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• W2000521900 abstract "Purpose of review The transplantation of donor hematopoietic stem cells (HSC) is an attractive strategy for inducing transplantation tolerance. The clinical application of conventional HSC transplantation (HSCT) protocols in organ transplantation, however, has so far been prevented by unacceptable toxicities. In experimental HSC-based tolerance models immunosuppressive drugs have been explored mainly for two reasons: firstly, to find a compatible regimen of conventional immunosuppressive drugs whose transient use would be required as “safety net” when tolerance strategies are first tested in the clinical setting; and secondly, to allow tolerance induction with milder conditioning regimens through the temporary administration of immunosuppression. In this review, we briefly summarize the current experience with immunosuppressive drugs in cell-based tolerance regimens. Recent findings Immunosuppressive drugs have been routinely used for a long time in clinical HSCT performed for hematological indications. Several cyclosporine (CyA)-based drug regimens have been shown to reduce the incidence and/or severity of graft-versus-host disease (GvHD). Little is known from clinical data, however, about a possible impact of these drugs on engraftment or tolerance. In experimental bone marrow transplantation (BMT) protocols involving global recipient T cell depletion, temporary treatment with cyclosporine (CyA) has been investigated and was found to be not detrimental. CyA can indeed be necessary for tolerance induction in such systems. In contrast, in some, but not all experimental models of BMT involving costimulation blockade (CB), calcineurin-inhibitors displayed a tolerance-abrogating effect. Rapamycin proved beneficial in such models, allowing mixed chimerism and tolerance to be induced with reduced recipient conditioning. Summary Distinct immunosuppressive drugs can either promote or prevent tolerance after HSC transplantation, depending on the details of the regimen. These effects should be considered when clinical translation of a particular protocol is considered." @default.
• W2000521900 created "2016-06-24" @default.
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• W2000521900 date "2004-09-01" @default.
• W2000521900 modified "2023-09-23" @default.
• W2000521900 title "Influence of immunosuppressive drugs on cell-induced graft tolerance" @default.
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• W2000521900 doi "https://doi.org/10.1097/01.mot.0000134873.10331.5c" @default.
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