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• W2000522350 abstract "Disrupted ontogeny of forebrain inhibitory interneurons leads to neurological disorders, including epilepsy. Adult mice lacking the urokinase plasminogen activator receptor (Plaur) have decreased numbers of neocortical GABAergic interneurons and spontaneous seizures, attributed to a reduction of hepatocyte growth factor/scatter factor (HGF/SF). We report that by increasing endogenous HGF/SF concentration in the postnatal Plaur null mouse brain maintains the interneuron populations in the adult, reverses the seizure behavior and stabilizes the spontaneous electroencephalogram activity. The perinatal intervention provides a pathway to reverse potential birth defects and ameliorate seizures in the adult." @default.
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• W2000522350 date "2010-01-01" @default.
• W2000522350 modified "2023-09-27" @default.
• W2000522350 title "Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility" @default.
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• W2000522350 doi "https://doi.org/10.1016/j.expneurol.2009.10.011" @default.
• W2000522350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812579" @default.
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