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- W2000522513 abstract "Abstract Background Clinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF. Findings We evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. For this, the PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients. Conclusions In our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes." @default.
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- W2000522513 date "2012-10-10" @default.
- W2000522513 modified "2023-10-10" @default.
- W2000522513 title "Association between the IVS4G > T mutation in the TCF7L2 gene and susceptibility to diabetes in cystic fibrosis patients" @default.
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- W2000522513 doi "https://doi.org/10.1186/1756-0500-5-561" @default.
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