Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000522359> ?p ?o ?g. }
- W2000522359 endingPage "13" @default.
- W2000522359 startingPage "1" @default.
- W2000522359 abstract "The angiogenic, neovascular proliferative retinopathies, proliferative diabetic retinopathy (PDR), and age-dependent macular degeneration (AMD) complicated by choroidal neovascularization (CNV), also termed exudative or “wet” AMD, are common causes of blindness. The antidiabetic thiazolidinediones (TZDs), rosiglitazone, and troglitazone are PPAR agonists with demonstrable antiproliferative, and anti-inflammatory effects, in vivo, were shown to ameliorate PDR and CNV in rodent models, implying the potential efficacy of TZDs for treating proliferative retinopathies in humans. Activation of the angiotensin II type 1 receptor (AT1-R) propagates proinflammatory and proliferative pathogenic determinants underlying PDR and CNV. The antihypertensive dual AT1-R blocker (ARB), telmisartan, recently was shown to activate PPAR and improve glucose and lipid metabolism and to clinically improve PDR and CNV in rodent models. Therefore, the TZDs and telmisartan, clinically approved antidiabetic and antihypertensive drugs, respectively, may be efficacious for treating and attenuating PDR and CNV humans. Clinical trials are needed to test these possibilities." @default.
- W2000522359 created "2016-06-24" @default.
- W2000522359 creator A5027263382 @default.
- W2000522359 creator A5073836905 @default.
- W2000522359 date "2008-01-01" @default.
- W2000522359 modified "2023-09-27" @default.
- W2000522359 title "PPAR Agonists: Potential as Therapeutics for Neovascular Retinopathies" @default.
- W2000522359 cites W1487528435 @default.
- W2000522359 cites W1527827101 @default.
- W2000522359 cites W1538091014 @default.
- W2000522359 cites W1598648470 @default.
- W2000522359 cites W1740303948 @default.
- W2000522359 cites W1929670786 @default.
- W2000522359 cites W1967009650 @default.
- W2000522359 cites W1972136146 @default.
- W2000522359 cites W1974139741 @default.
- W2000522359 cites W1976401110 @default.
- W2000522359 cites W1976481038 @default.
- W2000522359 cites W1977666051 @default.
- W2000522359 cites W1978323413 @default.
- W2000522359 cites W1980065167 @default.
- W2000522359 cites W1980460430 @default.
- W2000522359 cites W1982525844 @default.
- W2000522359 cites W1984505599 @default.
- W2000522359 cites W1984676251 @default.
- W2000522359 cites W1986867477 @default.
- W2000522359 cites W1987321293 @default.
- W2000522359 cites W1989603944 @default.
- W2000522359 cites W1993762245 @default.
- W2000522359 cites W1995726033 @default.
- W2000522359 cites W1996952739 @default.
- W2000522359 cites W1998102786 @default.
- W2000522359 cites W2004658509 @default.
- W2000522359 cites W2004987008 @default.
- W2000522359 cites W2006340844 @default.
- W2000522359 cites W2006567606 @default.
- W2000522359 cites W2010651929 @default.
- W2000522359 cites W2010804179 @default.
- W2000522359 cites W2015783704 @default.
- W2000522359 cites W2016795705 @default.
- W2000522359 cites W2017719273 @default.
- W2000522359 cites W2020981164 @default.
- W2000522359 cites W2021343847 @default.
- W2000522359 cites W2029051408 @default.
- W2000522359 cites W2029178933 @default.
- W2000522359 cites W2029258190 @default.
- W2000522359 cites W2031283600 @default.
- W2000522359 cites W2031766286 @default.
- W2000522359 cites W2032484029 @default.
- W2000522359 cites W2032687008 @default.
- W2000522359 cites W2034530918 @default.
- W2000522359 cites W2041485080 @default.
- W2000522359 cites W2043014272 @default.
- W2000522359 cites W2044257849 @default.
- W2000522359 cites W2046519108 @default.
- W2000522359 cites W2047591801 @default.
- W2000522359 cites W2048685120 @default.
- W2000522359 cites W2048748448 @default.
- W2000522359 cites W2051055391 @default.
- W2000522359 cites W2051904771 @default.
- W2000522359 cites W2054731255 @default.
- W2000522359 cites W2056038262 @default.
- W2000522359 cites W2058422032 @default.
- W2000522359 cites W2061955205 @default.
- W2000522359 cites W2066103201 @default.
- W2000522359 cites W2068361594 @default.
- W2000522359 cites W2068719866 @default.
- W2000522359 cites W2072210889 @default.
- W2000522359 cites W2072238299 @default.
- W2000522359 cites W2075138825 @default.
- W2000522359 cites W2077012773 @default.
- W2000522359 cites W2078835518 @default.
- W2000522359 cites W2079551944 @default.
- W2000522359 cites W2085174145 @default.
- W2000522359 cites W2086376157 @default.
- W2000522359 cites W2089235913 @default.
- W2000522359 cites W2089422003 @default.
- W2000522359 cites W2095466964 @default.
- W2000522359 cites W2103633745 @default.
- W2000522359 cites W2104224178 @default.
- W2000522359 cites W2105064556 @default.
- W2000522359 cites W2105407506 @default.
- W2000522359 cites W2105719905 @default.
- W2000522359 cites W2107752044 @default.
- W2000522359 cites W2113328569 @default.
- W2000522359 cites W2118551928 @default.
- W2000522359 cites W2118820170 @default.
- W2000522359 cites W2120723151 @default.
- W2000522359 cites W2124100109 @default.
- W2000522359 cites W2124521298 @default.
- W2000522359 cites W2127125241 @default.
- W2000522359 cites W2129697991 @default.
- W2000522359 cites W2133861409 @default.
- W2000522359 cites W2135178747 @default.
- W2000522359 cites W2136466565 @default.
- W2000522359 cites W2137480747 @default.
- W2000522359 cites W2144829897 @default.
- W2000522359 cites W2149287982 @default.