FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000521810> ?p ?o ?g. }

• W2000521810 endingPage "1005" @default.
• W2000521810 startingPage "991" @default.
• W2000521810 abstract "To study the role of kinase C phosphorylation in the distribution and function of GAP-43 we have generated a panel of mAbs that distinguish between GAP-43 that has been phosphorylated by kinase C and forms that have not. One class of antibodies, typified by 2G12/C7, reacts with only the phosphorylated form of GAP-43; it recognizes the peptide IQAS(PO4)FR equivalent to residues 38-43 that includes the single kinase C phosphorylation site at serine. Another, exemplified by 10E8/E7, reacts with both phosphorylated and nonphosphorylated forms. We have used the antibodies to study the distribution of kinase C-phosphorylated GAP-43 during axonogenesis and in the adult nervous system. Two major findings emerge. First, there is a lag between the initiation of axon outgrowth and the phosphorylation of GAP-43 by kinase C. The extent of this lag period varies between the different structures studied. In some cases, e.g., the trigeminal nerve, our result suggest that kinase C phosphorylation may be correlated with proximity of the growing axon to its target. Second, kinase C-phosphorylated GAP-43 is always spatially restricted to the distal axon. It is never seen either proximally or in cell bodies, even those with high levels of GAP-43 protein. This result also implies that GAP-43 is axonally transported in the non-kinase C phosphorylated form. Thus, kinase C phosphorylation of GAP-43 is not required for axon outgrowth or growth cone function per se and may be more related to interactions of the growth cone with its environment." @default.
• W2000521810 created "2016-06-24" @default.
• W2000521810 creator A5004424957 @default.
• W2000521810 creator A5069501233 @default.
• W2000521810 creator A5089887663 @default.
• W2000521810 date "1991-03-01" @default.
• W2000521810 modified "2023-09-26" @default.
• W2000521810 title "Monoclonal antibodies show that kinase C phosphorylation of GAP-43 during axonogenesis is both spatially and temporally restricted in vivo." @default.
• W2000521810 cites W1496172532 @default.
• W2000521810 cites W1534834744 @default.
• W2000521810 cites W1547515010 @default.
• W2000521810 cites W1565021068 @default.
• W2000521810 cites W1568075863 @default.
• W2000521810 cites W1597634219 @default.
• W2000521810 cites W1619042305 @default.
• W2000521810 cites W1697944648 @default.
• W2000521810 cites W1744219949 @default.
• W2000521810 cites W1838152396 @default.
• W2000521810 cites W1842081459 @default.
• W2000521810 cites W185547289 @default.
• W2000521810 cites W1929472049 @default.
• W2000521810 cites W1972797479 @default.
• W2000521810 cites W1975781078 @default.
• W2000521810 cites W1977209656 @default.
• W2000521810 cites W1977826228 @default.
• W2000521810 cites W1980711990 @default.
• W2000521810 cites W1991501125 @default.
• W2000521810 cites W2004917770 @default.
• W2000521810 cites W2029288564 @default.
• W2000521810 cites W2034379792 @default.
• W2000521810 cites W2050217213 @default.
• W2000521810 cites W2055254971 @default.
• W2000521810 cites W2057217877 @default.
• W2000521810 cites W2059940521 @default.
• W2000521810 cites W2062898068 @default.
• W2000521810 cites W2071996031 @default.
• W2000521810 cites W2080823223 @default.
• W2000521810 cites W2082834967 @default.
• W2000521810 cites W2086745732 @default.
• W2000521810 cites W2088002244 @default.
• W2000521810 cites W2088857229 @default.
• W2000521810 cites W2106279306 @default.
• W2000521810 cites W2123223673 @default.
• W2000521810 cites W2130174790 @default.
• W2000521810 cites W2131331811 @default.
• W2000521810 cites W2135702611 @default.
• W2000521810 cites W2145562348 @default.
• W2000521810 cites W2151678953 @default.
• W2000521810 cites W2153696262 @default.
• W2000521810 cites W2202400059 @default.
• W2000521810 cites W2251920431 @default.
• W2000521810 cites W2268944289 @default.
• W2000521810 doi "https://doi.org/10.1083/jcb.112.5.991" @default.
• W2000521810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2288878" @default.
• W2000521810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1705561" @default.
• W2000521810 hasPublicationYear "1991" @default.
• W2000521810 type Work @default.
• W2000521810 sameAs 2000521810 @default.
• W2000521810 citedByCount "172" @default.
• W2000521810 countsByYear W20005218102012 @default.
• W2000521810 countsByYear W20005218102013 @default.
• W2000521810 countsByYear W20005218102014 @default.
• W2000521810 countsByYear W20005218102017 @default.
• W2000521810 countsByYear W20005218102019 @default.
• W2000521810 countsByYear W20005218102020 @default.
• W2000521810 crossrefType "journal-article" @default.
• W2000521810 hasAuthorship W2000521810A5004424957 @default.
• W2000521810 hasAuthorship W2000521810A5069501233 @default.
• W2000521810 hasAuthorship W2000521810A5089887663 @default.
• W2000521810 hasBestOaLocation W20005218101 @default.
• W2000521810 hasConcept C11960822 @default.
• W2000521810 hasConcept C153911025 @default.
• W2000521810 hasConcept C184235292 @default.
• W2000521810 hasConcept C195794163 @default.
• W2000521810 hasConcept C203014093 @default.
• W2000521810 hasConcept C204232928 @default.
• W2000521810 hasConcept C2779530196 @default.
• W2000521810 hasConcept C55493867 @default.
• W2000521810 hasConcept C82495950 @default.
• W2000521810 hasConcept C86803240 @default.
• W2000521810 hasConcept C90770895 @default.
• W2000521810 hasConcept C95444343 @default.
• W2000521810 hasConcept C97029542 @default.
• W2000521810 hasConceptScore W2000521810C11960822 @default.
• W2000521810 hasConceptScore W2000521810C153911025 @default.
• W2000521810 hasConceptScore W2000521810C184235292 @default.
• W2000521810 hasConceptScore W2000521810C195794163 @default.
• W2000521810 hasConceptScore W2000521810C203014093 @default.
• W2000521810 hasConceptScore W2000521810C204232928 @default.
• W2000521810 hasConceptScore W2000521810C2779530196 @default.
• W2000521810 hasConceptScore W2000521810C55493867 @default.
• W2000521810 hasConceptScore W2000521810C82495950 @default.
• W2000521810 hasConceptScore W2000521810C86803240 @default.
• W2000521810 hasConceptScore W2000521810C90770895 @default.
• W2000521810 hasConceptScore W2000521810C95444343 @default.
• W2000521810 hasConceptScore W2000521810C97029542 @default.
• W2000521810 hasIssue "5" @default.
• W2000521810 hasLocation W20005218101 @default.

• next