FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000522159> ?p ?o ?g. }

• W2000522159 endingPage "321" @default.
• W2000522159 startingPage "313" @default.
• W2000522159 abstract "Deregulation of the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR)-70kDa ribosomal protein S6 kinase 1 (p70(S6K)) pathway is commonly observed in many tumors. This pathway controls proliferation, survival, and translation, and its overactivation is associated with poor prognosis for tumor-associated survival. Current efforts focus on the development of novel inhibitors of this pathway. In a cell-based high-throughput screening assay of 15,272 pure natural compounds, we identified pomiferin triacetate as a potent stabilizer of the tumor suppressor programmed cell death 4 (Pdcd4). Mechanistically, pomiferin triacetate appeared as a general inhibitor of the PI3K-Akt-mTOR-p70(S6K) cascade. Interference with this pathway occurred downstream of Akt but upstream of p70(S6K). Specifically, mTOR kinase emerged as the molecular target of pomiferin triacetate, with similar activities against mTOR complexes 1 and 2. In an in vitro mTOR kinase assay pomiferin triacetate dose-dependently inhibited mTOR with an IC50 of 6.2 μM. Molecular docking studies supported the interaction of the inhibitor with the catalytic site of mTOR. Importantly, pomiferin triacetate appeared to be highly selective for mTOR compared to a panel of 17 lipid and 50 protein kinases tested. As a consequence of the mTOR inhibition, pomiferin triacetate efficiently attenuated translation. In summary, pomiferin triacetate emerged as a novel and highly specific mTOR inhibitor with strong translation inhibitory effects. Thus, it might be an interesting lead structure for the development of mTOR- and translation-targeted anti-tumor therapies." @default.
• W2000522159 created "2016-06-24" @default.
• W2000522159 creator A5001748432 @default.
• W2000522159 creator A5007413056 @default.
• W2000522159 creator A5010005016 @default.
• W2000522159 creator A5017943869 @default.
• W2000522159 creator A5020455026 @default.
• W2000522159 creator A5031571077 @default.
• W2000522159 creator A5048962207 @default.
• W2000522159 creator A5056936426 @default.
• W2000522159 creator A5061765551 @default.
• W2000522159 creator A5066201997 @default.
• W2000522159 creator A5074636897 @default.
• W2000522159 creator A5086201121 @default.
• W2000522159 creator A5086646466 @default.
• W2000522159 creator A5086919800 @default.
• W2000522159 date "2014-04-01" @default.
• W2000522159 modified "2023-10-12" @default.
• W2000522159 title "Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor" @default.
• W2000522159 cites W1969971113 @default.
• W2000522159 cites W1970111367 @default.
• W2000522159 cites W1975691556 @default.
• W2000522159 cites W1980083852 @default.
• W2000522159 cites W1994987492 @default.
• W2000522159 cites W1995197723 @default.
• W2000522159 cites W2000110198 @default.
• W2000522159 cites W2002226709 @default.
• W2000522159 cites W2007110714 @default.
• W2000522159 cites W2008825756 @default.
• W2000522159 cites W2020927117 @default.
• W2000522159 cites W2029348880 @default.
• W2000522159 cites W2029560774 @default.
• W2000522159 cites W2035147500 @default.
• W2000522159 cites W2035521247 @default.
• W2000522159 cites W2036380534 @default.
• W2000522159 cites W2036851390 @default.
• W2000522159 cites W2054117275 @default.
• W2000522159 cites W2059344530 @default.
• W2000522159 cites W2064863361 @default.
• W2000522159 cites W2066939477 @default.
• W2000522159 cites W2073186837 @default.
• W2000522159 cites W2076379164 @default.
• W2000522159 cites W2077804275 @default.
• W2000522159 cites W2081659685 @default.
• W2000522159 cites W2081690486 @default.
• W2000522159 cites W2084951981 @default.
• W2000522159 cites W2091108445 @default.
• W2000522159 cites W2107242181 @default.
• W2000522159 cites W2111352469 @default.
• W2000522159 cites W2119397497 @default.
• W2000522159 cites W2121841892 @default.
• W2000522159 cites W2127063807 @default.
• W2000522159 cites W2129172946 @default.
• W2000522159 cites W2132629607 @default.
• W2000522159 cites W2139987952 @default.
• W2000522159 cites W2141748482 @default.
• W2000522159 cites W2143112776 @default.
• W2000522159 cites W2147380958 @default.
• W2000522159 cites W2151886488 @default.
• W2000522159 cites W2152289580 @default.
• W2000522159 cites W2152654745 @default.
• W2000522159 cites W2153867442 @default.
• W2000522159 cites W2158389310 @default.
• W2000522159 cites W2159312214 @default.
• W2000522159 cites W2161011316 @default.
• W2000522159 cites W2168180694 @default.
• W2000522159 cites W2318455626 @default.
• W2000522159 cites W4238567307 @default.
• W2000522159 doi "https://doi.org/10.1016/j.bcp.2014.01.034" @default.
• W2000522159 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3978168" @default.
• W2000522159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24513322" @default.
• W2000522159 hasPublicationYear "2014" @default.
• W2000522159 type Work @default.
• W2000522159 sameAs 2000522159 @default.
• W2000522159 citedByCount "12" @default.
• W2000522159 countsByYear W20005221592014 @default.
• W2000522159 countsByYear W20005221592015 @default.
• W2000522159 countsByYear W20005221592016 @default.
• W2000522159 countsByYear W20005221592018 @default.
• W2000522159 countsByYear W20005221592019 @default.
• W2000522159 countsByYear W20005221592022 @default.
• W2000522159 countsByYear W20005221592023 @default.
• W2000522159 crossrefType "journal-article" @default.
• W2000522159 hasAuthorship W2000522159A5001748432 @default.
• W2000522159 hasAuthorship W2000522159A5007413056 @default.
• W2000522159 hasAuthorship W2000522159A5010005016 @default.
• W2000522159 hasAuthorship W2000522159A5017943869 @default.
• W2000522159 hasAuthorship W2000522159A5020455026 @default.
• W2000522159 hasAuthorship W2000522159A5031571077 @default.
• W2000522159 hasAuthorship W2000522159A5048962207 @default.
• W2000522159 hasAuthorship W2000522159A5056936426 @default.
• W2000522159 hasAuthorship W2000522159A5061765551 @default.
• W2000522159 hasAuthorship W2000522159A5066201997 @default.
• W2000522159 hasAuthorship W2000522159A5074636897 @default.
• W2000522159 hasAuthorship W2000522159A5086201121 @default.
• W2000522159 hasAuthorship W2000522159A5086646466 @default.
• W2000522159 hasAuthorship W2000522159A5086919800 @default.
• W2000522159 hasBestOaLocation W20005221592 @default.

• next