammatory cytokines in response to tumors. In the past, we found that this effect comprises IRAK-M up regulation and TLR4 and CD44 activation. Herein we have established a human model of tumor tolerance and have observed a marked down-regulation of MHCII molecules as well as the MHCII master regulator, CIITA, in monocytes/macrophages. These cells combine an impaired capability for antigen presentation with potent phagocytic activity and exhibit an M2-like phenotype. In addition circulating monocytes isolated from Chronic Lymphocytic Leukemia patients exhibited the same profile as tumor tolerant cells after tumor ex vivo exposition." @default.
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- W2000521199 date "2012-06-01" @default.
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- W2000521199 title "Impaired antigen presentation and potent phagocytic activity identifying tumor-tolerant human monocytes" @default.
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- W2000521199 doi "https://doi.org/10.1016/j.bbrc.2012.05.124" @default.
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